Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mithun Raje"'
Autor:
Yinan Wang, Chuanhe Yang, Michelle M. Sims, Joshua R. Sacher, Mithun Raje, Hemantkumar Deokar, Peibin Yue, James Turkson, John K. Buolamwini, Lawrence M. Pfeffer
Publikováno v:
Cancer Letters. 533:215614
Glioblastoma (GBM) is a highly aggressive cancer with a dismal prognosis. Constitutively active STAT3 has a causal role in GBM progression and is associated with poor patient survival. We rationally designed a novel small molecule, SS-4, by computati
Autor:
Jay Chauhan, Gregory E.A. Vickers, Paul T. Wilder, Mithun Raje, Steven Fletcher, Nathan G. Bowen, Daniel Van Eker, Ian C. Fenimore, Ellis Whiting, Samuel J. Hughes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:523-528
Abstarct Inspired by a rhodanine-based dual inhibitor of Bcl-xL and Mcl-1, a focused library of analogues was prepared wherein the rhodanine core was replaced with a less promiscuous thiazolidine-2,4-dione scaffold. Compounds were initially evaluated
Autor:
Eishi Ashihara, Keisuke Nishioka, Takashi Kida, Aiko Hirano, Kazuki Fujioka, Tomoya Sagawa, Jeffrey Strovel, Aki Sakashita, Mithun Raje, Akiko Kasahara, Masataka Kohno, Takuya Inoue, Yutaka Kawahito, Hidetake Nagahara, Makoto Wada, Shunya Kaneshita, Makoto Yoshioka, Steven Fletcher
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 70:102057
Pulmonary fibrosis is a progressive disease with poor prognosis and limited therapeutic options. In this study, we evaluated the potential therapeutic effects of CG223, a novel inhibitor of bromodomain and extra-terminal motif (BET) proteins, on pulm
Autor:
Veronica Soloveva, Katherine L. Seley-Radtke, Mike Flint, Mary K. Yates, Mithun Raje, Christina F. Spiropoulou, Payel Chatterjee, Sina Bavari
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most
Autor:
Lijia Chen, Jeremy L. Yap, Brandon Drennen, Mithun Raje, Paul T. Wilder, Maryanna E. Lanning, Steven Fletcher, H. Bailey, Michael C. Cavalier
Publikováno v:
Organic & Biomolecular Chemistry. 13:8642-8646
Mimicry of two faces of an α-helix might yield more potent and more selective inhibitors of dysregulated, helix-mediated protein–protein interactions (PPI). Herein, we demonstrate that a 2,6,9-tri-substituted purine is capable of disrupting the Mc
Publikováno v:
European Journal of Pharmacology. 722:26-37
Nausea and vomiting are major side effects of chemotherapy and one key reason for non-compliance with cancer treatment. The introduction of 5-HT3 receptor antagonists in the 1990s was a major advance in the prevention of acute emesis, and highlighted
Autor:
Yugesh Kharel, Ming Gao, Amanda M. Gellett, Mithun Raje, Webster L. Santos, Kevin R. Lynch, Jose L. Tomsig
Publikováno v:
Biochemical Journal. 447:149-157
S1P (sphingosine 1-phosphate) is a pleiotropic lipid mediator involved in numerous cellular and physiological functions. Of note among these are cell survival and migration, as well as lymphocyte trafficking. S1P, which exerts its effects via five GP
Autor:
Jay Chauhan, Shen En Chen, Christian Lee, Eric J. Sundberg, Mithun Raje, Jeffrey J. DeStefano, Aurash Naser-Tavakolian, Katherine J. Fenstermacher, Emori Williams, Tali H. Reingewertz, Ernesto Freire, Steven Fletcher, Rosene Salmo
Small-molecule mimetics of the β-hairpin flap of HIV-1 protease (HIV-1 PR) were designed based on a 1,4-benzodiazepine scaffold as a strategy to interfere with the flap-flap protein-protein interaction, which functions as a gated mechanism to contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf8e7a5263b608d473594ead1aa22ae
https://europepmc.org/articles/PMC4661106/
https://europepmc.org/articles/PMC4661106/
Autor:
Yugesh Kharel, Mithun Raje, Webster L. Santos, Ming Gao, Kevin R. Lynch, Jose L. Tomsig, Emily A. Morris, Neeraj N. Patwardhan
Publikováno v:
Journal of medicinal chemistry. 58(4)
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that acts as a ligand for five G-protein coupled receptors (S1P1-5) whose downstream effects are implicated in a variety of important pathologies including sickle cell disease, cancer,
Autor:
Takashi Tsukamoto, Dana Ferraris, Bridget Duvall, Niyada Hin, Mithun Raje, Barbara S. Slusher, James F. Berry, Ajit G. Thomas, Jesse Alt, Camilo Rojas
A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit d -amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24c91b4c533d571d1736e7a775c9adb
https://europepmc.org/articles/PMC3678123/
https://europepmc.org/articles/PMC3678123/