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of 278
pro vyhledávání: '"Mitochondria-targeted antioxidants"'
Akademický článek
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Autor:
Konstantin G. Lyamzaev, He Huan, Alisa A. Panteleeva, Ruben A. Simonyan, Armine V. Avetisyan, Boris V. Chernyak
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 730 (2024)
Lipid peroxidation plays an important role in various pathologies and aging, at least partially mediated by ferroptosis. The role of mitochondrial lipid peroxidation during ferroptosis remains poorly understood. We show that supplementation of exogen
Externí odkaz:
https://doaj.org/article/ad32d22f44b64d288a76ed595cc66194
Autor:
Pavel A. Nazarov, Vladislav S. Maximov, Alexander M. Firsov, Marina V. Karakozova, Veronika Panfilova, Elena A. Kotova, Maxim V. Skulachev, Yuri N. Antonenko
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6137 (2024)
Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of other active substances to mitochondria and bacteria. Their most studied representatives are
Externí odkaz:
https://doaj.org/article/60d327de2eb64c31baf99c99657766e1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Oxidative stress nearly always accompanies all stages of cancer development. At the early stages, antioxidants may help to reduce reactive oxygen species (ROS) production and exhibit anticarcinogenic effects. In the later stages, ROS involvement beco
Externí odkaz:
https://doaj.org/article/b953ffddc57740808c43ce1f21776272
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 688 (2023)
The penetration of substances through the bacterial cell envelope is a complex and underinvestigated process. Mitochondria-targeted antioxidant and antibiotic SkQ1 (10-(plastoquinonyl)decyltriphenylphosphonium) is an excellent model for studying the
Externí odkaz:
https://doaj.org/article/64c67f6bb0054bfaaf24e056c36b62c6
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 794 (2023)
Mitochondrial ROS (mitoROS) control many reactions in cells. Biological effects of mitoROS in vivo can be investigated by modulation via mitochondria-targeted antioxidants (mtAOX, mitoTEMPO). The aim of this study was to determine how mitoROS influen
Externí odkaz:
https://doaj.org/article/1d3e90093f834a52b5670e5a012137a3
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 898 (2023)
Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as d
Externí odkaz:
https://doaj.org/article/cfab9b26ae2943a28cb7e98e21f2779d
Autor:
Konstantin G. Lyamzaev, Alisa A. Panteleeva, Ruben A. Simonyan, Armine V. Avetisyan, Boris V. Chernyak
Publikováno v:
Cells, Vol 12, Iss 4, p 611 (2023)
Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine (an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted antioxidants SkQ1 and MitoTEMPO. These effects correlate with the preve
Externí odkaz:
https://doaj.org/article/82e0faa0c5e44d039164f4c64776998d
Autor:
Carlos Fernandes, Fernando Cagide, Jorge Simões, Carlos Pita, Eurico Pereira, Afonso J. C. Videira, Pedro Soares, José F. S. Duarte, António M. S. Santos, Paulo J. Oliveira, Fernanda Borges, Filomena S. G. Silva
Publikováno v:
Molecules, Vol 27, Iss 19, p 6183 (2022)
Targeting antioxidants to mitochondria is considered a promising strategy to prevent cellular senescence and skin ageing. In this study, we investigate whether four hydroxybenzoic acid-based mitochondria-targeted antioxidants (MitoBENs, MB1-4) could
Externí odkaz:
https://doaj.org/article/ab50c62d3d9f489b8379c3acc898eedd