Výsledky vyhledávání - "Mitochondrial redox"

Akademický článek

Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms

Autor: Jinyuan Lin, Huajin Ou, Bijun Luo, Maoyao Ling, Fei Lin, Liming Cen, Zhaokun Hu, Liu Ye, Linghui Pan

Publikováno v: Molecular Medicine, Vol 30, Iss 1, Pp 1-18 (2024)

Abstract Background Ventilator-induced lung injury (VILI) is one of the severe complications in the clinic concerning mechanical ventilation (MV). Capsaicin (CAP) has anti-inflammatory and inhibitory effects on oxidative stress, which is a significan

Externí odkaz: https://doaj.org/article/7d01df2b1266477980e3e90c84c4fb5b

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Akademický článek

Use of Optical Redox Imaging to Quantify Alveolar Macrophage Redox State in Infants: Proof of Concept Experiments in a Murine Model and Human Tracheal Aspirates Samples

Autor: He N. Xu, Diego Gonzalves, Jonathan H. Hoffman, Joseph A. Baur, Lin Z. Li, Erik A. Jensen

Publikováno v: Antioxidants, Vol 13, Iss 5, p 546 (2024)

Emerging data indicate that lung macrophages (LM) may provide a novel biomarker to classify disease endotypes in bronchopulmonary dysplasia (BPD), a form of infant chronic lung disease, and that augmentation of the LM phenotype may be a potential the

Externí odkaz: https://doaj.org/article/f3ba5817649f44478be2ef2467c3502f

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Akademický článek

Downregulation of TAZ elicits a mitochondrial redox imbalance and ferroptosis in lung epithelial cells exposed to diesel exhaust particles

Autor: Kang-Yun Lee, Ching-Chieh Yang, Pei-Wei Shueng, Sheng-Min Wu, Chih-Hsuan Chen, Yi-Chun Chao, Yu-Chu Chang, Chia-Li Han, Hsiao-Chi Chuang, Chi-Ching Lee, Cheng-Wei Lin

Publikováno v: Ecotoxicology and Environmental Safety, Vol 266, Iss , Pp 115555- (2023)

Mitochondrial dysfunction was reported to be involved in the development of lung diseases including chronic obstructive pulmonary disease (COPD). However, molecular regulation underlying metabolic disorders in the airway epithelia exposed to air poll

Externí odkaz: https://doaj.org/article/d71ae3198f244e15bd669124fece0090

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Akademický článek

Mitochondrial dysfunction and calcium dyshomeostasis in the pectoralis major muscle of broiler chickens with wooden breast myopathy

Autor: Xinrui Zhang, Tong Xing, Jiaolong Li, Lin Zhang, Feng Gao

Publikováno v: Poultry Science, Vol 102, Iss 9, Pp 102872- (2023)

ABSTRACT: The incidence of wooden breast (WB) meat of commercial broiler chicken has been increasing in recent years. Histological examination found that the occurrence of WB myopathy was accompanied by the pectoralis major (PM) muscle damage. So far

Externí odkaz: https://doaj.org/article/0698aefbb4c147b0b206a43ad81be2ec

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Akademický článek

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Akademický článek

Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer

Autor: Versha Tripathi, Pooja Jaiswal, Khageswar Sahu, Shovan Kumar Majumder, Dharmendra Kashyap, Hem Chandra Jha, Amit Kumar Dixit, Hamendra Singh Parmar

Publikováno v: Advances in Cancer Biology - Metastasis, Vol 6, Iss , Pp 100065- (2022)

Background: As per facts sheet of WHO, cancer is a leading cause of mortality worldwide accounting nearly 10 million deaths in 2020. However, breast, lung, colon and rectum, prostate, skin and stomach cancers are the six most prevailing cancer across

Externí odkaz: https://doaj.org/article/fcd5a0825b8f4a5f94c5d739fafea854

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Akademický článek

Early label-free analysis of mitochondrial redox states by Raman spectroscopy predicts septic outcomes

Autor: Meiyan Wu, Kairui Pu, Tao Jiang, Qian Zhai, Zhi Ma, Hongli Ma, Fuxing Xu, Zhanqin Zhang, Qiang Wang

Publikováno v: Journal of Advanced Research, Vol 28, Iss , Pp 209-219 (2021)

Background: Sepsis remains an unacceptably high mortality due to the lack of biomarkers for predicting septic outcomes in the early period. Mitochondrial redox states play a pivotal role in this condition and are disturbed early in the development of

Externí odkaz: https://doaj.org/article/ad37164faddd4f48b20ca958cfcc36e7

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Akademický článek

Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity

Autor: Liling Su, Wenpan Fang, Xinyuan Zhao, Longtao Zhu, Lan Gao, Guangdi Chen

Publikováno v: Ecotoxicology and Environmental Safety, Vol 237, Iss , Pp 113519- (2022)

Occupational and environmental Sb exposure has been associated with increased risk of respiratory diseases and lung cancer, but the toxicities and molecular mechanisms of Sb have been less investigated. In the present study, we first analyzed the Sb

Externí odkaz: https://doaj.org/article/2a91253be6874a28a9248f9d78a019f5

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Akademický článek

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

Autor: David B. Stagg, Jacob R. Gillingham, Alisa B. Nelson, Justin E. Lengfeld, D. André d’Avignon, Patrycja Puchalska, Peter A. Crawford

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101269- (2021)

Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents. However, the regulatory roles of

Externí odkaz: https://doaj.org/article/fb28ca13065f4109842eeb324b00f0c4

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