Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mitsu Onoma"'
Autor:
Zen Itoh, Hiroyasu Muramatsu, Kenshi Kamei, Satoshi Ōmura, Hisanori Takanashi, Saori Matsuo, Kenji Yogo, Mitsu Onoma, Yoshiki Kawabe, Shuji Hayashi, Makoto Monnai, Masami Suzuki, Toshihiko Shiga, Ken-ichi Ozaki
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 35:788-796
SUMMARY 1 The aim of the present study was to evaluate the effects of mitemcinal (GM-611), an orally active motilin receptor agonist, on delayed gastric emptying in a canine model of diabetic gastroparesis and to compare these effects with those of c
Autor:
Kenshi Kamei, Mitsu Onoma, Hiroyasu Muramatsu, Osamu Kuromaru, Shoshin Yoshida, Theo L. Peeters, Hirokazu Sudo, Osamu Cynshi, Kenji Yogo, Hisanori Takanashi, Ken-ichi Ozaki
Publikováno v:
European Journal of Pharmacology. 581:296-305
The pharmacological properties of MA-2029, a novel motilin receptor antagonist, were investigated. In vitro , MA-2029 (1 to 30 nM) competitively inhibited motilin-induced contractions in isolated rabbit duodenal longitudinal muscle strips, with a pA
Autor:
Jorge E. Herrera, Christiane Thallinger, Mitsu Onoma, Diane Howden, Luis Fernando Ortega-Varela, Paul Goldsmith, G. Tappeiner, Takeshi Sakurai, Li He, Peter Valent, Aylin Köseler, Hiroshi Koga, Munehiro Shiraishi, Stephane Berghmans, Ken-ichi Ozaki, Wolfgang Poeppl, Héctor I. Rocha-González, Ismail H. Ulus, James P. Stables, Frances M. Richards, Kenji Yogo, Zen Itoh, Derek Thomas Edward Jones, Yasuhito Uezono, Barbara Pratscher, Md. Shahidul Islam, Yesim Ozarda Ilcol, Paul E. Newton, Hisanori Takanashi, Jennifer L. Whistler, Nadia L. Caram-Salas, Vinicio Granados-Soto, Matthias Mayerhofer, Satoshi Ōmura, Zoe Golder, Kenshi Kamei, Haymie Choi, Lauren Murphree, Michitaka Akima, Julia Hunt, Christian Joukhadar, Takafumi Horishita, Kouichiro Minami, Yoichi Ueta, Hirokazu Sudo
Publikováno v:
Pharmacology. 79:260-264
Autor:
Zen Itoh, Kenshi Kamei, Satoshi Omura, Mitsu Onoma, Hirokazu Sudo, Ken-ichi Ozaki, Kenji Yogo, Michitaka Akima, Hisanori Takanashi, Hiroshi Koga
Publikováno v:
Pharmacology. 79:223-235
The effects of mitemcinal (GM-611) on the gastrointestinal contractile activity were investigated using chronically implanted force transducers in conscious dogs and were compared with the effects of porcine motilin (pMTL), EM-523 and EM-574. In the
Autor:
Michitaka Akima, Ken-ichi Ozaki, Kenshi Kamei, Kenji Yogo, Hisanori Takanashi, Mitsu Onoma, Hiroshi Koga, Satoshi Omura, Zen Itoh
Publikováno v:
Clinical and experimental pharmacologyphysiology. 35(1)
1. We examined effects of orally administered mitemcinal, an erythromycin-derived motilin agonist, on gastric emptying and antroduodenal motility in conscious normal dogs and conscious dogs with experimentally delayed gastric emptying. For comparison
Autor:
Hisanori Takanashi, Kenji Yogo, Zen Itoh, Masao Koto, Mitsu Onoma, Satoshi Omura, Ken-ichi Ozaki
Publikováno v:
Digestive diseases and sciences. 53(4)
We assessed and compared the effects of oral mitemcinal (an orally active, erythromycin-derived motilin-receptor agonist; Code name: GM-611), erythromycin, EM-574 and cisapride on gastric emptying in conscious Rhesus monkeys using the acetaminophen m
Autor:
Hisanori Takanashi, Kenji Yogo, Zen Itoh, Toshihiko Watanabe, Satoshi Ōmura, Ken-ichi Ozaki, Koichi Katagiri, Yasuhiro Oda, Mitsu Onoma, Hiroyasu Muramatsu, Makoto Monnai, Hitoshi Arakawa
Publikováno v:
Journal of diabetes and its complications. 22(5)
This study was conducted to evaluate the suitability of a new minipig model for investigating aspects of diabetes such as delayed gastric emptying and glucose metabolism abnormalities, and to test the effects of mitemcinal (GM-611), an orally active
Autor:
Takafumi Horishita, Zen Itoh, Zoe Golder, Kenshi Kamei, Wolfgang Poeppl, Nadia L. Caram-Salas, Paul Goldsmith, Li He, Christian Joukhadar, Satoshi Ōmura, James P. Stables, Héctor I. Rocha-González, Yasuhito Uezono, Munehiro Shiraishi, Yesim Ozarda Ilcol, Peter Valent, Jorge E. Herrera, Christiane Thallinger, Vinicio Granados-Soto, Hisanori Takanashi, Jennifer L. Whistler, Md. Shahidul Islam, Matthias Mayerhofer, Mitsu Onoma, Haymie Choi, Hirokazu Sudo, G. Tappeiner, Takeshi Sakurai, Hiroshi Koga, Kouichiro Minami, Paul E. Newton, Yoichi Ueta, Kenji Yogo, Aylin Köseler, Ken-ichi Ozaki, Ismail H. Ulus, Diane Howden, Luis Fernando Ortega-Varela, Stephane Berghmans, Barbara Pratscher, Lauren Murphree, Julia Hunt, Derek Thomas Edward Jones, Frances M. Richards, Michitaka Akima
Publikováno v:
Pharmacology. 79:265-266
Publikováno v:
Metabolism: clinical and experimental. 43(1)
In normal rats, consecutive administrations of AA-193 for 7 days maintained the dose-dependent uricosuric activity without significant changes of the plasma urate level. In clearance studies, AA-193 produced an increase in the fractional excretion of
Autor:
Kenshi Kamei, Zen Itoh, Takashi Dan, Satoshi Omura, Hirokazu Sudo, Hisanori Takanashi, Ken-ichi Ozaki, Mitsu Onoma
Publikováno v:
Japanese Journal of Pharmacology. 82:256