Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mitocôndrias Cardiacas"'
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Trimetazidine is an anti-ischemic drug whose cytoprotective mechanisms are not yet fully understood (but until now mainly related to the trimetazidine-induced "metabolic shift" from lipid [beta]-oxidation to glucose aerobic oxidation). We studied the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34edcdd990330196f4955cd09c6f94c0
https://doi.org/10.1016/j.ejphar.2004.09.003
https://doi.org/10.1016/j.ejphar.2004.09.003
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The effect of valsartan, an angiotensin II-type I receptor blocker, on the mitochondrial function, was studied using an ex vivo animal model (hearts from Wistar rats), perfused in a Langendorff system and then submitted to global acute ischemia. Para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1032ba6dcbfdb12a1ef7fb26f5d9fbcb
https://hdl.handle.net/10400.4/312
https://hdl.handle.net/10400.4/312
Autor:
Carreira, R, Duarte, AI, Monteiro, P, Santos, MS, Rego, AC, Oliveira, CR, Gonçalves, L, Providência, LA
Ischemia negatively affects mitochondrial function by inducing the mitochondrial permeability transition (MPT). The MPT is triggered by oxidative stress, which occurs in mitochondria during ischemia as a result of diminished antioxidant defenses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1504::eb96576712a981d0465e9c9bd11c43e4
https://hdl.handle.net/10400.4/342
https://hdl.handle.net/10400.4/342
Recent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations. This has clearly highlighted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1504::9ae501c22e9309ebd9fd9b696995659b
https://hdl.handle.net/10400.4/926
https://hdl.handle.net/10400.4/926
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cardiac mitochondria may become dysfunctional during ischaemia, thus compromising cardiomyocyte function. Carvedilol is an [alpha]1/[beta]-adrenoceptor antagonist with antioxidant, neuroprotective, cardioprotective and vascularprotective properties,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790d770404841df8aeb065537d743ba1
https://hdl.handle.net/10316/4796
https://hdl.handle.net/10316/4796
O piruvato é um substracto energético com reconhecidas propriedades cardioprotectoras. Sabe-se hoje que isso se deve não só à sua actividade antioxidante, mas também ao facto de reduzir a acidose intracelular, modular a cinética intracitosóli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8c7812ea178262251845bef65141959e
https://hdl.handle.net/10400.4/341
https://hdl.handle.net/10400.4/341
Publikováno v:
CIÊNCIAVITAE
Objectivo: Os efeitos cardioprotectores do carvedilol (CV) poderão ser explicados, em parte, por interacções ao nível da mitocôndria cardíaca. O objectivo deste trabalho visou o estudo do efeito protector do CV em mitocôndrias cardíacas duran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::39d5811e61ad0fc716e201c70ebef0b5
https://hdl.handle.net/10400.4/340
https://hdl.handle.net/10400.4/340
Autor:
Oliveira, P. J., Esteves, T., Anabela Rolo, Monteiro, P., Gonçalves, L., Palmeira, C. M., Moreno, A. J.
Publikováno v:
CIÊNCIAVITAE
Objectivos: A transição de permeabilidade mitocondrial (TPM) é um evento associado a estresse oxidativo severo (por exemplo, durante isquémia e reperfusão do miocárdio) e acumulação excessiva de cálcio mitocondrial, podendo mesmo levar a mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7e1cfde7e574ea69ccb4cb859040be77
http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS
Autor:
Oliveira, P. J., Rolo, A. P., Sardão, V. A., Monteiro, P., Gonçalves, L., Providência, L. A., Palmeira, C. M., António Moreno
Publikováno v:
Scopus-Elsevier
CIÊNCIAVITAE
CIÊNCIAVITAE
BACKGROUND: Carvedilol is a neurohormonal antagonist of multiple action which is used in clinical practice for the treatment of congestive heart failure, mild to moderate hypertension and myocardial infarction. Previous results from our group have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::119b00c186cb23ad0471ebd143bc67ed
http://www.scopus.com/inward/record.url?eid=2-s2.0-10644236410&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-10644236410&partnerID=MN8TOARS