Výsledky vyhledávání - "Mitsugu Tomioka"

Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking

Autor: Reiko Kuroda, Yoshiteru Ida, Mitsugu Tomioka, Hiroaki Takayama, Toru Sugiyama, Atsushi Kittaka

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:2847-2851

We here show that single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine (fdU) can crosslink the peptides derived from the DNA binding site of RecA protein through a Schiff base formation. The ability of crosslinking of fdU-containing o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca2e0848fb0b546c0ac70f731e4142e
https://doi.org/10.1016/s0960-894x(03)00593-6

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α-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2(2′-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats

Autor: Mitsugu Tomioka, Chikako Kiyose, Tadahiko Ueda, Kimio Hamamura, Osamu Igarashi, Kazuyo Kaneko, Hisako Saito

Publikováno v: Lipids. 36:467-472

In this study, we investigated a change in the excretory content of 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC), a gamma-tocopherol (gamma-Toc) metabolite, in rat urine and bile by using a new high-performance liquid chromatograp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a61e9fc7c3cd0fc6d5aeae8b4aba7fc
https://doi.org/10.1007/s11745-001-0744-2

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LPS inhibits the intracellular growth of Legionella pneumophila in thioglycolate elicited murine peritoneal macrophages by iron-dependent, tryptophan-independent, oxygen-independent, and arginine-independent mechanisms

Autor: Thomas W. Klein, Yoshimasa Yamamoto, S J Gebran, Herman Friedman, Mitsugu Tomioka, Ray Widen, Catherine Newton

Publikováno v: Journal of Leukocyte Biology. 57:80-87

Thioglycolate-elicited murine macrophages from genetically susceptible A/J mice activated with lipopolysaccharide (LPS) and infected with Legionella pneumophila in vitro evince marked inhibition of intracellular growth of this bacterium. The mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151c954a4c7569b65bae293dcf0dca19
https://doi.org/10.1002/jlb.57.1.80

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The effect of link protein on the rheological properties of solutions of proteoglycan-hyaluronic acid aggregates

Autor: Go Matsumura, Mitsugu Tomioka

Publikováno v: Carbohydrate Polymers. 27:197-203

Proteoglycan monomers, prepared from bovine nasal cartilage, were reassembled with a commercial hyaluronic acid, with or without link protein. The effects of link protein on the rheological properties of proteoglycan aggregates were studied over the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31914a8064505eeee0adddfcf9a94704
https://doi.org/10.1016/0144-8617(95)00046-a

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Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine

Autor: Mitsugu Tomioka, Toru Sugiyama, Atsushi Kittaka, Hiroaki Takayama, Reiko Kuroda, Yoshiteru Ida

Publikováno v: Nucleosides, nucleotidesnucleic acids. 20(4-7)

We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e401d7650e86b177ffcdda6827173e8
https://pubmed.ncbi.nlm.nih.gov/11562961

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Differential effects of granulocyte/macrophage colony-stimulating factor (GM-CSF) in enhancing macrophage resistance to Legionella pneumophila vs Candida albicans

Autor: Mitsugu Tomioka, Yoshimasa Yamamoto, Herman Friedman, Thomas W. Klein

Publikováno v: Cellular immunology. 176(1)

It has been reported that granulocyte/macrophage colony-stimulating factor (GM-CSF), one of the hemopoietic growth factors which regulates the function of phagocytic cells, is a potent activator of cultured macrophages and induces antimicrobial activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270a22a5947780d838a2faae3d9ee341
https://pubmed.ncbi.nlm.nih.gov/9070320

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Separation of unsaturated chondroitin sulfate disaccharides in thin-layer chromatography on silica gel and their quantitative determination by densitometry

Autor: Mitsugu Tomioka, Go Matsumura, Eiji Shimada, Naoko Kudoh

Publikováno v: Chemical and Pharmaceutical Bulletin. 35:1503-1508

A simple and rapid method has been developed to determine the relative amounts of 4-and 6-sulfate in chondroitin sulfate or proteoglycan preparations. Unsaturated disaccharide products derived from the samples by chondroitinase ABC digestion in 0.01

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b006bf973f85285cb296082fef94c299
https://doi.org/10.1248/cpb.35.1503

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Effects of concentration and degree of polymerization on the rheological properties of methylcellulose aqueous solution

Autor: Go Matsumura, Mitsugu Tomioka

Publikováno v: Chemical and Pharmaceutical Bulletin. 35:2510-2518

Rheological studies were carried out on aqueous solutions of five methylcellulose (MC) preparations, with degrees of polymerization (DP) between 330 and 1020. Comparison of the intrinsic viscosity of MC with that of sodium carboxymethylcellulose (CMC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53babc51bf9e2e038d7ecac95b30ab1f
https://doi.org/10.1248/cpb.35.2510

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