Zobrazeno 1 - 10
of 668
pro vyhledávání: '"Mitochondrial oxidative phosphorylation"'
Autor:
Yingying Lin, Yao Lu, Yuqi Wang, Cong Lv, Juan Chen, Yongting Luo, Heng Quan, Weiru Yu, Lining Chen, Ziyu Huang, Yanling Hao, Qingyu Wang, Qingfeng Luo, Jingyu Yan, Yixuan Li, Wei Zhang, Min Du, Jian He, Fazheng Ren, Huiyuan Guo
Publikováno v:
Engineering, Vol 42, Iss , Pp 39-58 (2024)
Intestinal stem cells (ISCs) initiate intestinal epithelial regeneration and tumorigenesis, and they experience rapid refilling upon various injuries for epithelial repair as well as tumor reoccurrence. It is crucial to reveal the mechanism underlyin
Externí odkaz:
https://doaj.org/article/ff2a7a8c828743658905b2c6f63df3f4
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Background Inflammation and endothelial barrier dysfunction are the major pathophysiological changes in acute respiratory distress syndrome (ARDS). Sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor, has been found to m
Externí odkaz:
https://doaj.org/article/32ffabffc0994b17887acc9802ed5d2f
Autor:
Bertil Ladefoged, Anders Dahl Pedersen, Jacob Seefeldt, Bent Roni Ranghøj Nielsen, Hans Eiskjær, Emil Lichscheidt, Tor Clemmensen, Julian David Gillmore, Steen Hvitfeldt Poulsen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background Wild‐type transthyretin amyloid (ATTRwt) cardiomyopathy is increasingly recognized in the development of heart failure. The link between cardiac performance, hemodynamics, and mitochondrial function in disease stages of ATTRwt has not pr
Externí odkaz:
https://doaj.org/article/36e4897fdd884b93ac55e5daa71d5e5b
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 597-606 (2024)
The aryl hydrocarbon receptor (AHR) has been identified as a significant driver of tumorigenesis. However, its clinical significance in acute myeloid leukemia (AML) remains largely unclear. In this study, RNA-Seq data from AML patients (bone marrow s
Externí odkaz:
https://doaj.org/article/3b049a573eeb4c13a3037d2807609fa6
Autor:
Dominik T. Koch, Haochen Yu, Iris Beirith, Malte Schirren, Moritz Drefs, Yunfei Liu, Mathilda Knoblauch, Dionysios Koliogiannis, Weiwei Sheng, Enrico N. De Toni, Alexandr V. Bazhin, Bernhard W. Renz, Markus O. Guba, Jens Werner, Matthias Ilmer
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract Background Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis. The feasibility of potentially curative liver resection (LR) and
Externí odkaz:
https://doaj.org/article/89af6ca6afb242988daf6262b04f125d
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27427- (2024)
Background: The predominant feature of cancer cells during the process of carcinogenesis is the inclination towards glycolytic metabolism rather than mitochondrial oxidative phosphorylation. Nevertheless, there is a scarcity of research investigating
Externí odkaz:
https://doaj.org/article/15b0aa92da1d4eebbd7053a1b1dd3df6
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insul
Externí odkaz:
https://doaj.org/article/7cc4055c18a44f019b6e27247daf290a
Autor:
Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Sang Min Jeon, In Soo Kim, June-Young Lee, Jun Young Heo, Sang-Hee Lee, Jin-Woo Bae, Jin-Man Kim, Jin Bong Park, Eun-Kyeong Jo
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Gamma-aminobutyric acid type A receptor (GABAAR), the ionotropic receptor of GABA, is expressed in macrophages and in the nervous system; however, its role in innate immunity is unknown. Herein, we identified myeloid GABAAR subunit α4 (Gabra4) as a
Externí odkaz:
https://doaj.org/article/93629026a01e44d08b5dff1516a0aed7
Autor:
Juanjuan Feng, Zhengke Lian, Xinting Xia, Yue Lu, Kewen Hu, Yunpeng Zhang, Yanan Liu, Longmiao Hu, Kun Yuan, Zhenliang Sun, Xiufeng Pang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1145-1163 (2023)
MEK is a canonical effector of mutant KRAS; however, MEK inhibitors fail to yield satisfactory clinical outcomes in KRAS-mutant cancers. Here, we identified mitochondrial oxidative phosphorylation (OXPHOS) induction as a profound metabolic alteration
Externí odkaz:
https://doaj.org/article/330cb01aa91d4b50ae4c436b870a5b24
Autor:
Zaigang Zhou, Jiashe Chen, Yu Liu, Chunjuan Zheng, Wenjuan Luo, Lele Chen, Shen Zhou, Zhiming Li, Jianliang Shen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 11, Pp 4204-4223 (2022)
As a promising modality for cancer therapy, photodynamic therapy (PDT) still acquired limited success in clinical nowadays due to the extremely serious hypoxia and immunosuppression tumor microenvironment. To ameliorate such a situation, we rationall
Externí odkaz:
https://doaj.org/article/3a34d31bf2e84a9e85a13848c83de36c