Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Mitochondrial outer membrane permeabilization"'
Autor:
Bruno Cesar Costa Soares, Hnin Ei Ei Khine, Boonchoo Sritularak, Pithi Chanvorachote, Rosa Alduina, Rungroch Sungthong, Chatchai Chaotham
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: The upgrade of natural products for cancer treatment is essential since current anticancer drugs still pose severe side effects. Cymensifin A (Cym A) isolated from an orchid Cymbidium ensifolium has shown its potential to induce the death
Externí odkaz:
https://doaj.org/article/5541f24e39bd48deaa09a3a4d79e7318
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis. BAX, a proapoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial membrane to activate the mitoch
Externí odkaz:
https://doaj.org/article/ad1c5e974e5b4f44951c3ad2fc7fdb0e
Autor:
Prasad Sulkshane, Tanuja Teni
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 3, Pp 278-296 (2022)
The antiapoptotic B cell lymphoma-2 (Bcl-2) family members are apical regulators of the intrinsic pathway of apoptosis that orchestrate mitochondrial outer membrane permeabilization (MOMP) through interactions with their proapoptotic counterparts. Ov
Externí odkaz:
https://doaj.org/article/93986c4e1e2c4b9ebc28fc2e922f3483
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features o
Externí odkaz:
https://doaj.org/article/a0a3bdfe79184dedbcc355b0d9ece19c
Akademický článek
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Autor:
Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Osterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 9 (2020)
The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the m
Externí odkaz:
https://doaj.org/article/3930186c3fd04ad4a33907088e2464c2
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon
Externí odkaz:
https://doaj.org/article/2d71e7a5474046659e407ad88d85df7a
Autor:
Alexey S. Ladokhin
Publikováno v:
Cells, Vol 9, Iss 9, p 2121 (2020)
Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]
Externí odkaz:
https://doaj.org/article/11c6cdf56600498eb1e66a36f9b567fb
Akademický článek
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Publikováno v:
Cellular and Molecular Life Sciences
Apoptotic cell death is essential for development, immune function or tissue homeostasis, and its mis-regulation is linked to various diseases. Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b9cc4cabb7e0a4470d199f71f3046
http://europepmc.org/articles/PMC8106609
http://europepmc.org/articles/PMC8106609