Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mitsugu Nakata"'
Autor:
Yoshinori Satomi, Satoshi Yamamoto, Michiyasu Takeyama, Hirokazu Matsumoto, Takashi Yano, Naoya Nishimura, Ryuuichi Nishigaki, Yuki Ooshima, Yoshio Matsumoto, Mitsugu Nakata
Publikováno v:
Transgenic Research. 24:991-1001
The relative proportion of kynurenine aminotransferase (KAT) I-IV activities in the brain is similar between humans and rats. Moreover, KAT II is considered to be the main enzyme for kynurenic acid production in the brain. Taken together, human KAT I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb73f1c45a30708b92674c6428fe370
https://doi.org/10.1007/s11248-015-9909-1
https://doi.org/10.1007/s11248-015-9909-1
Autor:
Yuki Ooshima, Yoshio Matsumoto, Takashi Yano, Satoshi Yamamoto, Tadatoshi Hashimoto, Michiyasu Takeyama, Kunio Matsuoka, Hideki Takahashi, Ryouta Maeda, Mitsugu Nakata, Sayuri Watanabe
Publikováno v:
Transgenic Research. 22:537-547
Gene-targeting technology using mouse embryonic stem (ES) cells has become the "gold standard" for analyzing gene functions and producing disease models. Recently, genetically modified mice with multiple mutations have increasingly been produced to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa09fb68d75d1d71d07c9357e266b735
https://doi.org/10.1007/s11248-012-9651-x
https://doi.org/10.1007/s11248-012-9651-x
Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats
Autor:
Takashi Yano, Satoshi Yamamoto, Tadatoshi Hashimoto, Tadahiro Shinozawa, Michiyasu Takeyama, Mitsugu Nakata, Yasuhiro Tsukimi, Reiko Sasada, Yuki Ooshima, Yoshio Matsumoto
Publikováno v:
Transgenic Research. 21:743-755
One of the remarkable achievements in knockout (KO) rat production reported during the period 2008-2010 is the derivation of authentic embryonic stem (ES) cells from rat blastocysts using a novel culture medium containing glycogen synthase kinase 3 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8756ace0260d5bede8742e09346b03ea
https://doi.org/10.1007/s11248-011-9564-0
https://doi.org/10.1007/s11248-011-9564-0
Autor:
Ritsuko Esaki, Yoshitaka Yasuhara, Kozo Shimakawa, Mitsugu Nakata, Koji Takeuchi, Kimihiko Iwachidow, Takashi Yano, Kae Nagasumi, Hiroyuki Odaka, Kazuhiro Ogi, Shigehisa Taketomi, Yoshihiko Kaisho, Hideyuki Tanaka
Publikováno v:
Diabetes. 58:1067-1076
OBJECTIVE GPR40 is a G protein–coupled receptor regulating free fatty acid–induced insulin secretion. We generated transgenic mice overexpressing the hGPR40 gene under control of the mouse insulin II promoter and used them to examine the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::928c3627d4efbcafed903bce009245d8
https://doi.org/10.2337/db08-1233
https://doi.org/10.2337/db08-1233
Autor:
Yoshihiro Yamada, Naoki Mochizuki, Takashi Yano, Mitsugu Nakata, Ryo Fujii, Masaya Ueno, Nobuyuki Takakura, Hiroyasu Kidoya
Publikováno v:
The EMBO Journal. 27:522-534
Blood vessels change their caliber to adapt to the demands of tissues or organs for oxygen and nutrients. This event is mainly organized at the capillary level and requires a size-sensing mechanism. However, the molecular regulatory mechanism involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65504d5f2b412e6a2fca853cfe8310f5
https://doi.org/10.1038/sj.emboj.7601982
https://doi.org/10.1038/sj.emboj.7601982
Autor:
Yoshio Taniyama, Yoshitaka Yasuhara, Tomoko Satomi, Kozo Shimakawa, Hiromitsu Fuse, Mitsugu Nakata, Sachio Shibata, Shigehisa Taketomi, Masahiko Hattori, Ryuichi Tozawa
Publikováno v:
Biochemical and Biophysical Research Communications. 330:104-110
Human LCAT-like lysophospholipase (LLPL), or lysophospholipase 3, was first identified in vitro, in foam cells derived from THP-1 cells. We demonstrated that LLPL was present in foam cells in the severe atherosclerotic lesions that develop in apolipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73642b58197d7eea3edc2252288381d
https://doi.org/10.1016/j.bbrc.2005.02.126
https://doi.org/10.1016/j.bbrc.2005.02.126
Autor:
Koichi Igarashi, Toshio Abe, Hideaki Tojo, Osamu Shido, Kenji Takami, Yoshihiko Kaisho, Mitsugu Nakata
Publikováno v:
Neuroscience Letters. 192:169-172
We replaced the neurotrophin-3 (NT-3) gene with Escherichia coli-derived lacZ via homologous recombination in embryonic stem (ES) cells and generated the mutant mice. Here we show the in vivo expression of NT-3 in the cerebellum during the postnatal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41da9a4c07be79786de948028519fae0
https://doi.org/10.1016/0304-3940(95)11637-c
https://doi.org/10.1016/0304-3940(95)11637-c
Autor:
Akio Shino, Koichi Igarashi, Kunio Matsuoka, Toshio Abe, Hideaki Tojo, Masayoshi Kitagawa, Kenji Takami, Yoshihiko Kaisho, Osamu Shiho, Shinichi Aizawa, Mitsugu Nakata, Masaki Yamamoto
Publikováno v:
Brain Research. 669:163-175
We have replaced the NT-3 gene with Escherichia coli-derived lacZ gene by means of homologous recombination in embryonic stem cells and thus produced null mutant mice. Mice homozygous for this mutation developed to birth, but most of them could not s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c8df9dfcd77df756c7826715320839
https://doi.org/10.1016/0006-8993(94)01219-8
https://doi.org/10.1016/0006-8993(94)01219-8
Autor:
Shigehisa Taketomi, K. Matsuda-Nagasumi, Yoshitaka Yasuhara, Yoshihiko Kaisho, Shuji Hinuma, Kazuhiro Ogi, Mitsugu Nakata, Takashi Yano, R. Takami-Esaki, Hiroyuki Odaka, Hideyuki Tanaka, Kimihiko Iwachidow
Publikováno v:
Diabetes, obesitymetabolism. 15(6)
Aims G protein-coupled receptor/free fatty acid receptor 1 (GPR40/FFAR1) regulates free fatty acid-induced insulin secretion. This study has been performed to clarify whether or not loss of GPR40/FFAR1 function exacerbates diabetes, that is, whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa82b3f60b82fbbf87a363447582ca8
https://pubmed.ncbi.nlm.nih.gov/23331570
https://pubmed.ncbi.nlm.nih.gov/23331570
Autor:
Hideki Matsui, Yoshitaka Yasuhara, Takashi Yano, Kozo Shimakawa, Yoshihiko Kaisho, Takuya Watanabe, Mitsugu Nakata, Shigehisa Taketomi, Yasuko Terao, Yasufumi Sakura, Ikuo Mori
Publikováno v:
Biochemical and biophysical research communications. 330(3)
The human MrgX3 gene, belonging to the mrgs/SNSRs (mas related genes/sensory neuron specific receptors) family, was overexpressed in transgenic rats using the actin promoter. Two animal lines showed cataracts with liquification/degeneration and swell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f852adf51b86fd2b86dda95da85d979
https://pubmed.ncbi.nlm.nih.gov/15809047
https://pubmed.ncbi.nlm.nih.gov/15809047