Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Mitsuhiko Okigaki"'
Autor:
Lina Cipolla, Gianni Francesco Guidetti, Soochong Kim, Mauro Torti, Mitsuhiko Okigaki, Ilaria Canobbio, Satya P. Kunapuli, Caterina Visconte, Daria Manganaro, Marco Falasca
Publikováno v:
Biochemical Journal. 469:199-210
In blood platelets, stimulation of G protein-coupled receptors (GPCRs) by thrombin triggers the activation of Src family kinases (SFKs), resulting in the tyrosine-phosphorylation of multiple substrates, but the mechanism underlying this process is st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8359d56f85dc58b64219be8ba8d307
https://doi.org/10.1042/bj20150048
https://doi.org/10.1042/bj20150048
Autor:
Yoji Taki, Toshiaki Shirahase, Jun Watanabe, Toru Sakatani, Yoshinaga Okumura, Naoto Kuroda, Mitsuhiko Okigaki, Yorika Nakano, Yasushi Adachi, Toshihiro Magaribuchi, Susumu Ikehara
Publikováno v:
Molecular and Clinical Oncology
Mucinous tubular and spindle cell carcinoma (MTSCC) is rare in renal cell carcinoma (RCC) and usually demonstrates a low nuclear grade and a better prognosis compared with other RCCs. The authors present a case report of MTSCC containing an area of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197b4e642dd41d85dac39bed2e2ef052
https://doi.org/10.3892/mco.2017.1430
https://doi.org/10.3892/mco.2017.1430
Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis
Autor:
Kenji Hamaoka, Naohito Ohno, Chinatsu Suzuki, Fuyuki Kametani, Noriko Miura, Mitsuhiko Okigaki, Akihiro Nakamura
Publikováno v:
Clinical Immunology. 153:64-72
Kawasaki disease (KD) is a paediatric idiopathic vasculitis. In this study, on the basis of studies using an established animal model for KD, we report that mannose-binding lectin (MBL) is involved in the pathogenesis of the disease. KD-like experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9ae543982324f2e09459ffe9c3ebb0
https://doi.org/10.1016/j.clim.2014.03.019
https://doi.org/10.1016/j.clim.2014.03.019
Autor:
Soochong Kim, Mitsuhiko Okigaki, Jianguo Jin, Lina Cipolla, Gianni Francesco Guidetti, Satya P. Kunapuli, Mauro Torti
Publikováno v:
Journal of Biological Chemistry. 288:18194-18203
Proline-rich tyrosine kinase 2 (Pyk2) is activated by various agonists in platelets. We evaluated the signaling mechanism and the functional role of Pyk2 in platelets by using pharmacological inhibitors and Pyk2-deficient platelets. We found that pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af0daf257842a1e1e65926cd0b56a76
https://doi.org/10.1074/jbc.m113.461087
https://doi.org/10.1074/jbc.m113.461087
Autor:
Tomomi Ueyama, Maki Katamura, Satoaki Matoba, Mikihiko Nakaoka, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Koji Ikeda, Hiroaki Matsubara, Yoshifumi Okawa, Makoto Ariyoshi, Hideo Nakamura, Mitsuhiko Okigaki, Yuichiro Mita
Publikováno v:
Journal of Molecular and Cellular Cardiology. 52:175-184
Inhibition of tumor suppressor p53 is cardioprotective against ischemic injury and provides resistance to subsequent cardiac remodeling. We investigated p53-mediated expansion of ischemic damage with a focus on mitochondrial integrity in association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f50b01059b8c4e4d0ed1691cb7df522
https://doi.org/10.1016/j.yjmcc.2011.10.008
https://doi.org/10.1016/j.yjmcc.2011.10.008
Autor:
Fang Wang, H. Haeberle, Lincoln V. Johnson, Mark S. Humayun, Eckart Bertelmann, Uwe Pleyer, Frank Tost, Bo Lu, Bruno Diniz, Seiji Yanai, Manoel Odorico de Moraes, Yi-Qiao Xing, Keizo Minamino, Wei Zhou, Kanji Takahashi, David R. Hinton, Anna-Karina B. Maier, Druck Reinhardt Druck Basel, Yuichiro Imai, S. Walter, Lídia Moreira Lima, Padmaja B. Thomas, Mariana Zaira M.L. Ribeiro, Laura Liu, Joao Crispim Moraes Lima Ribeiro, W. Hofmüller, Dennis O. Clegg, Zhi-Qing Wu, Yan-Ning Yang, M. Seibold, Rico Grossjohann, Yuntao Hu, Maria Elisabete Amaral de Moraes, Matthias K. J. Klamann, Chieko Shima, Francisco Vagnaldo Fechine, Satz Mengensatzproduktion, Johannes Gonnermann, Clemens Jürgens, Susumu Ikehara, Ashish Ahuja, Sherry T. Hikita, W. Behrens-Baumann, Ramiro Ribeiro, Yasushi Adachi, I. Tammer, Biju B. Thomas, T. Wecke, K. Tintelnot, Eliezer J. Barreiro, Yu-Chong Tai, Mitsuhiko Okigaki, Danhong Zhu, Julian Philip Klein, Nágila M.P.S. Ricardo, Ming Shi, Antonia M. Joussen
Publikováno v:
Ophthalmic Research. 48:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ced0f530098284fb94316dfa2f14e8
https://doi.org/10.1159/000337110
https://doi.org/10.1159/000337110
Autor:
Kazuo Umezawa, Kazunari Kaneko, Junji Takaya, Tomohiko Shimo, Shoichiro Taniuchi, Mitsuhiko Okigaki, Yasushi Adachi, Susumu Ikehara
Publikováno v:
Clinical and Experimental Immunology. 166:299-306
Summary Dehydroxymethylepoxyquinomicin (DHMEQ), a new nuclear factor (NF)-κB inhibitor, has several beneficial effects, including the suppression of tumour growth and anti-inflammatory effects. DHMEQ can also suppress the production of tumour necros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b1a36906c26e46cd87205ec56025e9
https://doi.org/10.1111/j.1365-2249.2011.04475.x
https://doi.org/10.1111/j.1365-2249.2011.04475.x
Autor:
Ritsuko Kurimoto-Nakano, Koji Ikeda, Satoaki Matoba, Hiroyuki Yamada, Tomomi Ueyama, Maki Uraoka, Yoshiki Akakabe, Masahiro Koide, Yusuke Nakagawa, Hiroaki Matsubara, Mitsuhiko Okigaki, Youhei Kitamura
Publikováno v:
Hypertension. 58:254-263
Ageing is an important risk factor for ischemic cardiovascular diseases, although its underlying molecular mechanisms remain to be elucidated. Here, we report a crucial role of Bcl-2 in the impaired angiogenic functions in senescent endothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d17df83686c2dd72c179ad4c088692
https://doi.org/10.1161/hypertensionaha.111.176701
https://doi.org/10.1161/hypertensionaha.111.176701
Autor:
Tomomi Ueyama, Satoaki Matoba, Youhei Kitamura, Hiroyuki Yamada, Koji Ikeda, Masahiro Koide, Mitsuhiko Okigaki, Yoshiki Akakabe, Hiroaki Matsubara
Publikováno v:
Proceedings of the National Academy of Sciences. 108:9472-9477
Endothelial and endothelial progenitor cells (ECs and EPCs) play a fundamental role in angiogenesis that is essential for numerous physiological and pathological processes. The phosphatase and tensin homolog (PTEN)/ phosphoinositide 3-kinase (PI3K) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7006f46cb2dc13804a0349b92561af64
https://doi.org/10.1073/pnas.1101296108
https://doi.org/10.1073/pnas.1101296108
Autor:
Masayoshi Iwasaki, Akio Shigematsu, Jishan Che, Susumu Ikehara, Ming Shi, Masahiro Imamura, Mitsuhiko Okigaki, Hiroaki Matsubara, Yasushi Adachi, Naoko Koike
Publikováno v:
Stem Cells and Development. 19(11):1679-1686
Fibroblast growth factor (FGF) and FGF receptor (FGFR) are expressed in various cells including endothelial progenitor cells and hematopoietic cells. The interaction between FGF and FGFR is associated with the proliferation, migration, and survival o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e992d3aa1fdc93540efb537666e1949
http://hdl.handle.net/2115/49550
http://hdl.handle.net/2115/49550