The Identification of the Mitochondrial DNA Polymerase γ (Mip1) of the Entomopathogenic Fungus Metarhizium brunneum

Autor: Stylianos P. Varassas, Sotiris Amillis, Katherine M. Pappas, Vassili N. Kouvelis

Publikováno v: Microorganisms, Vol 12, Iss 6, p 1052 (2024)

Replication of the mitochondrial (mt) genome in filamentous fungi is under-studied, and knowledge is based mainly on data from yeasts and higher eukaryotes. In this study, the mitochondrial DNA polymerase γ (Mip1) of the entomopathogenic fungus Meta

Externí odkaz: https://doaj.org/article/c8742bbf38ae40bf930f634fc349bbc9

Mapping Adverse Outcome Pathways for Kidney Injury as a Basis for the Development of Mechanism-Based Animal-Sparing Approaches to Assessment of Nephrotoxicity

Autor: Angela Mally, Sebastian Jarzina

Publikováno v: Frontiers in Toxicology, Vol 4 (2022)

In line with recent OECD activities on the use of AOPs in developing Integrated Approaches to Testing and Assessment (IATAs), it is expected that systematic mapping of AOPs leading to systemic toxicity may provide a mechanistic framework for the deve

Externí odkaz: https://doaj.org/article/05865d91401541fd95d46eca7c68c700

Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Autor: Matthew J. Young

Publikováno v: Frontiers in Molecular Biosciences, Vol 4 (2017)

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome. Development of severe mitochondrial toxicity has been well documented in patien

Externí odkaz: https://doaj.org/article/b07023249ac14e3b9bb2fe79207fb8f8

Infectious stress triggers a POLG-related mitochondrial disease

Autor: Gaudó P, Emperador S, Garrido-Pérez N, Ruiz-Pesini E, Yubero-Siles D, Garcia-Cazorla A, Artuch-Iriberri R, Montoya C, Bayona-Bafaluy MP

Publikováno v: Neurogenetics
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

A 3-year-old girl presented with severe epilepsy in the context of Borrelia infection. After ceftriaxone/lidocaine administration, she showed secondarily generalized focal crises that led to neurological and motor sequelae. Genetic studies identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4922bf8532a7df50052016941ffa66ae
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16807

Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner

Autor: Geoffrey K. Herrmann, Nisha Jain Garg, William K. Russell, Y. Whitney Yin

Publikováno v: The Journal of Biological Chemistry

Mitochondrial DNA is located in organelle that house essential metabolic reactions and contains high reactive oxygen species. Therefore, mitochondrial DNA suffers more oxidative damage than its nuclear counterpart. Formation of a repair enzyme comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cb6da33523fa87f571f35606f0081c
https://doi.org/10.1016/j.jbc.2021.100309