Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Mitsuo, Umetsu"'
Combinatorial optimization of the hybrid cellulase complex structure designed from modular libraries
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cellulase selectively recognizes cellulose surfaces and cleaves their β-1,4-glycosidic bonds. Combining hydrolysis using cellulase and fermentation can produce alternative fuels and chemical products. However, anaerobic bacteria produce onl
Externí odkaz:
https://doaj.org/article/b0fa33bd64b140f38c2b3bf6f7af88c5
Autor:
Andrejs Tučs, Tomoyuki Ito, Yoichi Kurumida, Sakiya Kawada, Hikaru Nakazawa, Yutaka Saito, Mitsuo Umetsu, Koji Tsuda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract In designing functional biological sequences with machine learning, the activity predictor tends to be inaccurate due to shortage of data. Top ranked sequences are thus unlikely to contain effective ones. This paper proposes to take predicti
Externí odkaz:
https://doaj.org/article/0d7e74484286481ca47596de9fb39a2c
Autor:
Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTDespite the advances in surface-display systems for directed evolution, variants with high affinity are not always enriched due to undesirable biases that increase target-unrelated variants during biopanning. Here, our goal was to design a li
Externí odkaz:
https://doaj.org/article/006271d38f2946dbaf222d586d863779
Autor:
Yoichiro Ito, Misa Ishigami, Goro Terai, Yasuyuki Nakamura, Noriko Hashiba, Teruyuki Nishi, Hikaru Nakazawa, Tomohisa Hasunuma, Kiyoshi Asai, Mitsuo Umetsu, Jun Ishii, Akihiko Kondo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A high-throughput workflow involving a streamlined genome-wide screen improves protein production in the non-conventional yeast, Komagataella phaffii, following adaptive laboratory evolution.
Externí odkaz:
https://doaj.org/article/f8d6b4a76d204cf09f7a566450ea6f5c
Autor:
Wijak Yospanya, Akari Matsumura, Yukihiro Imasato, Tomoyuki Itou, Yusuke Aoki, Hikaru Nakazawa, Takashi Matsui, Takeshi Yokoyama, Mihoko Ui, Mitsuo Umetsu, Satoru Nagatoishi, Kouhei Tsumoto, Yoshikazu Tanaka, Kazushi Kinbara
Publikováno v:
Bulletin of the Chemical Society of Japan; Sep2024, Vol. 97 Issue 9, p1-8, 8p
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract A fusion protein comprising an antibody and a cationic peptide, such as arginine-9 (R9), is a candidate molecule for efficient and cell-specific delivery of siRNA into cells in order to reduce the side effects of nucleic acid drugs. However,
Externí odkaz:
https://doaj.org/article/a93f63012e644dfbadfe780137a79059
Autor:
Shin Irumagawa, Kaito Kobayashi, Yutaka Saito, Takeshi Miyata, Mitsuo Umetsu, Tomoshi Kameda, Ryoichi Arai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle d
Externí odkaz:
https://doaj.org/article/c7e9e6f72c2f486ea2f007ade93eb967
Autor:
Tadafumi Adschiri, Seiichi Takami, Mitsuo Umetsu, Satoshi Ohara, Takashi Naka, Kimitaka Minami, Daisuke Hojo, Takanari Togashi, Toshihiko Arita, Minori Taguchi, Masahiro Itoh, Nobuaki Aoki, Gimyeong Seong, Takaaki Tomai, Akira Yoko
Publikováno v:
Bulletin of the Chemical Society of Japan. 96:133-147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4264079972fd4ed9bd3014dc77434bd4
https://doi.org/10.1246/bcsj.20220295
https://doi.org/10.1246/bcsj.20220295
Autor:
Aruto Sugiyama, Mitsuo Umetsu, Hikaru Nakazawa, Teppei Niide, Tomoko Onodera, Katsuhiro Hosokawa, Shuhei Hattori, Ryutaro Asano, Izumi Kumagai
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Small bispecific antibodies that induce T-cell–mediated cytotoxicity have the potential to damage late-stage tumor masses to a clinically relevant degree, but their cytotoxicity is critically dependent on their structural and functional pr
Externí odkaz:
https://doaj.org/article/f18cb9ec074743a0b52efdd168550715
Autor:
Yutaka Tamaru, Shuji Nakanishi, Kenya Tanaka, Mitsuo Umetsu, Hikaru Nakazawa, Aruto Sugiyama, Tomoyuki Ito, Naofumi Shimokawa, Masahiro Takagi
Publikováno v:
Journal of Bioscience and Bioengineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df1d375139d52a0961cb923329d89be
https://doi.org/10.1016/j.jbiosc.2023.03.012
https://doi.org/10.1016/j.jbiosc.2023.03.012