Environmental triggers for connective tissue disease: the case of COVID-19 associated with dermatomyositis-specific autoantibodies

Autor: Carlo Selmi, Ezio Lanza, Francesca Motta, Angela Ceribelli, Elena Azzolini, Caterina Ricordi, Antonio Voza, Salvatore Badalamenti, Natasa Isailovic, Maria De Santis

Publikováno v: Current opinion in rheumatology. 33(6)

PURPOSE OF REVIEW: The aim of the present review is to analyze the link between autoimmune diseases and environmental factors, in particular severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) as it shares numerous featu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c71f03103f06ae85e5a3987bbfed9e
https://pubmed.ncbi.nlm.nih.gov/34506341

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition

Autor: Siddharth Jayaraman, Edith Paxton, Harry P. de Koning, Kathryn Crouch, Omar A. Alfituri, Pieter C. Steketee, Catarina Gadelha, Ryan Ritchie, Emily A. Dickie, Michael P. Barrett, Achim Schnaufer, Bill Wickstead, T.G Rowan, Liam J. Morrison, Georgina Awuah-Mensah, James Iremonger

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)
Steketee, P, Dickie, E A, Iremonger, J, Crouch, K, Paxton, E, Jayaraman, S, Alfituri, O, Awuah-Mensah, G, Ritchie, R, Schnaufer, A, Rowan, T, De Koning, H P, Gadelha, C, Wickstead, B, Barrett, M P & Morrison, L 2021, ' Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition ', PLoS Pathogens, vol. 17, no. 7, e1009734 . https://doi.org/10.1371/journal.ppat.1009734

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09479fd9ae271c20c8eba737e0d0d06b
http://europepmc.org/articles/PMC8384185

GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

Autor: Annika Pfeiffer, Eva-Maria Hanschmannn, Jonas Schwirz, Sara Bitar, Ibrahim Boussaad, Oliver Brüstle, Kristina Dobrindt, Caterina Vianello, Diones Caeran Bueno, Michael Peitz, Alireza Pouya, Christina Wolf, Stefan Tenzer, Rejko Krüger, Marta Giacomello, Sandra Ritz, Federica Dal Bello, Axel Methner, Sabine Arndt

Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61d5f3c035b64521c93d8c55a7eb823e
https://doi.org/10.21203/rs.3.rs-209468/v1

Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function

Autor: Krishna K. Varadhan, Dileep N. Lobo, Paul L. Greenhaff, Dumitru Constantin-Teodosiu, Despina Constantin, Ryan P. Atkins

Publikováno v: Clinical Nutrition (Edinburgh, Scotland)

© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60f297c96e45ed8ad162f41f06b8100

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications

Autor: Hongmin Li, Xiaoyue Shen, Xiuxiu Wang, Yuting Yan

Publikováno v: Bioscience Reports

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe5927b8cf49db51f1178b895ab7760
https://pubmed.ncbi.nlm.nih.gov/33739396