Výsledky vyhledávání - "Mitsugu Kiyokawa"

Computer-assisted design and lactonization of model seco-acid derivatives of lankanolide

Autor: Yukinari Kobayashi, Mitsugu Kiyokawa, Osamu Yonemitsu, Junichiro Sano, Toshikazu Yoshioka, Tatsuo Hamada

Publikováno v: Tetrahedron. 60:4693-4704

In some cases, seco-acid derivatives (a precursor of macrolactone) did not cyclize to form the corresponding macrolactone. To design easily cyclizable seco-acid derivatives of lanaknolide, the conformation of several model seco-acids was calculated,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5cfe2f326b7d50b2ef8703034f7f323
https://doi.org/10.1016/j.tet.2004.03.061

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Synthesis and Structure-Activity Relationship of a New Series of Potent Angiotensin II Receptor Antagonists: Pyrazolo(1,5-a)pyrimidine Derivatives

Autor: Takeshi Shiota, Tomoji Kawabata, Mitsugu Kiyokawa, Tsunetoshi Honma, Masafumi Fujimoto, Teruo Yamamori, Masayoshi Ogawa, Natsuki Ishizuka, Katsunori Sakai, Kunio Hayashi, Mariko Hara, Ken-ichi Matsumura, Shigeyuki Nakajima

Publikováno v: Chemical and Pharmaceutical Bulletin. 47:928-938

We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4b5a1bdb93bc4abdba324d44af2208
https://doi.org/10.1248/cpb.47.928

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Nucleosides and nucleotides. 127. A novel and convenient post-synthetic modification method for the synthesis of oligodeoxyribonucleotides carrying amino linkers at the 5-position of 2′-deoxyuridine

Autor: Mitsugu Kiyokawa, Noriaki Minakawa, Noriyasu Haginoya, Akira Ono, Akira Matsuda

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:361-366

5-Methoxycarbonyl-2′-deoxyuridine has been synthesized and incorporated in oligonucleotides. The fully protected oligonucleotides were treated with diaminoethane or diaminohexane and the oligonucleotides were deprotected and purified to give oligon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a1fd00459088983efc2e4aaabc243d9
https://doi.org/10.1016/s0960-894x(01)80145-1

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ChemInform Abstract: Nucleosides and Nucleotides. Part 127. A Novel and Convenient Post- Synthetic Modification Method for the Synthesis of Oligodeoxyribonucleotides Carrying Amino Linkers at the 5-Position of 2′-Deoxyuridine

Autor: Akira Ono, Mitsugu Kiyokawa, Noriyasu Haginoya, Noriaki Minakawa, Akira Matsuda

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aedee9d96c170b47b129c0e20c8bf21f
https://doi.org/10.1002/chin.199427255

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