Zobrazeno 1 - 10
of 511
pro vyhledávání: '"Mitochondrial transplantation"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction is a crit
Externí odkaz:
https://doaj.org/article/4d2f0a39676b46b0a695cf4d507923e4
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 4089-4116 (2024)
Feiyu Gao,* Tao Xu,* Fangnan Zang, Yuanyuan Luo, Defeng Pan Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China*These authors contributed equally to this wo
Externí odkaz:
https://doaj.org/article/43e1626fe91043b9a55341759e52c04b
Autor:
Danielle L. Tomasello, M. Inmaculada Barrasa, David Mankus, Katia I. Alarcon, Abigail K. R. Lytton-Jean, X. Shawn Liu, Rudolf Jaenisch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-27 (2024)
Abstract Studies on MECP2 function and its implications in Rett Syndrome (RTT) have traditionally centered on neurons. Here, using human embryonic stem cell (hESC) lines, we modeled MECP2 loss-of-function to explore its effects on astrocyte (AST) dev
Externí odkaz:
https://doaj.org/article/504471da9d3c4319ac418eab244a6290
Autor:
Cai‐Ju Zhang, Jia‐Mi Li, Dan Xu, Dan‐Dan Wang, Ming‐Hui Qi, Feng Chen, Bo Wu, Kai Deng, Shi‐Wen Huang
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Reprogramming tumor‐associated macrophages (TAMs) to an inflammatory phenotype effectively increases the potential of immune checkpoint blockade (ICB) therapy. Artificial mitochondrial transplantation, an emerging and safe strategy, has ma
Externí odkaz:
https://doaj.org/article/10da66c8cc1a4ce6aded61b7531a7b61
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background DNA damage and oxidative stress induced by chemotherapy are important factors in the onset of premature ovarian insufficiency (POI). Studies have shown that mitochondria derived from mesenchymal stem cells (MSC-Mito) are beneficia
Externí odkaz:
https://doaj.org/article/7d6107b8fb57452f956896aaa805edf9
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 14, Iss 1, Pp 147-160 (2024)
Purpose: Both aging and neurodegenerative illnesses are thought to be influenced by mitochondrial malfunction and free radical formation. Deformities of the energy metabolism, mitochondrial genome polymorphisms, nuclear DNA genetic abnormalities asso
Externí odkaz:
https://doaj.org/article/724fe7d3f50142f98d7d20a1bf36b75f
Autor:
Pasquale Picone, Emanuela Muscolino, Antonella Girgenti, Maria Testa, Daniela Giacomazza, Clelia Dispenza, Domenico Nuzzo
Publikováno v:
Carbohydrate Polymer Technologies and Applications, Vol 8, Iss , Pp 100543- (2024)
Mitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including regulating metabolism and maintaining cellular homeostasis. Mitochondrial dysfunction is as
Externí odkaz:
https://doaj.org/article/e44ff2100c1d4eeaa0a1cc3606011631
Autor:
Mir-Jamal Hosseini, Aysan Hassanbeigloo, Hamideh Abbasi, Abdollah Arjmand, Fatemeh Sherkat, Jalal Pourahmad
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101669- (2024)
Tenofovir, as nucleotide reverse transcriptase inhibitors (NRTIs), is used to prevent and cure HIV/AIDS. Ample evidence confirmed that the nephrotoxicity of tenofovir has been linked to mitochondrial dysfunction. It seems that transplantation with he
Externí odkaz:
https://doaj.org/article/96c65aa9387643d68b84a087a4c9a67c
Autor:
Jiaqi Xu, Chaoran Shi, Feifei Yuan, Yinghe Ding, Yong Xie, Yudong Liu, Fengzhang Zhu, Hongbin Lu, Chunyue Duan, Jianzhong Hu, Liyuan Jiang
Publikováno v:
Bioactive Materials, Vol 32, Iss , Pp 427-444 (2024)
Mitochondria are crucial in sustaining and orchestrating cellular functions. Capitalizing on this, we explored mitochondrial transplantation as an innovative therapeutic strategy for acute spinal cord injury (SCI). In our study, we developed an engin
Externí odkaz:
https://doaj.org/article/748b55273008495ba1522fd5f6858966
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