Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mitropoulou, Alkistis N."'
Autor:
Mitropoulou, Alkistis N., Bowen, Holly, Dodev, Tihomir S., Davies, Anna M., Bax, Heather J., Beavil, Rebecca L., Beavil, Andrew J., Gould, Hannah J., James, Louisa K., Sutton, Brian J.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Sep 01. 115(37), E8707-E8716.
Externí odkaz:
https://www.jstor.org/stable/26531327
Autor:
Mitropoulou, Alkistis N.1,2 (AUTHOR), Ceska, Tom3 (AUTHOR), Heads, James T.3 (AUTHOR), Beavil, Andrew J.1,2 (AUTHOR), Henry, Alistair J.3 (AUTHOR), McDonnell, James M.1,2 (AUTHOR) james.mcdonnell@kcl.ac.uk, Sutton, Brian J.1,2 (AUTHOR) brian.sutton@kcl.ac.uk, Davies, Anna M.1,2 (AUTHOR) anna.davies@kcl.ac.uk
Publikováno v:
Acta Crystallographica: Section F, Structural Biology Communications. Mar2020, Vol. 76 Issue 3, p116-129. 14p.
Autor:
Chen, Jiun-Bo, Ramadani, Faruk, Pang, Marie O. Y., Beavil, Rebecca L., Holdom, Mary D., Mitropoulou, Alkistis N., Beavil, Andrew J., Gould, Hannah J., Chang, Tse Wen, Sutton, Brian J., McDonnell, James M., Davies, Anna M.
Publikováno v:
Chen, J-B, Ramadani, F, Pang, M O Y, Beavil, R L, Holdom, M D, Mitropoulou, A N, Beavil, A J, Gould, H J, Chang, T W, Sutton, B J, McDonnell, J M & Davies, A M 2018, ' Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody ', Scientific Reports, vol. 8, no. 1, 11548 . https://doi.org/10.1038/s41598-018-29664-4
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Immunoglobulin E (IgE) antibodies play a central role in the allergic response: interaction with FcεRI on mast cells and basophils leads to immediate hypersensitivity reactions upon allergen challenge, while interaction with CD23/FcεRII, expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::14e5f64ba681ca378c5f613bda1307fa
https://kclpure.kcl.ac.uk/en/publications/9f48eecf-6631-4720-9e1c-34478ed33a1b
https://kclpure.kcl.ac.uk/en/publications/9f48eecf-6631-4720-9e1c-34478ed33a1b
Autor:
Davies, Anna M., Allan, Elizabeth G., Keeble, Anthony H., Delgado, Jean, Cossins, Benjamin P., Mitropoulou, Alkistis N., Pang, Marie O. Y., Ceska, Tom, Beavil, Andrew J., Craggs, Graham, Westwood, Marta, Henry, Alistair J., McDonnell, James M., Sutton, Brian J.
Publikováno v:
Davies, A M, Allan, E G, Keeble, A H, Delgado, J, Cossins, B P, Mitropoulou, A N, Pang, M O Y, Ceska, T, Beavil, A J, Craggs, G, Westwood, M, Henry, A J, McDonnell, J M & Sutton, B J 2017, ' Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab ', Journal of Biological Chemistry, vol. 292, no. 24, pp. 9975–9987 . https://doi.org/10.1074/jbc.M117.776476
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Immunoglobulin E and its interactions with receptors FcϵRI and CD23 play a central role in allergic disease. Omalizumab, a clinically approved therapeutic antibody, inhibits the interaction between IgE and FcϵRI, preventing mast cell and basophil a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1db23bdec5864c2332f1a27605a1219
https://kclpure.kcl.ac.uk/ws/files/72119846/Allosteric_mechanism_of_action_DAVIES_Publishedonline24April2017_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/72119846/Allosteric_mechanism_of_action_DAVIES_Publishedonline24April2017_GOLD_VoR_CC_BY_.pdf
Akademický článek
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Autor:
Chen JB; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom., Ramadani F; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Pang MOY; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Beavil RL; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma Protein Production Facility, London, United Kingdom., Holdom MD; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Mitropoulou AN; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Beavil AJ; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Gould HJ; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Chang TW; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan., Sutton BJ; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom. brian.sutton@kcl.ac.uk.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. brian.sutton@kcl.ac.uk., McDonnell JM; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom. james.mcdonnell@kcl.ac.uk.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. james.mcdonnell@kcl.ac.uk., Davies AM; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom. anna.davies@kcl.ac.uk.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. anna.davies@kcl.ac.uk.
Publikováno v:
Scientific reports [Sci Rep] 2018 Aug 01; Vol. 8 (1), pp. 11548. Date of Electronic Publication: 2018 Aug 01.
Autor:
Davies AM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Allan EG; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Keeble AH; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Delgado J; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Cossins BP; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Mitropoulou AN; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Pang MOY; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Ceska T; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Beavil AJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Craggs G; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Westwood M; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Henry AJ; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., McDonnell JM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, james.mcdonnell@kcl.ac.uk.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Sutton BJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, brian.sutton@kcl.ac.uk.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2017 Jun 16; Vol. 292 (24), pp. 9975-9987. Date of Electronic Publication: 2017 Apr 24.