Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mitsukane Yoshinaga"'
Autor:
Ippei Yoshida, Yusuke Honma, Mitsukane Yoshinaga, Shoko Inatani, Hiroyuki Sugiyama, Kaho Arikawa
Publikováno v:
Antimicrob Agents Chemother
Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in early childhood. However, no vaccines have yet been approved for prevention of RSV infection, and the treatment options are limited. Therefore, developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36eb35c40f1a2d73687073cdba9aad2d
https://doi.org/10.1128/aac.01407-20
https://doi.org/10.1128/aac.01407-20
Autor:
Satoshi Ozaki, Norikazu Ohtake, Makoto Higuchi, Masayuki Hanyu, Yuji Nagai, Tetsuya Suhara, Ming-Rong Zhang, Kazumi Koga, Shigeyuki Chaki, Mitsukane Yoshinaga
Publikováno v:
Journal of Nuclear Medicine. 58:1652-1658
Vasopressin 1B receptors (V1BRs) are abundantly expressed in the pituitary, and in vivo PET of V1BRs was recently enabled by our development of a specific radioligand, 11C-TASP0434299, derivatized from pyridopyrimidin-4-one. Here, we identified a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4cb500f0fa672f27dad8d9b891ae67
https://doi.org/10.2967/jnumed.116.188698
https://doi.org/10.2967/jnumed.116.188698
Autor:
Kazumi Koga, Ming-Rong Zhang, Norikazu Ohtake, Yuji Nagai, Takafumi Minamimoto, Masayuki Fujinaga, Makoto Higuchi, Yoshikatsu Uematsu, Yoko Shimoda, Tetsuya Suhara, Mitsukane Yoshinaga, Naoki Miyakoshi, Shigeyuki Chaki
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357(3):495-508
A novel pyridopyrimidin-4-one derivative, N-tert-butyl-2-[2-(3-methoxyphenyl)-6-[3-(morpholin-4-yl)propoxy]-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl]acetamide (TASP0434299), was characterized as a radioligand candidate for arginine vasopressin 1B (V1B) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e9534c60682c0ee5cfb7b6bff0f83
https://repo.qst.go.jp/records/47753
https://repo.qst.go.jp/records/47753
Autor:
Risa Kurimoto-Tsuruta, Seiken Tokura, Kosuke Kanuma, Yuya Ogata, Tamaoki Tomokazu, Hiroyuki Sugiyama, Takanori Kawaguchi, Kaho Arikawa, Takeuchi Tomoki, Nozomi Tanaka-Yamamoto, Toru Yamaguchi-Sasaki, Atsushi Okada, Ippei Yoshida, Tomoko Abe-Kumasaka, Yutaka Sugaya, Ryo Takahashi, Mitsukane Yoshinaga
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115818
The development of effective respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors against both wild-type and the D486N-mutant F protein is urgently required. We recently reported a 15-membered macrocyclic pyrazolo[1,5-a]pyrimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0be8dcf9dd71a57ac79ad406331fb1
https://doi.org/10.1016/j.bmc.2020.115818
https://doi.org/10.1016/j.bmc.2020.115818
Autor:
Kazumi, Koga, Yuji, Nagai, Masayuki, Hanyu, Mitsukane, Yoshinaga, Shigeyuki, Chaki, Norikazu, Ohtake, Satoshi, Ozaki, Ming-Rong, Zhang, Tetsuya, Suhara, Makoto, Higuchi
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 58(10)
Vasopressin 1B receptors (V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79917fa0465aed2150be24fc6a437a66
https://pubmed.ncbi.nlm.nih.gov/28450560
https://pubmed.ncbi.nlm.nih.gov/28450560
Autor:
Shuji Saito, Yoshihisa Toda, Tomoko Ishizaka, Tomomi Yamaguchi, Hiroshi Ohta, Izumi Iida, Mitsukane Yoshinaga, Nobuko Futaki, Makoto Tatsuzuki, Yasumitsu Tomishima
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:1111-1124
In this study, a novel series of CB(2) receptor agonist imine derivatives, 1-6, was synthesized and evaluated for activity against the CB(2) receptor. In a previous paper we reported the synthesis and SARs of thiazole derivative 1, a potent CB(2) rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75926154bea7bdeb73e238d83f1de22
https://doi.org/10.1016/j.bmc.2007.10.087
https://doi.org/10.1016/j.bmc.2007.10.087
Autor:
Izumi Iida, Mitsukane Yoshinaga, Makoto Tatsuzuki, Yoshihisa Toda, Shuji Saito, Yasumitsu Tomishima, Tomoko Ishizaka, Hiroshi Ohta
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2a309f2d3d5795153a08f9dbd5e4e81
https://doi.org/10.1002/chin.200809230
https://doi.org/10.1002/chin.200809230
Autor:
Makoto Tatsuzuki, Mitsukane Yoshinaga, Shuji Saito, Tomoko Ishizaka, Hiroshi Ohta, Yasumitsu Tomishima, Yoshihisa Toda, Izumi Iida
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
A novel series of N -alkylidenearylcarboxamides 4 , a CB 2 receptor agonist, were synthesized and evaluated for activity against the human CB 2 receptor. In a previous paper, we reported that sulfonamide derivative 1 acted as a potent CB 2 receptor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f058b80b98e0db106029576242ed2615
https://pubmed.ncbi.nlm.nih.gov/17884496
https://pubmed.ncbi.nlm.nih.gov/17884496
Autor:
Yoshihisa Toda, Tomoko Ishizaka, Hiroshi Ohta, Aki Morita, Shuji Saito, Mitsukane Yoshinaga, Yasumitsu Tomishima
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(18)
A novel series of sulfonamide derivatives 3, the CB(2) receptor agonists, was synthesized and evaluated for activity against the human CB(2) receptor. We first identified sulfonamide 3a, which was obtained by random screening of our in-house chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9c125bff4cb5e8257de4ab465714f5
https://pubmed.ncbi.nlm.nih.gov/17643986
https://pubmed.ncbi.nlm.nih.gov/17643986
Autor:
Kazumi Koga, Yuji Nagai, Masayuki Hanyu, Mitsukane Yoshinaga, Shigeyuki Chaki, Norikazu Ohtake, Satoshi Ozaki, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
Publikováno v:
Journal of Nuclear Medicine; Oct2017, Vol. 58 Issue 10, p1652-1658, 7p, 2 Diagrams, 1 Chart, 2 Graphs