Výsledky vyhledávání - "Mitochondrial Proteins/genetics/ metabolism"

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets

Autor: Blanca Rubi, Pierre Maechler, Marina Shamini Casimir, Francesca Frigerio, Gaelle Chaffard

Publikováno v: Biochemical Journal, Vol. 424, No 3 (2009) pp. 459-466

Transfer of reducing equivalents between cytosolic compartments and the mitochondrial matrix is mediated by NADH shuttles. Among these, the malate–aspartate shuttle has been proposed to play a major role in β-cells for the control of glucose-stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70541be245754d37c5b5e4fd5569f54e
https://archive-ouverte.unige.ch/unige:19728

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Nonshivering thermogenesis protects against defective calcium handling in muscle

Autor: Andrew M. Bellinger, Jan Aydin, Jan Nedergaard, Andrew R. Marks, Håkan Westerblad, Shi-Jin Zhang, Barbara Cannon, Joseph D. Bruton, Steven Reiken, Irina G. Shabalina, Nicolas Place

Publikováno v: FASEB Journal, Vol. 22, No 11 (2008) pp. 3919-3924

When acutely exposed to a cold environment, mammals shiver to generate heat. During prolonged cold exposure, shivering is replaced by adaptive adrenergic nonshivering thermogenesis with increased heat production in brown adipose tissue due to activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dbfdbc0ff91a2362409feb39ecbfc4
https://archive-ouverte.unige.ch/unige:19099

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Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species

Autor: Helene Perreten, Patrick A. Keller, Pedro Luis Herrera, Claes B. Wollheim, Asllan Gjinovci, Nathalie Davis-Lameloise, Nathalie Produit-Zengaffinen, Françoise Assimacopoulos-Jeannet, Patrick Muzzin, Dominique Becard

Publikováno v: Diabetologia, Vol. 50, No 1 (2007) pp. 84-93

AIMS/HYPOTHESIS: Levels of uncoupling protein-2 (UCP2) are regulated in the pancreatic beta cells and an increase in the protein level has been associated with mitochondrial uncoupling and alteration in glucose-stimulated insulin secretion. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25464da8da228b0d3ba3c3cfada59ece
https://pubmed.ncbi.nlm.nih.gov/17131143

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