Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mithun C. Mahawaththa"'
Autor:
Joe A. Kaczmarski, Mithun C. Mahawaththa, Akiva Feintuch, Ben E. Clifton, Luke A. Adams, Daniella Goldfarb, Gottfried Otting, Colin J. Jackson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cyclohexadienyl dehydratase (CDT) evolved from a cationic amino acid binding protein ancestor without enzymatic activity (AncCDT-1) via a series of intermediates. Here, the authors combine EPR, X-ray crystallography and MD simulations to study the st
Externí odkaz:
https://doaj.org/article/c19f20f6641e4d50a18da243f7703954
Autor:
Kasuni B. Ekanayake, Mithun C. Mahawaththa, Haocheng Qianzhu, Elwy H. Abdelkader, Josemon George, Sven Ullrich, Rhys B. Murphy, Sarah E. Fry, Jason Johansen-Leete, Richard J. Payne, Christoph Nitsche, Thomas Huber, Gottfried Otting
Publikováno v:
Journal of Medicinal Chemistry. 66:5289-5304
Site-selective generation of lanthanoid binding sites on proteins using 4-fluoro-2,6-dicyanopyridine
Autor:
Sreelakshmi Mekkattu Tharayil, Mithun C. Mahawaththa, Akiva Feintuch, Ansis Maleckis, Sven Ullrich, Richard Morewood, Michael J. Maxwell, Thomas Huber, Christoph Nitsche, Daniella Goldfarb, Gottfried Otting
The paramagnetism of a lanthanoid tag site-specifically installed on a protein provides a rich source of structural information accessible by nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy. Here we report a la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc30d1da696e42187a03bfa2a9dce7d2
https://mr.copernicus.org/articles/3/169/2022/
https://mr.copernicus.org/articles/3/169/2022/
Autor:
Sreelakshmi Mekkattu Tharayil, Mithun C. Mahawaththa, Akiva Feintuch, Ansis Maleckis, Sven Ullrich, Richard Morewood, Thomas Huber, Christoph Nitsche, Daniella Goldfarb, Gottfried Otting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f197b06959796ad7f203cd58b8a7f787
https://doi.org/10.5194/mr-2022-11-supplement
https://doi.org/10.5194/mr-2022-11-supplement
Autor:
Jason Johansen-Leete, Sven Ullrich, Sarah E. Fry, Rebecca Frkic, Max J. Bedding, Anupriya Aggarwal, Anneliese S. Ashhurst, Kasuni B. Ekanayake, Mithun C. Mahawaththa, Vishnu M. Sasi, Stephanie Luedtke, Daniel J. Ford, Anthony J. O'Donoghue, Toby Passioura, Mark Larance, Gottfried Otting, Stuart Turville, Colin J. Jackson, Christoph Nitsche, Richard J. Payne
Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. Here we report the use of the Random n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb19951e5ab5d8ede201d6868c3b957
https://hdl.handle.net/2123/28987
https://hdl.handle.net/2123/28987
Autor:
Gottfried Otting, Adarshi P. Welegedara, Haocheng Qianzhu, Mithun C. Mahawaththa, Nicholas E. Dixon, Amy E. McGrath, Thomas Huber, Holly Williamson
Publikováno v:
Journal of the American Chemical Society. 142:17277-17281
SF5Phe, para-pentafluorosulfanyl phenylalanine, is an unnatural amino acid with extreme physicochemical properties, which is stable in physiological conditions. Here we present newly developed aminoacyl-tRNA synthetases that enable genetic encoding o
Autor:
Hiroaki Suga, Paul Varava, Toby Passioura, Christian D. Klein, Mithun C. Mahawaththa, Gottfried Otting, Christoph Nitsche, Mila M. Leuthold
Publikováno v:
ACS Medicinal Chemistry Letters. 10:168-174
[Image: see text] The Zika virus presents a major public health concern due to severe fetal neurological disorders associated with infections in pregnant women. In addition to vaccine development, the discovery of selective antiviral drugs is essenti
Autor:
Rebecca L. Frkic, Sarah E. Fry, Anneliese S. Ashhurst, Colin J. Jackson, Mithun C. Mahawaththa, Kasuni B Ekanayake, Anupriya Aggarwal, Gottfried Otting, Toby Passioura, Stuart Turville, Christoph Nitsche, Mark Larance, Vishnu M. Sasi, Sven Ullrich, Max J. Bedding, Richard J. Payne, Jason Johansen-Leete
Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. Here we report the use of the Random n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11c7e55951f3e1a3dfdaa05222defab
https://hdl.handle.net/2123/26145
https://hdl.handle.net/2123/26145
Autor:
Iresha D. Herath, Yi Jiun Tan, Daniella Goldfarb, Thomas Huber, Adarshi P. Welegedara, Angeliki Giannoulis, Mithun C. Mahawaththa, Gottfried Otting, Ansis Maleckis, Ruchira Bandara
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(8)
The selenol group of selenocysteine is much more nucleophilic than the thiol group of cysteine. Selenocysteine residues in proteins thus offer reactive points for rapid post-translational modification. Herein, we show that selenoproteins can be expre
Autor:
Choy-Theng Loh, Mithun C. Mahawaththa, Ibidolapo Adekoya, Sreelakshmi Mekkattu Tharayil, Gottfried Otting
Pseudocontact shifts (PCS) generated by paramagnetic lanthanide ions provide valuable long-range structural information in NMR spectroscopic analyses of biological macromolecules such as proteins, but labelling proteins site-specifically with a singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd6a6bf1afba5f100d498ab73ead9eb
https://mr.copernicus.org/preprints/mr-2020-26/
https://mr.copernicus.org/preprints/mr-2020-26/