Výsledky vyhledávání

Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients

Autor: Mikio Shoji, Takeshi Hayashi, Isao Nagano, Hisashi Narai, Koji Abe, Mito Shiote, Tetsuro Murakami, Tetsuya Nagata

Publikováno v: Neurological Research. 29:772-776

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with progressive cell death of upper and lower motor neurons. In this study, we measured monocyte chemotactic protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) levels in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06002e2aded3675b451bac81b393c5c
https://doi.org/10.1179/016164107x229795

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Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene

Autor: Mito Shiote, Koji Abe, Isao Nagano, Tetsuro Murakami, Tomoko Kurata, Hisashi Narai, Makiko Nagai, Yasuyuki Ohta, Mikio Shoji, Tetsuya Nagata

Publikováno v: Journal of Neuroscience Research. 84:980-992

We investigated three steps of neural precursor cell activation--proliferation, migration, and differentiation--in amyotrophic lateral sclerosis spinal cord treated with intrathecal infusion of epidermal growth factor (EGF) and fibroblast growth fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6fb7fc62db11aee541364e8bb25f0c
https://doi.org/10.1002/jnr.21017

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Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis

Autor: Mikio Shoji, Etsuro Matsubara, Mito Shiote, Masataka Yokoyama, Isao Nagano, Y. Hamakawa, Hiroshi Kamada, Tetsuro Murakami, Kiyoshi Morita, Koji Abe

Publikováno v: Neurological Research. 27:768-772

There is currently no effective pharmacological treatment for amyotrophic lateral sclerosis (ALS). In a transgenic mouse model of ALS, intrathecal infusion of insulin-like growth factor (IGF)-1 showed a promising increase in survival. We performed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c616a4de173c4343178f2c0330a559
https://doi.org/10.1179/016164105x39860

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Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis

Autor: Mito Shiote, Isao Nagano, Hristelina Ilieva, Masataka Yokoyama, Mikio Shoji, Koji Abe, Tetsuro Murakami

Publikováno v: Journal of the Neurological Sciences. 235:61-68

Insulin-like growth factor (IGF)-1 has been shown to have a protective effect on motor neurons both in vitro and in vivo, but has limited efficacy in patients with amyotrophic lateral sclerosis (ALS) when given subcutaneously. To examine the possible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b752b78888a00dff495b2697b8729a
https://doi.org/10.1016/j.jns.2005.04.011

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Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis

Autor: Tetsuro Murakami, Isao Nagano, Yoshiko Yanagisawa, Shinji Hadano, Yasuhiro Manabe, Joh-E Ikeda, Koji Abe, Mito Shiote

Publikováno v: Neurological Research. 25:505-509

ALS2 is an autosomal recessive form of amyotrophic lateral sclerosis (AR-ALS) with juvenile onset, and has been mostly found in North African and Middle Eastern countries. Deletion mutations in the coding exons of a new gene ALS2, encoding a protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1187ac632d45a65008165ff220d30959
https://doi.org/10.1179/016164103101201733

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Hypoxic induction of vascular endothelial growth factor is impaired in the spinal cord of the mice with mutant human SOD1 gene

Autor: Koji Abe, Tetsuro Murakami, Isao Nagano, Yasuhiro Manabe, Hristelina Ilieva, Mito Shiote, Mikio Shoji

Publikováno v: International Congress Series. 1252:57-63

We examined the induction of vascular endothelial growth factor (VEGF) in the G93A superoxide dismutase (SOD)1-mutant mice exposed to systemic hypoxia. Generally, baseline expression of VEGF in the spinal cord was increased in the SOD1-mutant mice co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6f999c398233e6b45d9fb932c3c83e7
https://doi.org/10.1016/s0531-5131(03)00098-0

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Alteration in survival signal induction by transient hypoxia in mice expressing mutant human SOD1 protein

Autor: Isao Nagano, Mito Shiote, Mikio Shoji, Hristelina Ilieva, Tetsuro Murakami, Koji Abe

Publikováno v: International Congress Series. 1252:73-81

Expression of survival phosphorylated serine/threonine kinase AKT (p-AKT) and phosphorylated extracellular signal-regulated kinase (p-ERK) signals was examined by immunohistochemistry and Western blotting in the lumbar spinal cord of 12-week-old mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6aedaa845dcff7f726e4f9c59aeb3cf
https://doi.org/10.1016/s0531-5131(03)00016-5

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Early decrease of survival signal protein and DNA repair enzyme in spinal motor neuron of presymptomatic transgenic mice with a mutant SOD1 gene

Autor: Takeshi Hayashi, Mito Shiote, Hristelina Ilieva, Isao Nagano, Tetsuro Murakami, Koji Abe, Mikio Shoji

Publikováno v: International Congress Series. 1252:65-71

We examined expressions of phosphatidylinositol 3-kinase (PI3-K), Akt and redox factor-1 protein (Ref-1) in the spinal cord of transgenic mice with G93A mutant superoxide dismutase (SOD1) (Tg), a valuable model of human amyotrophic lateral sclerosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bd351dbe9fa0d79ad3f6d3d5d5e0d68
https://doi.org/10.1016/s0531-5131(03)00069-4

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Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis

Autor: Isao Nagano, Tetsuro Murakami, M.S.A. Gazi, Koji Abe, Yasuhiro Manabe, Mito Shiote, Mikio Shoji, H. Kitagawa

Publikováno v: Neurological Research. 25:195-200

Effects of glial cell line-derived neurotrophic factor (GDNF) were studied in transgenic (Tg) mice model for amyotrophic lateral sclerosis. GDNF protein or vehicle was injected three times a week from 35 weeks of age into the right gastrocnemius musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4262b16a1afba394a8907ad551cc6958
https://doi.org/10.1179/016164103101201193

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Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1

Autor: Yasuhiro Manabe, Koji Abe, Mikio Shoji, Takeshi Hayashi, Hitoshi Warita, Isao Nagano, Mito Shiote, Tetsuro Murakami, Yoshihiko Shiro

Publikováno v: Neurological Research. 24:577-581

The expressions of glutamate transporter proteins were immunocytochemically examined in the spinal cord of transgenic mice harboring a Gly93 → Ala (G93A) mutant human SOD1 gene. Astroglial EAAT2 protein level was preserved in the ventral horn even

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99102fe8759bfc2725ea78be9a356552
https://doi.org/10.1179/016164102101200384

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