Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mitsunobu Hara"'
Publikováno v:
Biochemical and Biophysical Research Communications. 377:1085-1090
Bcl-2 is an intracellular membrane protein that prevents cells from undergoing apoptosis in response to various cell-death signals. It negatively regulates mitochondrial outer membrane permeabilization, which is responsible for the release of apoptog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3104e33da1d665520883970403c55b4
https://doi.org/10.1016/j.bbrc.2008.10.112
https://doi.org/10.1016/j.bbrc.2008.10.112
Autor:
Yutaka Kanda, Takayuki Nakashima, Masami Kaneko, Mitsunobu Hara, Yuko Uosaki, Shun-Ichi Ikeda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:887-890
Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84d9e3a9afe6a16b53dba10e6eeb3da
https://doi.org/10.1016/s0960-894x(01)00094-4
https://doi.org/10.1016/s0960-894x(01)00094-4
Publikováno v:
The Journal of Antibiotics. 48:768-772
In the course of screening for microbial products with antitumor activity, new antitumor agents, clecarmycins, were isolated from culture broth of Streptomyces sp. DO-114. The antibiotics were produced in a fermentation medium supplemented with a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603753d779286296e406c17c41dd5b96
https://doi.org/10.7164/antibiotics.48.768
https://doi.org/10.7164/antibiotics.48.768
Autor:
Kristian Pfaller, David Bernhard, Monika Senfter, Gabriele Anether, Richard Greil, Inge Tinhofer, Mitsunobu Hara
Publikováno v:
The FASEB Journal. 16:1295-1297
SPECIFIC AIMSCytotoxic agents frequently fail to induce apoptosis in neoplasias because tumor cells express increased levels of anti-apoptotic proteins, have down-regulated important executor molec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161fe0e2400d02c1dbd11ca64367abaa
https://doi.org/10.1096/fj.02-0020fje
https://doi.org/10.1096/fj.02-0020fje
Autor:
Masami Okabe, Mitsunobu Hara, Shiro Akinaga, Douglas Wood, Misook Uh, Ruben Gomez, Fuyuhiko Tamanoi, Kazuhito Akasaka, Hirofumi Nakano
Publikováno v:
Proceedings of the National Academy of Sciences. 90:2281-2285
A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of Streptomyces was found to produce active compounds named UCF1-A, UCF1-B, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5fc358bedb3d0acbaf5701bad14622
https://doi.org/10.1073/pnas.90.6.2281
https://doi.org/10.1073/pnas.90.6.2281
Autor:
Mitsunobu Hara, Yutaka Kanda, Shun-Ichi Ikeda, Yuko Uosaki, Takayuki Nakashima, Masami Kaneko
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc1bae3fcf40b8215b6bcdd62ced8b4
https://doi.org/10.1002/chin.200148217
https://doi.org/10.1002/chin.200148217
Publikováno v:
The Journal of Antibiotics. 44:33-39
In screening actinomycetes for antitumor compounds, Streptomyces sp. DO-116 was found to produce a new antitumor antibiotic sapurimycin. It is structurally related to, but distinct from, kapurimycins. The antibiotic was produced in a fermentation med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11ad2b2eb0975a0bd2084b197f8a981
https://doi.org/10.7164/antibiotics.44.33
https://doi.org/10.7164/antibiotics.44.33
Covalent modification and single-strand scission of DNA by a new antitumor antibiotic kapurimycin A3
Publikováno v:
Biochemistry. 29:10449-10455
Kapurimycin A3 is a new antitumor antibiotic isolated from a Streptomyces. It contains the anthrapyrone skeleton and a beta,gamma-unsaturated delta-keto carboxylic acid moiety in the structure. In vitro, kapurimycin causes single-strand cleavage of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9c92d1a35168158d09b6f1890b80d1
https://doi.org/10.1021/bi00498a003
https://doi.org/10.1021/bi00498a003
Publikováno v:
The Journal of Antibiotics. 43:1519-1523
The kapurimycins A1, A2 and A3 were revealed to be new antitumor antibiotics with molecular formula of C27H26O9, C26H24O9 and C27H24O9, respectively. The structures of the kapurimycins were determined by NMR spectroscopic analysis. The kapurimycins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edc4419d960423d97cfa8b01fa0b91c
https://doi.org/10.7164/antibiotics.43.1519
https://doi.org/10.7164/antibiotics.43.1519