Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Mitsuhiro Yoshioka"'
Autor:
Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kaneko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pat
Externí odkaz:
https://doaj.org/article/71c32d54f9e1485594bbb40a22f388b8
Autor:
Hitomi Sasamori, Toshiaki Asakura, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Masaaki Sato, Takayuki Yoshida, Miwako Yamasaki, Akira Terao, Masahiko Watanabe, Yu Ohmura, Mitsuhiro Yoshioka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Major psychiatric disorders such as attention-deficit/hyperactivity disorder and schizophrenia are often accompanied by elevated impulsivity. However, anti-impulsive drug treatments are still limited. To explore a novel molecular target, we
Externí odkaz:
https://doaj.org/article/f24ec5e684894034a351aaa7b508ad12
Autor:
Youcef Bouchekioua, Mao Nebuka, Hitomi Sasamori, Naoya Nishitani, Chiaki Sugiura, Masaaki Sato, Mitsuhiro Yoshioka, Yu Ohmura
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Previous findings have proposed that drugs targeting 5-HT2C receptors could be promising candidates in the treatment of trauma- and stress-related disorders. However, the reduction of conditioned freezing observed in 5-HT2C receptor knock-ou
Externí odkaz:
https://doaj.org/article/f7270945ef1a4166988588ef57f9eba3
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 3, Pp 127-130 (2019)
High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in r
Externí odkaz:
https://doaj.org/article/764c0458b2824d51b80e09566678717b
Autor:
Haruko Kumamoto, Taku Yamaguchi, Kohtarou Konno, Takeshi Izumi, Takayuki Yoshida, Yu Ohmura, Masahiko Watanabe, Mitsuhiro Yoshioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 1, Pp 1-8 (2018)
Childhood maltreatment is associated with impaired adult brain function, particularly in the hippocampus, and is not only a major risk factor for some psychiatric diseases but also affects early social development and social adaptation in later life.
Externí odkaz:
https://doaj.org/article/ee3c2bcc39ff47008ff18334ed401743
Publikováno v:
Journal of Pharmacological Sciences, Vol 134, Iss 3, Pp 181-189 (2017)
Serotonin/noradrenaline reuptake inhibitors (SNRIs) are widely used for the treatment for major depressive disorder, but these drugs induce several side effects including increased aggression and impulsivity, which are risk factors for substance abus
Externí odkaz:
https://doaj.org/article/4bffb2ae6ecc49f8b5ccafe6b243f8fa
Autor:
Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
Publikováno v:
Data in Brief, Vol 11, Iss C, Pp 507-509 (2017)
The data shows attentional function, impulsivity, motivation, motor function, and motor activity in rats treated with varenicline, a stop-smoking aid. The data also shows these parameters in rats treated with varenicline after acute/chronic nicotine
Externí odkaz:
https://doaj.org/article/e8c42cec26b34cbdbfe717df081dc843
Autor:
Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 3, Pp 394-407 (2014)
Gender differences in psychiatric disorders are considered to be associated with the serotonergic (5-HTergic) system; however the underlying mechanisms have not been clearly elucidated. In this study, possible involvement of the median raphe nucleus
Externí odkaz:
https://doaj.org/article/6fa12f9d0c5d42a6b77357505c060299
Autor:
Yu Ohmura, Haruko Kumamoto, Iku Tsutsui-Kimura, Masabumi Minami, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 2, Pp 84-92 (2013)
Higher impulsivity is observed in several psychiatric disorders and could be a risk factor for drug addiction, criminal involvement, and suicide. Although the involvement of the 5-HT1A receptor in impulsive behavior has been indicated, the effects of
Externí odkaz:
https://doaj.org/article/2328dec2d6444e67b7191e8468991a42
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 413-422 (2012)
Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and schizo
Externí odkaz:
https://doaj.org/article/4340a3a8851444b9a3955027755aeab1