Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Mitsuhisa Koga"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101688- (2024)
Nalmefene, an antagonist of mu- and delta-opioid receptors and a partial agonist of kappa-opioid receptors, has shown promise in reducing alcohol consumption among patients with alcohol dependence. Opioid receptors play pivotal roles in various physi
Externí odkaz:
https://doaj.org/article/a8c287eb789b4a3a827c4054fb21d38b
Autor:
Shotaro Goto, Shuichi Setoguchi, Daisuke Watase, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Koichi Matsuo, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Epidermal growth factor receptor (EGFR) inhibitors frequently cause severe skin rash as a side effect, which is a critical burden for patients who continuously receive drug treatments. Several recent clinical trials have shown that vitamin K
Externí odkaz:
https://doaj.org/article/8e5a8ad35f7e4f73afa7a366fb7ff542
Autor:
Erina Toki, Shotaro Goto, Shuichi Setoguchi, Kazuki Terada, Daisuke Watase, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Kaori Kubota, Katsunori Iwasaki, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Mitochondria generate energy through the action of the electron transport chain (ETC) and ATP synthase. Mitochondrial malfunction can lead to various disorders, including neurodegenerative diseases. Several reports have shown that menaquinon
Externí odkaz:
https://doaj.org/article/1c24714cc6734033aef9346130aa3dd7
Autor:
Kentaro Aono, Junichi Matsumoto, Taichi Matsumoto, Mitsuhisa Koga, Keisuke Migita, Koji Tominaga, Shinsuke Nakagawa, Atsushi Yamauchi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 34, Iss , Pp 101489- (2023)
Chronic obstructive pulmonary disease is an inflammatory lung disease characterized by chronic bronchitis and emphysema. Our previous study revealed that testosterone depletion induced T cell infiltration in the lungs and aggravated pulmonary emphyse
Externí odkaz:
https://doaj.org/article/fc9073871c5a43ccbf581f85257404ab
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 2, Pp 106-111 (2020)
Varenicline is a widely used and effective drug for smoking cessation. We have previously reported experimental evidence suggesting that varenicline increases the risk of cardiovascular events. Varenicline progresses atherosclerotic plaque formation
Externí odkaz:
https://doaj.org/article/dcae1777138b4a9088e331dfc15c6670
Autor:
Mitsuhisa Koga, Yuki Kanaoka, Mana Okamoto, Yuki Nakao, Koshun Inada, Saki Takayama, Yasufumi Kataoka, Atsushi Yamauchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 1, Pp 9-15 (2020)
Varenicline is a widely used and effective drug for smoking cessation. We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice. However, it remains unknown whether varenicline affects cardiovascu
Externí odkaz:
https://doaj.org/article/574af421e9b04c769b6a5d3ce81700d3
Autor:
Daisuke Watase, Shuichi Setoguchi, Nami Nagata-Akaho, Shotaro Goto, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata
Publikováno v:
Molecules, Vol 27, Iss 9, p 2727 (2022)
The intestinal absorption of hydrophobic compounds is severely influenced by their transportation rate through the unstirred water layer in the intestinal lumen. A member of the vitamin E family, α-Tocotrienol (α-T3) has remarkable pharmacological
Externí odkaz:
https://doaj.org/article/39c12113ddab477dad8cebd2517471c0
Autor:
Mitsuhisa Koga, Yuki Kanaoka, Tetsushi Tashiro, Nagisa Hashidume, Yasufumi Kataoka, Atsushi Yamauchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 224-229 (2018)
Smoking cessation is the most effective treatment in patients with emphysema and lung inflammation. The aim of the present study was to examine the effect of varenicline, a smoking cessation drug, on emphysema in porcine pancreatic elastase (PPE)-inh
Externí odkaz:
https://doaj.org/article/07a43ac193a142d092175f314c3f5544
Autor:
Hirofumi Yamakawa, Shuichi Setoguchi, Shotaro Goto, Daisuke Watase, Kazuki Terada, Nami Nagata-Akaho, Erina Toki, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 758 (2021)
The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus, an effective and safe agent for ATRA-resistant APL is needed. Menaquinone-4 (MK-4, vitamin
Externí odkaz:
https://doaj.org/article/f7dfada8c5ab4d1792ff24bb0e763734
Autor:
Kazuki Terada, Ayumi Murata, Erina Toki, Shotaro Goto, Hirofumi Yamakawa, Shuichi Setoguchi, Daisuke Watase, Mitsuhisa Koga, Jiro Takata, Kazuhisa Matsunaga, Yoshiharu Karube
Publikováno v:
Molecules, Vol 25, Iss 18, p 4206 (2020)
Schizophrenia is a severe, chronic mental illness characterized by delusions, hallucinations, negative symptoms, and cognitive dysfunction. Recently, several studies have demonstrated that the pathogenesis of schizophrenia involves mitochondrial dysf
Externí odkaz:
https://doaj.org/article/25bdee10529b436e9b26af85935fed2a