Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents

Autor: Oakley C. Olson, Emily A. Foley, Daniela F. Quail, Hyunjung Kim, Johanna A. Joyce

Publikováno v: Cell Reports, Vol 19, Iss 1, Pp 101-113 (2017)
Cell reports
Cell reports, vol. 19, no. 1, pp. 101-113

SUMMARY Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee853eeb173592355999915e797db366
http://www.sciencedirect.com/science/article/pii/S2211124717303844

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

Autor: Tamas L. Horvath, Maria Teresa Dell’Anno, Xiao-Bing Gao, Naoki Nakagawa, Anze Testen, Yalan Zhang, Tianliuyun Gao, Mihovil Pletikos, Candace Bichsel, Nenad Sestan, Mingfeng Li, Sirisha Pochareddy, Brett D. Lindenbach, Leonard K. Kaczmarek, Zhen Li, Wenqi Han, Forrest O. Gulden, Fuchen Liu, André M. M. Sousa, Stephen M. Strittmatter, Andrew T.N. Tebbenkamp, Marco Onorati, Steven Lisgo, Jernej Mlakar, Marie Flamand, Mara Popović, Eva S. Anton, Luis Varela, Klara Szigeti-Buck, Ying Zhu

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 16 (10), pp.2576-2592. ⟨10.1016/j.celrep.2016.08.038⟩
Cell Reports, 2016, 16 (10), pp.2576-2592. ⟨10.1016/j.celrep.2016.08.038⟩
Cell Reports, Vol 16, Iss 10, Pp 2576-2592 (2016)

SummaryThe mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8842a91c108e53c206bfa4ca694b4d28
https://hal-pasteur.archives-ouvertes.fr/pasteur-01739212

p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment

Autor: Håkon Kirkeby Buch, Robert S. Hagan, Michelle G. Meier, Jagesh V. Shah, Patrick Meraldi, Michael S. Manak, Peter K. Sorger

Publikováno v: Molecular Biology of the Cell, 22 (22)
Molecular Biology of the Cell
Molecular Biology of the Cell, Vol. 22, No 22 (2011) pp. 4236-46

The spindle assembly checkpoint links the onset of anaphase to completion of chromosome-microtubule attachment and is mediated by the binding of Mad and Bub proteins to kinetochores of unattached or maloriented chromosomes. Mad2 and BubR1 traffic bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b3123c1e80770c93b894a1557a9dd6
https://hdl.handle.net/20.500.11850/40677

Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase

Autor: Yang, H., Zheng, S., S. M., Li, Leclerc, S., L. L.Bach S., Yu, Knockaert, M., Reinhardt, J., Lozach, O., Schmitt, S., Baratte, B., Koken, M., S. P., Coburn, Tang, L., Jiang, T., D. C., Liang, Galons, H., J. F., Dierick, L. A., Pinna, Meggio, F., Totzke, F., Schachtele, C., Lerman, A. S., Carnero, A., Wan, Y., Gray, N., Meijer, L., J. Q., Cheng, S. Z., Zhang

Publikováno v: Journal of Zhejiang University. Science
Journal of Zhejiang University. Science, 2005, 6, pp.656-63

OBJECTIVE: To screen and evaluate the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 phosphatase. METHODS: The affinity chromatography purified glutashione-S-transferase/Cdc25A phosphatase fusion protein and Cdc2/cyclin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c464c547a14748202dabd8a522d32234
https://hal.archives-ouvertes.fr/hal-00018682

Vitamin C transiently arrests cancer cell cycle progression in S phase and G2/M boundary by modulating the kinetics of activation and the subcellular localization of Cdc25C phosphatase

Autor: Thomas, C. G., Vezyraki, P. E., Kalfakakou, V. P., Evangelou, A. M.

Regulation of cell cycle progression involves redox (oxidation-reduction)-dependent modification of proteins including the mitosis-inducing phosphatase Cdc25C. The role of vitamin C (ascorbic acid, ASC), a known modulator of the cellular redox status

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::885db94970c543c71ff9b9f9de77a363
http://olympias.lib.uoi.gr/jspui/handle/123456789/24561