Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mitsuhiro Kondo"'
Autor:
Hiroshi Tomiyama, Hiroaki Tominaga, Yusuke Wada, Tomohisa Ishikawa, Kenichi Tokita, Kumi Sakairi, Akira Nagashima, Mitsuhiro Kondo
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:428-437
Renal inflammation is a final common pathway of chronic kidney disease (CKD), and its progression can be used to effectively gauge the degree of renal dysfunction. Inflammatory mechanisms contribute to glomerulosclerosis and tubulointerstitial fibros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbc5da7e726e97b6caf3440ad4279f0
https://doi.org/10.1124/jpet.120.265678
https://doi.org/10.1124/jpet.120.265678
Autor:
Hiroyoshi Yamada, Yoshiaki Shimada, Keitaro Kadono, Susumu Yamaki, Akira Nagashima, Mitsuhiro Kondo, Kosei Yoshihara
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6024-6038
Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, we conducted structural optimization of the glycine amide derivative 1, which we previously reported as a novel VAP-1 inhibitor, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2768d2583b652416c99d230030fd786d
https://doi.org/10.1016/j.bmc.2017.09.036
https://doi.org/10.1016/j.bmc.2017.09.036
Autor:
Ayako Moritomo, Kosei Yoshihara, Susumu Yamaki, Mitsuhiro Kondo, Yuji Koga, Yoshiaki Shimada, Keitaro Kadono, Akira Nagashima
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:4110-4122
Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, we conducted optimization studies of our lead compound 1 , which we previously reported as a novel VAP-1 inhibitor, to enhance the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d75a7c95be840d0bbae08b73349c530
https://doi.org/10.1016/j.bmc.2017.05.059
https://doi.org/10.1016/j.bmc.2017.05.059
Autor:
Mitsuhiro Kondo, Atsuo Tahara, Kazumi Hayashi, Takeshi Ishikawa, Hiroshi Inami, Yuichi Tomura
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 393(7)
Renal inflammation is a final common pathway of chronic kidney disease including diabetic nephropathy, which is the leading cause of end-stage renal disease and is associated with high cardiovascular risk and significant morbidity and mortality. Inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad647012b1a1ef977effe9726ace7f0d
https://pubmed.ncbi.nlm.nih.gov/31974740
https://pubmed.ncbi.nlm.nih.gov/31974740
Autor:
Masaki Abe, Keiko Tanaka-Amino, Hikaru Mitori, Megumi Eguchi, Yutaka Inoki, Yusuke Wada, Akira Imasato, Mitsuhiro Kondo, Hiroshi Kajiyama, Toshihide Mimura, Hiroshi Moritani, Yuichi Tomura
Publikováno v:
Experimental Biology and Medicine. 241:1865-1876
Urinary nephrin is a potential non-invasive biomarker of disease. To date, however, most studies of urinary nephrin have been conducted in animal models of diabetic nephropathy, and correlations between urinary nephrin-to-creatinine ratio and other p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcb4e9f45558fa83dcfa524c619221b
https://doi.org/10.1177/1535370216651937
https://doi.org/10.1177/1535370216651937
Publikováno v:
SCSS
We implemented a Mathematica module of CGA which includes functions to denote CGA elements and compute several operations in CGA. We can draw the figure in 3D space which is corresponding to a CGA element. Our draw function is using Gr\"{o}bner Basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f1b212bc626cb28f50331875d86558
https://doi.org/10.29007/6fc5
https://doi.org/10.29007/6fc5
Autor:
Takafumi Akabane, Akira Nagashima, Ayako Moritomo, Jiro Fujiyasu, Susumu Yamaki, Kosei Yoshihara, Keitaro Kadono, Masahiro Neya, Suzuki Daisuke, Mitsuhiro Kondo
Publikováno v:
Bioorganicmedicinal chemistry. 25(1)
Vascular Adhesion Protein-1 (VAP-1) is a promising therapeutic target for the treatment of several inflammatory-related diseases including diabetic microvascular complication. We identified glycine amide derivative 3 as a novel structure with moderat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d6aec64d0e952cb11d45e8532f307
https://pubmed.ncbi.nlm.nih.gov/27810440
https://pubmed.ncbi.nlm.nih.gov/27810440
Publikováno v:
International Immunopharmacology. 7:1528-1534
The species selectivity of four structurally different compounds, SCH-351125, E-913, TAK-779 and UK-427857 has been examined using cloned human, rhesus, and mouse CCR5 receptors. SCH-351125 and E-913 potently inhibited the binding of [125I]-CCL3 to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1de1ba77ab2ffa9de566ca4e560b2fa
https://doi.org/10.1016/j.intimp.2007.07.019
https://doi.org/10.1016/j.intimp.2007.07.019
Autor:
Uchida Koji, Hajime Nakamura, Mitsuhiro Kondo, Takahiro Shibata, Nobuyuki Tanahashi, Takaaki Yamada, Keiji Tanaka, Junji Yodoi, Hiroshi Masutani
Publikováno v:
Biochemistry. 42:13960-13968
Prostaglandin D(2) (PGD(2)), a major cyclooxygenase product in a variety of tissues and cells, readily undergoes dehydration to yield electrophilic PGs, such as 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)). We have previously shown that 15d-PGJ(2) poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc8bf094c61d8c9e1644908b17c9695
https://doi.org/10.1021/bi035215a
https://doi.org/10.1021/bi035215a
Autor:
Mitsuhiro Kondo, Makio Kobayashi, Koji Uchida, Takahiro Shibata, Toshihiko Osawa, Noriyuki Shibata
Publikováno v:
Journal of Biological Chemistry. 277:10459-10466
Prostaglandin D(2) (PGD(2)), a major cyclooxygenase product in a variety of tissues, readily undergoes dehydration to yield the cyclopentenone-type PGs of the J(2) series, such as 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), which have been suggested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13f0a673a5a91adb23fc49d7f33cae36
https://doi.org/10.1074/jbc.m110314200
https://doi.org/10.1074/jbc.m110314200