Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Mitsuhiro Tsuchiya"'
Autor:
David M Garcia, Edgar A Campbell, Christopher M Jakobson, Mitsuhiro Tsuchiya, Ethan A Shaw, Acadia L DiNardo, Matt Kaeberlein, Daniel F Jarosz
Publikováno v:
eLife, Vol 10 (2021)
In fluctuating environments, switching between different growth strategies, such as those affecting cell size and proliferation, can be advantageous to an organism. Trade-offs arise, however. Mechanisms that aberrantly increase cell size or prolifera
Externí odkaz:
https://doaj.org/article/418f66c5630d4db19a8f8ec90c1a9440
Autor:
Matthew M. Crane, Mitsuhiro Tsuchiya, Ben W. Blue, Jared D. Almazan, Kenneth L. Chen, Siobhan R. Duffy, Alexandra Golubeva, Annaiz M. Grimm, Alison M. Guard, Shauna A. Hill, Ellen Huynh, Ryan M. Kelly, Michael Kiflezghi, Hyunsung D. Kim, Mitchell Lee, Ting-I. Lee, Jiayi Li, Bao M.G. Nguyen, Riley M. Whalen, Feng Y. Yeh, Mark McCormick, Brian K. Kennedy, Joe R. Delaney, Matt Kaeberlein
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss , Pp 104-108 (2019)
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicati
Externí odkaz:
https://doaj.org/article/c89ce9517266486f955ce79743486c70
Autor:
Nairita Maitra, Chong He, Heidi M Blank, Mitsuhiro Tsuchiya, Birgit Schilling, Matt Kaeberlein, Rodolfo Aramayo, Brian K Kennedy, Michael Polymenis
Publikováno v:
eLife, Vol 9 (2020)
A long-standing problem is how cells that lack one of the highly similar ribosomal proteins (RPs) often display distinct phenotypes. Yeast and other organisms live longer when they lack specific ribosomal proteins, especially of the large 60S subunit
Externí odkaz:
https://doaj.org/article/7b9860c6c2c849b8add73fb39e3f0c80
Autor:
Tatsuya Tada, Mitsuhiro Tsuchiya, Kayo Shimada, Tran Thi Thanh Nga, Le Thi Anh Thu, Truong Thien Phu, Norio Ohmagari, Teruo Kirikae
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-7 (2017)
Abstract Methods Twenty-seven clinical isolates of carbapenem-resistant Klebsiella pneumoniae with MICs ≥4 mg/L for imipenem or meropenem were obtained from inpatients in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome se
Externí odkaz:
https://doaj.org/article/3b64c932e9dd4bfaa8f31e7749423f55
Autor:
Tatsuya Tada, Pham Hong Nhung, Kayo Shimada, Mitsuhiro Tsuchiya, Doan Mai Phuong, Nguyen Quoc Anh, Norio Ohmagari, Teruo Kirikae
Publikováno v:
International Journal of Infectious Diseases, Vol 63, Iss C, Pp 72-73 (2017)
The mcr-1 was first detected on a plasmid in colistin-resistant Escherichia coli from livestock and patients in China. We described here the emergence of colistin-resistant E. coli clinical isolates harboring mcr-1 on the chromosomes in Vietnam. To o
Externí odkaz:
https://doaj.org/article/8ebb2e68f58649faa1a34409032a698a
Autor:
Yanhua Yao, Scott Tsuchiyama, Ciyu Yang, Anne Laure Bulteau, Chong He, Brett Robison, Mitsuhiro Tsuchiya, Delana Miller, Valeria Briones, Krisztina Tar, Anahi Potrero, Bertrand Friguet, Brian K Kennedy, Marion Schmidt
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004968 (2015)
Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved protein homeostasis, as this protease is an integral module of the protein homeostasis network. P
Externí odkaz:
https://doaj.org/article/f606e896d6244a9abe38e383f78876be
Autor:
Chong He, Scott K Tsuchiyama, Quynh T Nguyen, Ekaterina N Plyusnina, Samuel R Terrill, Sarah Sahibzada, Bhumil Patel, Alena R Faulkner, Mikhail V Shaposhnikov, Ruilin Tian, Mitsuhiro Tsuchiya, Matt Kaeberlein, Alexey A Moskalev, Brian K Kennedy, Michael Polymenis
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004860 (2014)
The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibupro
Externí odkaz:
https://doaj.org/article/b289025686f24a2eaa090704235ac548
Autor:
Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmidt
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002253 (2011)
Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome syste
Externí odkaz:
https://doaj.org/article/cb26d1c7f14d4479b9b28b8bfe0b4d0f
Autor:
J R Managbanag, Tarynn M Witten, Danail Bonchev, Lindsay A Fox, Mitsuhiro Tsuchiya, Brian K Kennedy, Matt Kaeberlein
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3802 (2008)
Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential
Externí odkaz:
https://doaj.org/article/1995f9d854c74a349ff593adcc968ca4
Autor:
Matt Kaeberlein, Di Hu, Emily O. Kerr, Mitsuhiro Tsuchiya, Eric A. Westman, Nick Dang, Stanley Fields, Brian K. Kennedy
Publikováno v:
PLoS Genetics, Vol 2, Iss 3 (2006)
Externí odkaz:
https://doaj.org/article/71684d4fcc114009bd76babcd76e808b