Zobrazeno 1 - 10
of 3 741
pro vyhledávání: '"Mitochondrial apoptosis"'
Publikováno v:
Fushe yanjiu yu fushe gongyi xuebao, Vol 42, Iss 4, Pp 64-74 (2024)
We investigated the effects of mitochondrial damage via carbon ion irradiation on the proliferation of human non-small cell lung cancer (A549) cells by monitoring mitochondrial morphological changes, mitochondrial membrane potential transformation, r
Externí odkaz:
https://doaj.org/article/11142418b6ac4141b467e9621fec3a55
Autor:
Xu Jia, Danting Mao, Jianwei Guo, Jiangyu Ke, Yanlin Zhu, Xiaoyang Zhao, Ziren Luo, Xinghai Liu, Rui Tang, Ruihan Hou, Haitao Lan, Qian zheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Long-term exposure to hyperglycemic conditions leads to β-cell dysfunction, particularly mitochondrial dysfunction, and inflammatory and oxidative stress responses, which are considered the primary causes of β-cell death and the hallmarks
Externí odkaz:
https://doaj.org/article/0a7e093681f9453e8c355ffd13e3da01
Autor:
Fengxia CHEN, Feifei PU
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 7, Pp 554-560 (2024)
ObjectiveTo investigate the effect of folic acid–modified liposome quercetin (FLQ) on the proliferation and apoptosis of triple negative breast cancer (TNBC) cells and explore its underlying mechanism. MethodsCCK-8 was used to detect the effect of
Externí odkaz:
https://doaj.org/article/68e92d828f4446f4a3477baf0e8b046a
Autor:
Desheng Li, Xiaoqing Yuan, Jianjun Ma, Tao Lu, Jinjin Zhang, Huan Liu, Guanqing Zhang, Yue Wang, Xiaohan Liu, Qiqiang Xie, Ling Zhou, Maolei Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117510- (2024)
Objective: Morusin (Mor), a prenylated flavonoid isolated from the root bark of Morus alba L., exhibits potent anti-tumour effects; however, the molecular target of Mor is still not entirely clear. This study aimed to elucidate the mechanism of Mor a
Externí odkaz:
https://doaj.org/article/7eab8ac3ef8343caa6a9eb0fd6af5de6
Autor:
Jiaxin Chen, Haoyi Cheng, Chunhua Bai, Dandan Wang, Jinghao Fu, Jinge Hao, Yixuan Wang, Zhang Xuewu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
4′,5,7-Trihydroxy-8-methoxyflavone is an anticancer monomer component isolated from the traditional Chinese medicine Sorbaria sorbifolia. 4′,5-Dihydroxy-7-piperazinemethoxy-8-methoxy flavonoids (DMF) with good solubility and anti-tumor effects wa
Externí odkaz:
https://doaj.org/article/9fab8194afe34cab916b3d80cf70effa
Publikováno v:
Chinese Medicine and Natural Products, Vol 04, Iss 03, Pp e117-e125 (2024)
Objective The aim of the study was to investigate the effects of Chinese herbal formula Weichang'an (WCA) on the proliferation and mitochondria-mediated apoptosis of human gastric cancer cells.
Externí odkaz:
https://doaj.org/article/b1ba950f31bc4e4792a47eb019daa2a3
Autor:
Siyue Jiang, Pengjiao Wang, Xiaodong Sun, Min Zhang, Shuo Zhang, Yu Cao, Yuben Wang, Li Liu, Xiuli Gao
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundLeukopenia can be caused by chemotherapy, which suppresses bone marrow function and can impact the effectiveness of cancer treatment. Qijiao Shengbai Capsule (QJSB) is commonly used to treat leukopenia, but the specific bioactive components
Externí odkaz:
https://doaj.org/article/0b6272f5f3fc44f7a6820fa1309c67e0
Autor:
Jingyu Wang, Ruina Zhao, Yang Liu, Tieying Hu, Xiaolong Li, Long He, Zhaobin Guo, Cheng Chen, Xixiong Shi
Publikováno v:
Food Chemistry: X, Vol 24, Iss , Pp 101887- (2024)
Oula Tibetan sheep meat has rich nutritional value but relatively poor tenderness. Recently, apoptosis of muscle cells has gradually become a research hotspot for improving meat tenderness during postmortem aging. Smac can promote the decrease of IAP
Externí odkaz:
https://doaj.org/article/e5b11a8704e94129bd7bfa6ed407d2ae
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36176- (2024)
The dysfunction of pancreatic β-cells plays a pivotal role in the pathogenesis of type 2 diabetes mellitus (T2DM). Despite numerous studies demonstrating the anti-inflammatory and antioxidant properties of puerarin, the protective effects of puerari
Externí odkaz:
https://doaj.org/article/35feb072bf50495094166afd81ebe09b
Autor:
Jing Zhang, Wenjuan He, Dongmei Liu, Wenyu Zhang, Huan Qin, Song Zhang, Ailan Cheng, Qiang Li, Feilong Wang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundIt is unknown how cancer cells override apoptosis and maintain progression under nutrition-deprived conditions within the tumor microenvironment. Phosphoenolpyruvate carboxykinase (PEPCK or PCK) catalyzes the first rate-limiting reaction in
Externí odkaz:
https://doaj.org/article/f31b808a92744dab84d4368add103f44