Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mitochondria/*drug effects/metabolism"'
Autor:
Johan Auwerx, Hongbo Zhang, Anthony A. Sauve, Xu Wang, Casey J. Wegner, Sung I. Koo, Karim Gariani, Young-Ki Park, Dongryeol Ryu, Carlos Cantó, Alessandra Piersigilli, Alessia Perino, Chai Siah Ku, Vera Lemos, Norman Moullan, Yue Yang, Keir J. Menzies, Kristina Schoonjans, Tho X. Pham, Bohkyung Kim, Ji-Young Lee, Eduardo R. Ropelle, Anna Fomitchova
Publikováno v:
Hepatology (Baltimore, Md.)
Hepatology, Vol. 63, No 4 (2016) pp. 1190-204
Hepatology, Vol. 63, No 4 (2016) pp. 1190-204
With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease in Western countries and its worldwide prevalence continues to increase along with the growing obesity epidemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4fc74a3081bb02f9444ac926f31591
https://doi.org/10.1002/hep.28245
https://doi.org/10.1002/hep.28245
Autor:
Marie-Jeanne Richard, Laurent Argaud, Sandrine Lablanche, Cécile Cottet-Rousselle, Thierry Berney, Pierre-Yves Benhamou, Camille Laporte, Eric Fontaine, Frédéric Lamarche
Publikováno v:
Biochimica et Biophysica Acta, Vol. 1847, No 6-7 (2015) pp. 629-639
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2015, 1847 (6-7), pp.629-39. ⟨10.1016/j.bbabio.2015.04.002⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2015, 1847 (6-7), pp.629-39. ⟨10.1016/j.bbabio.2015.04.002⟩
International audience; Deficit in oxygen and energetic substrates delivery is a key factor in islet loss during islet transplantation. Permeability transition pore (PTP) is a mitochondrial channel involved in cell death. We have studied the respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284c70d7aa72f9100d0259f1d6147062
https://doi.org/10.1016/j.bbabio.2015.04.002
https://doi.org/10.1016/j.bbabio.2015.04.002
Autor:
Hubert Vidal, Jennifer Rieusset, Nadia Bendridi, Guillaume Vial, Jean-Paul Pais de Barros, Cécile Acquaviva, Eric Fontaine, Annie Durand, Sophie Hallakou-Bozec, Sébastien Bolze, Anne-Marie Madec, Marie-Agnès Chauvin, Nathalie Bernoud-Hubac, Emmanuelle Meugnier
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2254-2264
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2254-64. ⟨10.2337/db14-1220⟩
HAL
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2254-2264
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2254-64. ⟨10.2337/db14-1220⟩
HAL
International audience; Imeglimin is the first in a new class of oral glucose-lowering agents currently in phase 2b development. Although imeglimin improves insulin sensitivity in humans, the molecular mechanisms are unknown. This study used a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68f57dbcebbd89d150a6eb08da569e
https://hal.archives-ouvertes.fr/hal-01981987
https://hal.archives-ouvertes.fr/hal-01981987
Autor:
Victor Pallarès, Santiago Garcia-Vallvé, Anna Ardévol, M. José Motilva, M. Teresa Blay, Pierre Maechler, Anna Castell-Auví, Lídia Cedó, Gerard Pujadas, Montserrat Pinent
Publikováno v:
Journal of Nutritional Biochemistry, Vol. 23, No 12 (2012) pp. 1565-72
The Journal of nutritional biochemistry
The Journal of nutritional biochemistry
Previous studies from our research group have suggested that procyanidins modify glycemia and insulinemia. The aim of this work was to evaluate the effects of procyanidins on β-cell functionality in a nonpathological system. Four groups of healthy r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a66716f5a5050e7df8d75cbb64b997f
https://doi.org/10.1016/j.jnutbio.2011.10.010
https://doi.org/10.1016/j.jnutbio.2011.10.010
Autor:
Valérie Desquiret, Arnaud Chevrollier, Virginie Guillet, Patrizia Amati-Bonneau, Claire Angebault, Naïg Gueguen, Romain Cartoni, Vincent Procaccio, Jean-Claude Martinou, Dominique Bonneau, Pascal Reynier
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25 (5), pp.1618-27. ⟨10.1096/fj.10-173609⟩
FASEB Journal, Vol. 25, No 5 (2011) pp. 1618-27
FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25 (5), pp.1618-27. ⟨10.1096/fj.10-173609⟩
FASEB Journal, Vol. 25, No 5 (2011) pp. 1618-27
International audience; Charcot-Marie-Tooth disease type 2A (CMT2A) is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene (MFN2), which encodes a mitochondrial outer membrane protein that promotes m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b84d33ebc371477a05bbb3f73ab233f
https://doi.org/10.1096/fj.10-173609
https://doi.org/10.1096/fj.10-173609
Publikováno v:
Cell Death and Differentiation, Vol. 17, No 11 (2010) pp. 1785-1794
Cell death and differentiation
Cell death and differentiation
During apoptosis, mitochondria lose their membrane potential and undergo fragmentation around the time of release of cytochrome c. Apoptotic fission is at least in part sustained by the translocation of dynamin-related protein 1 (Drp1), normally loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a072b6d880d9593c4706c2219f9e606
https://doi.org/10.1038/cdd.2010.61
https://doi.org/10.1038/cdd.2010.61
Autor:
Raffaele Baffa, Gerhard Wiche, Kai Stefan Dimmer, Luca Scorrano, Vassiliki Anesti, Dan Liu, Aswin Pyakurel, Deborah Naon, Cristina Cerqua
Publikováno v:
EMBO reports
EMBO Reports, Vol. 11, No 11 (2010) pp. 854-860
EMBO Reports, Vol. 11, No 11 (2010) pp. 854-860
Trichoplein/mitostatin (TpMs) is a keratin-binding protein that partly colocalizes with mitochondria and is often downregulated in epithelial cancers, but its function remains unclear. In this study, we report that TpMs regulates the tethering betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5c6251ef17ba0a14ead9a2ebc27208
Autor:
Françoise de Longueville, Andrée Houbion, Thierry Arnould, Aurélia De Pauw, Silvia Tejerina, Patricia Renard, Martine Raes, Sébastien Vankoningsloo
Publikováno v:
Journal of Cell Science, Vol. 122, no. 1, p. 145-55 (2009)
Impairment of mitochondrial activity affects lipid-metabolizing tissues and mild mitochondrial uncoupling has been proposed as a possible strategy to fight obesity and associated diseases. In this report, we characterized the 3T3-L1-adipocyte ;de-dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b9870e0b834418cd705038bdc74e24
https://doi.org/10.1242/jcs.027508
https://doi.org/10.1242/jcs.027508
Autor:
Nathalie C Girardin, Maud Frieden, Nicolas Demaurex, Wolfgang F. Graier, Roland Malli, Hélène Jousset
Publikováno v:
Cell Calcium, Vol. 43, No 1 (2008) pp. 83-94
Ca(2+) entry in endothelial cells is a key signaling event as it prolongs the Ca(2+) signal activated by a receptor agonist, and thus allows an adequate production of a variety of compounds. The possible routes that lead to Ca(2+) entry in non-excita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a95f287a6e57a87779620807b28bbe8
https://doi.org/10.1016/j.ceca.2007.04.006
https://doi.org/10.1016/j.ceca.2007.04.006
Autor:
Thomas W.H. Kay, Lut Overbergh, Dieter Rondas, Chantal Mathieu, Stacey Fynch, Jibran Ja Wali, Helen E. Thomas, Andreas Strasser, Mark D. McKenzie, Esteban Nicolas Gurzov, Yuxing Zhao, Shizuo Akira, Lorraine Elkerbout
Publikováno v:
Cell death & disease, 5
Cell Death & Disease
Cell Death & Disease
Apoptosis of pancreatic beta cells is a feature of type 2 diabetes and its prevention may have therapeutic benefit. High glucose concentrations induce apoptosis of islet cells, and this requires the proapoptotic Bcl-2 homology domain 3 (BH3)-only pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de89d9a548d7de59388b8a4a9e4baac
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260216
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260216