Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Mitsunori, Shiroishi"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract G protein-coupled receptors (GPCRs) are the largest protein family in humans and are important drug targets. Yeast, especially Saccharomyces cerevisiae, is a useful host for modifying the function and stability of GPCRs through protein engin
Externí odkaz:
https://doaj.org/article/45a1fac820274c608755b4ba00f081e6
Autor:
Fuhito Nakagawa, Marin Kikkawa, Sisi Chen, Yasuomi Miyashita, Norie Hamaguchi-Suzuki, Minami Shibuya, Soichi Yamashita, Lisa Nagase, Satoshi Yasuda, Mitsunori Shiroishi, Toshiya Senda, Keisuke Ito, Takeshi Murata, Satoshi Ogasawara
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid environment and better thermostabil
Externí odkaz:
https://doaj.org/article/311e47254bf243f790c71dd2fbab2556
Autor:
Chinatsu Shinozaki, Keita Kohno, Mitsunori Shiroishi, Daisuke Takahashi, Yu Yoshikawa, Yoshito Abe, Kenji Hamase, Makoto Nakakido, Kohei Tsumoto, Kazuhide Inoue, Makoto Tsuda, Tadashi Ueda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract We have recently developed a mouse monoclonal antibody (12–10H) binding to the head domain region in rat P2X4 receptor (rP2X4R, which is crucial for the pathogenesis of neuropathic pain) expressed on the cell with the highest binding affin
Externí odkaz:
https://doaj.org/article/56486021f0394e62b51df59f5de03618
Autor:
Mafuka Suzuki, Haruka Fujimori, Kakeru Wakatsuki, Yuya Manaka, Haruka Asai, Mai Hyodo, Yusuke Matsuno, Rika Kusumoto-Matsuo, Mitsunori Shiroishi, Ken-Ichi Yoshioka
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0281168 (2023)
Malignancy is often associated with therapeutic resistance and metastasis, usually arising after therapeutic treatment. These include radio- and chemo-therapies, which cause cancer cell death by inducing DNA double strand breaks (DSBs). However, it i
Externí odkaz:
https://doaj.org/article/898c10725f214838b8865f9b3e7738d3
Autor:
Satoshi Ogasawara, Fuhito Nakagawa, Marin Kikkawa, Sisi Chen, Yasuomi Miyashita, Norie Hamaguchi-Suzuki, Minami Shibuya, Soichi Yamashita, Lisa Nagase, Satoshi Yasuda, Mitsunori Shiroishi, Toshiya Senda, Keisuke Ito, Takeshi Murata
Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid environment and better thermostability in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61f4e5aaff28a99997cc0c52c5ab60b5
https://doi.org/10.21203/rs.3.rs-2599981/v1
https://doi.org/10.21203/rs.3.rs-2599981/v1
Autor:
Taisei Yamamoto, Satoshi Yasuda, Rinshi S. Kasai, Ryosuke Nakano, Simon Hikiri, Kanna Sugaya, Tomohiko Hayashi, Satoshi Ogasawara, Mitsunori Shiroishi, Takahiro K. Fujiwara, Masahiro Kinoshita, Takeshi Murata
Publikováno v:
Protein Science. 31
We challenged the stabilization of a G-protein coupled receptor (GPCR) in the active state solely by multiple amino-acid mutations without the agonist binding. For many GPCRs, the free energy of the active state is higher than that of the inactive st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396168dd3f65bdf173a92cb29e0c8114
https://doi.org/10.1002/pro.4425
https://doi.org/10.1002/pro.4425
Publikováno v:
Biochemical and Biophysical Research Communications. 533:1413-1418
V-ATPases are ubiquitous proton-transporting ATPases of eukaryotic and prokaryotic membranes that utilize energy from ATP hydrolysis. The hydrophilic catalytic part called V1-ATPase is composed of a ring-shaped hexametric A3B3 complex and a central D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec2e5318eb5b01cd37883294412609b4
https://doi.org/10.1016/j.bbrc.2020.10.033
https://doi.org/10.1016/j.bbrc.2020.10.033
Autor:
Haruki Matsubara, Hideo Fukuhara, Yuko Fukunaga, Yuji Sugita, Mitsunori Shiroishi, Katsumi Maenaka, R. Kanda, Atsushi Fukunaga, Joan S. Hunt, Toyoyuki Ose, Shunsuke Kita, Naoyuki Miyashita, Kaoru Hirose, Jun Kamishikiryo, Kimiko Kuroki
Publikováno v:
The Journal of Immunology. 203:3386-3394
Human leukocyte Ig-like receptors (LILR) LILRB1 and LILRB2 are immune checkpoint receptors that regulate a wide range of physiological responses by binding to diverse ligands, including HLA-G. HLA-G is exclusively expressed in the placenta, some immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb83395f860cddd3aa6604ec9e8eb99e
https://doi.org/10.4049/jimmunol.1900562
https://doi.org/10.4049/jimmunol.1900562
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867:367-375
When the replisome collapses at a DNA damage site, a sequence-independent replication restart system is required. In Escherichia coli, PriA, PriB, and DnaT assemble in an orderly fashion at the stalled replication fork and achieve the reloading of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82888b34216e5e23091fffd395271a5
https://doi.org/10.1016/j.bbapap.2019.01.008
https://doi.org/10.1016/j.bbapap.2019.01.008
Autor:
Hidetoshi Tozaki-Saitoh, Tomohiro Yamashita, Saki Nagai, Chinatsu Shinozaki, Shuhei Kishikawa, Tadashi Ueda, Mitsunori Shiroishi, Hiroyuki Tanaka, Makoto Tsuda, Tatsuhiro Igawa, Kazuhide Inoue, Yoshito Abe
Publikováno v:
Purinergic Signalling. 15:27-35
P2X purinergic receptors are ATP-driven ionic channels expressed as trimers and showing various functions. A subtype, the P2X4 receptor present on microglial cells is highly involved in neuropathic pain. In this study, in order to prepare antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d92e8d5cf3b32160e058de89e67e26e
https://doi.org/10.1007/s11302-019-09646-5
https://doi.org/10.1007/s11302-019-09646-5