Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mithun Khattar"'
Autor:
Gabriel Helmlinger, Rachel Burga, Stanley Tam, Mithun Khattar, Scott Lajoie, Kyle Pedro, Colleen Foley, Alonso Villasmil Ocando, Jack Tremblay, Benjamin Primack, Meghan Langley, Dan Thornton, Emily Brideau, Theresa Ross, Gwen Wilmes, Sunandan Saha, Jeremy Tchaicha, Dhruv Sethi, Michelle Ols, Gary Vanasse, Shyam Subramanian, Jan ter Meulen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/96bcf551331a468aa219481d0e648459
Autor:
Mithun Khattar, Caitlin E Baum, Paul Schroder, Joshua D Breidenbach, Steven T Haller, Wenhao Chen, Stanislaw Stepkowski
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225624 (2019)
IL-21 is the most recently discovered common gamma-chain cytokine that promotes persistent T-cell responses in chronic infections, autoimmunity and cancer. However, the therapeutic potential of inhibiting the IL-21-BATF signaling axis, particularly i
Externí odkaz:
https://doaj.org/article/1af312a4034a401482b9ea7ee0f3c3c9
Autor:
Mithun Khattar, Yoshihiro Miyahara, Paul M Schroder, Aini Xie, Wenhao Chen, Stanislaw M Stepkowski
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85882 (2014)
Optimal T cell activation and expansion require binding of the common gamma-chain (γc) cytokine Interleukin-2 (IL-2) to its cognate receptor that in turn engages a γc/Janus tyrosine kinase (Jak)3 signaling pathway. Because of its restricted express
Externí odkaz:
https://doaj.org/article/dfc770baab604d759e9b2c8410d641e7
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69397 (2013)
T cells play a major role in allograft rejection, which occurs after T cell activation by the engagement of several functional molecules to form an immune synapse with alloantigen presenting cells. In this study, the immune synapse was targeted using
Externí odkaz:
https://doaj.org/article/a601bf2d396c429eb0821e0e1952dd50
Autor:
Mithun Khattar, Karuppiah Kannan
Publikováno v:
Animal Models for the Development of Cancer Immunotherapy. :1-10
Autor:
Rachel Burga, Zheng Ao, Arman Aksoy, Scott Lajoie, Kyle Pedro, Jack Tremblay, Gauri Kulkarni, Alonso Villasmil Ocando, Benjamin Primack, Meghan Langley, Theresa Ross, Jeremy Tchaicha, Michelle Ols, Jan ter Meulen, Mithun Khattar
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Carmela Passaro, Balazs Koscso, Sean Smith, Violet Young, Theresa Ross, Benjamin Primack, Natasha Ly, Patricia Timpug, Shabnam Davoodi, Rachel Burga, Gauri Kulkarni, Scott Lajoie, Meghan Langley, Nirzari Shah, Dexue Sun, Dan Jun Li, Raina Duan, Arman Aksoy, Mithun Khattar, Jeremy Tchaicha, Dhruv Sethi, Jan ter Meulen, Michelle Ols
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Sunandan Saha, Rachel A. Burga, Meghan Langley, Michelle Ols, Jack Tremblay, Stanley Tam, Jeremy Hatem Tchaicha, Benjamin Primack, Colleen Foley, Gabriel Helmlinger, Theresa Ross, Sethi Dhruv Kam, Emily Brideau, Shyam Subramanian, Alonso Villasmil Ocando, Kyle Pedro, Mithun Khattar, Scott Lajoie, Gary Vanasse, Dan Thornton, Jan ter Meulen, Gwen Wilmes
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAdoptive cell therapy with tumor-infiltrating lymphocytes (TILs) has demonstrated tremendous promise in clinical trials for patients with solid or metastatic tumors.1 However, current TIL therapy requires systemic administration of IL-2 to
Autor:
Keli Song, James Minissale, Richard A. Klinghoffer, James Garnsey, Katherine Galvin, Kristina Xega, Sai M Pulukuri, James M. Gavin, Xiaofeng Yang, Pooja Shah, Gary Shapiro, Cong Li, Vaishali Shinde, Eric S. Lightcap, Dennis Huszar, Zhen Lu, Stephen Grossman, Erik Koenig, Pengfei Yu, Steve Langston, Hisashi Imaichi, Serge Y. Fuchs, Mithun Khattar, Beryl A. Hatton, Yu Fu, Hongru Zhang, Dylan England, Michael Milhollen, Jessica Riceberg, Xingyue He
Publikováno v:
Sci Transl Med
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small molecule inhibitor of SUMOylation, pharmacologi
Autor:
Jeremy H. Tchaicha, Scott Lajoie, Rachel Burga, Theresa Ross, Benjamin Primack, Meghan Langley, Violet Young, Alonso Villasmil Ocando, Kyle Pedro, Jack Tremblay, Gauri Kulkarni, Mithun Khattar, Dhruv Sethi, Michelle Ols, Gabriel Helmlinger, Gary Vanasse, Shyam Subramanian, Jan ter Meulen
Publikováno v:
Cancer Research. 82:LB212-LB212
Standard tumor-infiltrating lymphocyte (TIL) therapy requires IL-2 administration to support TIL expansion and survival, but this cytokine is associated with T cell exhaustion and can result in severe toxicities that limit patient eligibility (1). To