Výsledky vyhledávání - "Mitsuharu Hanada"

Abstract 5336: Discovery of a novel activin receptor-like kinases (ALKs) inhibitor targeting TGF-β signaling pathways

Autor: Mai Arai, Mitsuharu Hanada, Hideki Moriyama, Hiroshi Ohmoto, Kazuhito Naka, Masaaki Sawa

Publikováno v: Cancer Research. 83:5336-5336

Introduction: Transforming growth factor β (TGF-β) plays a key role in promoting tumor progression mainly through facilitating angiogenesis, epithelial-mesenchymal transition (EMT) and also inducing immunosuppression in tumor microenvironment, allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05fadc35effeda99581ad810b89f6f63
https://doi.org/10.1158/1538-7445.am2023-5336

Zobrazit plný text záznamu

Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors

Autor: Takayuki Irie, Chika Taniyama, Yuko Uno, Hisao Masai, Mitsuharu Hanada, Masaaki Sawa, Yoko Funakoshi, Tokiko Asami, Ayako Sawa

Publikováno v: European journal of medicinal chemistry. 130

Cdc7 is a serine-threonine kinase and plays a conserved and important role in DNA replication, and it has been recognized as a potential anticancer target. Herein, we report the design, synthesis and structure-activity relationship of novel furanone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c1589d76bf70612dfa8e791ccc61a1
https://pubmed.ncbi.nlm.nih.gov/28279847

Zobrazit plný text záznamu

Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of human hepatoma cells orthotopically implanted in nude rats

Autor: Toshihiro Noguchi, Takashi Yamaoka, Yasuyuki Tsutsumishita, Akemi Baba, Mitsuharu Hanada

Publikováno v: Cancer Science. 100:189-194

Miriplatin is a lipophilic platinum complex which contains myristates as leaving groups and diaminocyclohexane as a carrier ligand. In order to examine in vivo the antitumor activities of miriplatin suspended in an oily lymphographic agent (Lipiodol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832aafedfa5f4f3867cd97b66400d0
https://doi.org/10.1111/j.1349-7006.2008.01010.x

Zobrazit plný text záznamu

Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis

Autor: Fumio Nishikaku, Toshihiro Noguchi, Akemi Baba, Yasuyuki Tsutsumishita, Mitsuharu Hanada, Nobuyoshi Chiba, Takashi Yamaoka

Publikováno v: Cancer Chemotherapy and Pharmacology

Background Miriplatin (formerly SM-11355), a novel lipophilic platinum complex developed to treat hepatocellular carcinoma, is administered into the hepatic artery using an oily lymphographic agent (Lipiodol Ultra-Fluide®) as a carrier. We clarified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c995d9a0b4aad19dfa5c32756b7b1f1
https://doi.org/10.1007/s00280-008-0895-3

Zobrazit plný text záznamu

Amrubicin induces apoptosis in human tumor cells mediated by the activation of caspase-3/7 preceding a loss of mitochondrial membrane potential

Autor: Toshihiro Noguchi, Takashi Yamaoka, Mitsuharu Hanada

Publikováno v: Cancer Science. 97:1396-1403

Amrubicin, a completely synthetic 9-aminoanthracycline derivative, inhibits cell growth by stabilizing a topoisomerase II–DNA complex. This study was designed to examine the apoptosis induced in human leukemia U937 cells by amrubicin and its active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80e7fc0d44d51c913e45ce09ae8bc5e
https://doi.org/10.1111/j.1349-7006.2006.00318.x

Zobrazit plný text záznamu

Uptake and Intracellular Distribution of Amrubicin, a Novel 9-Amino-anthracycline, and Its Active Metabolite Amrubicinol in P388 Murine Leukemia Cells

Autor: Mitsuharu Hanada, Shinya Morisada, Yoshikazu Yanagi, Takashi Yamaoka, Toshihiro Noguchi, Shinji Ichii

Publikováno v: Japanese Journal of Cancer Research : Gann

Amrubicin, a 9‐aminoanthracycline anti‐cancer drug, and its C‐13 hydroxyl metabolite amrubicinol, were examined for growth‐inhibitory activity as well as cellular uptake and distribution in P388 murine leukemia cells and doxorubicin‐resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a961717d280890694075b41c4a34808b
https://doi.org/10.1111/j.1349-7006.1999.tb00801.x

Zobrazit plný text záznamu

A New Antitumor Agent Amrubicin Induces Cell Growth Inhibition by Stabilizing Topoisomerase II-DNA Complex

Autor: Toshihiro Noguchi, Satoko Mizuno, Akihisa Fukushima, Takashi Yamaoka, Yoshikazu Saito, Mitsuharu Hanada

Publikováno v: Japanese Journal of Cancer Research : Gann

Amrubicin is a novel, completely synthetic 9‐aminoanthracycline derivative. Amrubicin and its C‐13 alcohol metabolite, amrubicinol, inhibited purified human DNA topoisomerase II (topo II). Compared with doxorubicin (DXR), amrubicin and amrubicino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ff0953777847cc7c38eaf429591d82
https://doi.org/10.1111/j.1349-7006.1998.tb00519.x

Zobrazit plný text záznamu

Acquired resistance to miriplatin in rat hepatoma AH109A/MP10 is associated with increased Bcl-2 expression, leading to defects in inducing apoptosis

Autor: Mitsuharu Hanada, Hideo Takasu, Makoto Kitaura

Publikováno v: Oncology reports. 24(4)

Miriplatin, a novel lipophilic platinum complex approved to treat hepatocellular carcinoma, is administered into the hepatic artery after suspension in an oily contrast medium. Little is known concerning the mechanism of acquired resistance to miripl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a25406e3a9e3c3f448a6ef87a1fb45
https://pubmed.ncbi.nlm.nih.gov/20811683

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání