Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Mitsuaki Yodo"'
1
Homology Modeling of Gelatinase Catalytic Domains and Docking Simulations of Novel Sulfonamide Inhibitors
Autor: Yoshinori Tamura, Mitsuaki Yodo, Tsuzuki Hiroshige, Fumihiko Watanabe, Mitsuaki Ohtani, Ryuichi Kiyama
Publikováno v: Journal of Medicinal Chemistry. 42:1723-1738
Three-dimensional models for the catalytic domain of gelatinases (MMP-9 and -2) have been constructed based on the X-ray crystal structure of MMP-3. Conformations of the loop segment which forms the bottom half of the S1' subsite but shows conformati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdde0dab09c28a5966a89000090fae4
https://doi.org/10.1021/jm980514x
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2
A platform for designing HIV integrase inhibitors. Part 1: 2-hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores
Autor: Mitsuaki Yodo, Takashi Kawasuji, Akihiko Sato, Tomokazu Yoshinaga, Tamio Fujiwara, Ryuichi Kiyama
Publikováno v: Bioorganicmedicinal chemistry. 14(24)
We present a novel series of HIV integrase inhibitors, showing IC(50)s ranging from 0.01 to over 370microM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure-activity relatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aa73073ffd7101173844feb71d9e50
https://pubmed.ncbi.nlm.nih.gov/17010623
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4
The utility of side-chain cyclization in determining the receptor-bound conformation of peptides: cyclic tripeptides and angiotensin II
Autor: Garland R. Marshall, Takahiro Kataoka, John D. Clark, Mitsuaki Yodo, Denise D. Beusen
Publikováno v: Biopolymers. 32(11)
The effect of side-chain cyclization on accessible backbone conformations of tripeptides, X-Ala-Y (X and/or Y = Cys, Hcy (Hcy: homocysteine), cis 4-mercaptoproline (MPc), and trans 4-mercaptoproline (MPt)), was elucidated using two variants of system
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45db8fa141d5695b41c9213f9771e8b7
https://pubmed.ncbi.nlm.nih.gov/1333831
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6
Novel bicycloannulation via tandem vinylation and intramolecular Diels-Alder reaction of five-membered heterocycles: a new approach to construction of psoralen and azapsoralen
Autor: Mitsuaki Yodo, Kenji Hayakawa, Ken Kanematsu, S. Ohsuki
Publikováno v: Journal of the American Chemical Society. 106:6735-6740
Synthese d'heteryl-4 butene-3ones-2(A) par reaction AE de benzenesulfinyl-4 butene-3one-2 avec des furannes, pyrroles, imidazole, pyrazole et dimethylamino-6 fulvenes; par addition de Diels Alder les composes A sont ensuite transformes en furo [3,4-f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8067e3fc6fed6aae3db39fd77c25e33
https://doi.org/10.1021/ja00334a044
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7
Synthesis of methyl 2,3-dihydro-2-benzofurancarboxylates from o-allylphenols via 2-(phenylthiomethyl)-2,3-dihydrobenzofurans
Autor: Mitsuaki Yodo, Hiroshi Harada
Publikováno v: Chemical and Pharmaceutical Bulletin. 37:2361-2368
A method for synthesizing methyl 2,3-dihydro-2-benzofurancarboxylates from o-allylphenols is described. The reaction of 6-allyl-2,3-dichlorophenol, with benzenesulfenyl chloride (PhSCl) in acetonitrile gave a mixture of PhSCl-adducts, which was heate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4234604d980a9a4689e9fc398819677
https://doi.org/10.1248/cpb.37.2361
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8
Optical resolution and chiral synthesis of methyl 6,7-dichloro-2,3-dihydrobenzo(b)furan-2-carboxylate
Autor: Yoshihiro Matsushita, Hiroshi Harada, Eiichi Ohsugi, Mitsuaki Yodo
Publikováno v: Chemical and Pharmaceutical Bulletin. 36:902-913
Optical isomers of methyl 6, 7-dichloro-2, 3-dihydrobenzo[b]furan-2-carboxylate (2) were prepared by means of both optical resolution and chiral synthesis. The resolution of the carboxylic acid 3 was achieved in a practical and efficient way via the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fbbe445413e50e9cafd71ad100b3fa4
https://doi.org/10.1248/cpb.36.902
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10
Studies on uricosuric diuretics. I. 6,7-Dichloro-5-sulfamoyl-2,3-dihydrobenzofuran-2-carboxylic acids
Autor: Yukio Yonetani, Hiroshi Harada, Masuhisa Nakamura, Mitsuaki Yodo, Yoshihiro Matsushita
Publikováno v: Chemical and Pharmaceutical Bulletin. 35:3195-3214
2, 3-Dihydrobenzofuran derivatives having various sulfamoyl groups at the 5-position were synthesized and tested for oral diuretic and saluretic activities in rats and mice. Intraperitoneal uricosuric activity was also tested by a clearance method us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e46127f693b0a653d7bfbf7dd70ecf9
https://doi.org/10.1248/cpb.35.3195
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