Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mitsuo Hayashida"'
Autor:
Kiyoshi Centr Res Inst Kaken Pharm Inoguchi, Tadashi Okuno, Satoru Ikegami, Gilda H. Loew, Jun Nakano, Akihiko Okuyama, Mitsuo Hayashida, Osafumi Shimada, Ping Huang, Nobuo Ishiyama, Hidenori Funamizu, Mitsuo Mimura
Publikováno v:
Journal of Medicinal Chemistry. 44:4082-4091
In the joint experimental and computational efforts reported here to obtain novel chemical entities as growth hormone secretagogues (GHSs), a small database of peptides and non-peptides known to have GHS activity was used to generate and assess a 3D
Publikováno v:
ChemInform. 22
Autor:
Mitsuo Mimura, Mitsuo Hayashida, Yoshiyuki Hiyama, Yoshitaka Ohishi, M. Tamura, Y. Iida, S. Ikegami, K. Nomiyama
Publikováno v:
ChemInform. 25
Publikováno v:
Bulletin of the Chemical Society of Japan. 63:1546-1548
A 2′,6′-diamino-1,6-anhydro disaccharide derivative (6) was prepared from maltose. The 3′,4′-diol system of 6 was successfully converted into the 3′-ene system by application of the Corey–Winter procedure, giving the hex-3′-enopyranose
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:1066-1068
Three acidic metabolites (5-7) of 6, 11-dihydro-11-(3-dimethylaminopropylidene)dibenzo[b, e]thiepin(dothiepin) were prepared. In the synthetic course, a reaction of 6, 11-dihydro-11-vinyldibenzo[b, e]thiepin-11-ol (2) with SOCl2 stereoselectively aff
Autor:
Satoru Ikegami, Yoshitaka Ohishi, Yoshiyuki Hiyama, Mitsuo Mimura, Kiyoshi Nomiyama, Mitsuo Hayashida, Makoto Tamura, Yasuhito Iida
Publikováno v:
Chemicalpharmaceutical bulletin. 41(11)
Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4-alkylidene-, 4,4-dialkyl-, or 4-
Publikováno v:
ChemInform. 21
Three acidic metabolites (5-7) of 6, 11-dihydro-11-(3-dimethylaminopropylidene)dibenzo[b, e]thiepin(dothiepin) were prepared. In the synthetic course, a reaction of 6, 11-dihydro-11-vinyldibenzo[b, e]thiepin-11-ol (2) with SOCl2 stereoselectively aff
Publikováno v:
ChemInform. 21
A 2′,6′-diamino-1,6-anhydro disaccharide derivative (6) was prepared from maltose. The 3′,4′-diol system of 6 was successfully converted into the 3′-ene system by application of the Corey–Winter procedure, giving the hex-3′-enopyranose
Publikováno v:
ChemInform. 21
New antimicrobial aminoglycosides having a pseudodisaccharide structure, 1L-(1,6/2,3)-3-amino-2-(2,6-diamino-2,6-dideoxy-α-D-allopyranosyloxy)-6-[glycyl(methyl)amino]cyclohexanol (4) and its 3′-deoxy analogue (5) have been synthesized from 1,6-anh
Autor:
Yasuo Yoneda, Mitsuo Hayashida, Shinji Tauchi, Akinori Aoyama, Tadashi Okuno, Nobuo Ishiyama, Kiyoshi Inoguchi, Mitsuo Mimura, Kiyoharu Ukai, Hirohide Ishige, Takeshi Kiyofuji
Publikováno v:
HETEROCYCLES. 67:561
The discovery and the SAR of acylproline derivatives as highly potent growth hormone secretagogues (GHSs) with good oral bioavailability are described. One representative compound, N-[3-(2,2-dimethylpropylamino)-2-hydroxypropyl]-2(R)-[l-(2,2-dimethyl