Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mithula Sivasaravanaparan"'
Autor:
Louise Ørum Olesen, Mithula Sivasaravanaparan, Maurizio Severino, Alicia A. Babcock, Elena V. Bouzinova, Mark J. West, Ove Wiborg, Bente Finsen
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 50-60 (2017)
Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transge
Externí odkaz:
https://doaj.org/article/3f5e20cd7c5a44309461c26328dc1783
Autor:
Louise Ørum Olesen, Elena V Bouzinova, Maurizio Severino, Mithula Sivasaravanaparan, Jørgen Bo Hasselstrøm, Bente Finsen, Ove Wiborg
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165144 (2016)
Alzheimer's disease (AD) is a devastating illness characterized by a progressive loss of cognitive, social, and emotional functions, including memory impairments and more global cognitive deficits. Clinical-epidemiological evidence suggests that neur
Externí odkaz:
https://doaj.org/article/cf0ad03ffb58448e9689516cc0a5e904
Autor:
Kate Lykke Lambertsen, Jan Bert Gramsbergen, Mithula Sivasaravanaparan, Nicholas Ditzel, Linda Maria Sevelsted-Møller, Aida Oliván-Viguera, Maj Rabjerg, Heike Wulff, Ralf Köhler
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47744 (2012)
The calmodulin/calcium-activated K(+) channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. However, our knowledge about its contribution to neurological functions and behavio
Externí odkaz:
https://doaj.org/article/0fad14b82d2e47bda172ff3266e8e9bb
Autor:
Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jørgen Hasselstrøm, Athanasios Metaxas, Ove Wiborg, Bente Finsen
Publikováno v:
Sivasaravanaparan, M, Olesen, L Ø, Severino, M, von Linstow, M C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019
Sivasaravanaparan, M, Olesen, L Ø, Severino, M, Von Linstow, C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APP SWE/PS1 ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019
Sivasaravanaparan, M, Olesen, L Ø, Severino, M, Von Linstow, C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APP SWE/PS1 ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019
BACKGROUND: Modulation of serotonergic signaling by treatment with selective serotonin reuptake inhibitors (SSRIs) has been suggested to mitigate amyloid-β (Aβ) pathology in Alzheimer's disease, in addition to exerting an anti-depressant action.OBJ
Autor:
Mithula Sivasaravanaparan, Ove Wiborg, Louise Ørum Olesen, Elena V. Bouzinova, Alicia A. Babcock, Mark J. West, Bente Finsen, Maurizio Severino
Publikováno v:
Olesen, LØ, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2019, ' Corrigendum to “Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP swe /PS1 dE9 transgenic mice : Effect of long-term treatment with paroxetine" [Neurobiol Dis. 2017; 104: 50-60]. ', Neurobiology of Disease, vol. 124, pp. 573 . https://doi.org/10.1016/j.nbd.2019.01.021
Neurobiology of Disease, Vol 124, Iss, Pp 573-(2019)
Neurobiology of Disease, Vol 124, Iss, Pp 573-(2019)
The photomicrographs of the doublecortic stainings of the dentate gyrus shown in Figure 2A and Figure 2B shall be switched around. Figure 2B presents the 18-month-old WtVeh mouse and Figure 2A presents the TgVeh mouse. The authors would like to apolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5e1d2f0abb52484962bd97ebc4aac4
https://portal.findresearcher.sdu.dk/da/publications/015f1807-08d6-450c-879f-112768d0b4b4
https://portal.findresearcher.sdu.dk/da/publications/015f1807-08d6-450c-879f-112768d0b4b4
Autor:
Athanasios Metaxas, Kate Lykke Lambertsen, Ove Wiborg, Elena V. Bouzinova, Maurizio Severino, Louise Ørum Olesen, Alicia A. Babcock, Asif Manzoor Khan, Jan Bert Gramsbergen, Bente Finsen, Christian Ulrich von Linstow, Mithula Sivasaravanaparan
Publikováno v:
Severino, M, Sivasaravanaparan, M, Olesen, L, von Linstow, C U, Metaxas, A, Bouzinova, E V, Khan, A M, Lambertsen, K L, Babcock, A A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Severino, M, Sivasaravanaparan, M, Olesen, L Ø, von Linstow, C U, Metaxas, A, Bouzinova, E V, Khan, A M, Lambertsen, K L, Babcock, A A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's & Dementia, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Severino, M, Sivasaravanaparan, M, Olesen, L Ø, von Linstow, C U, Metaxas, A, Bouzinova, E, Khan, A M, Lambertsen, K L, Babcock, A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Severino, M, Sivasaravanaparan, M, Olesen, L Ø, von Linstow, C U, Metaxas, A, Bouzinova, E V, Khan, A M, Lambertsen, K L, Babcock, A A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's & Dementia, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Severino, M, Sivasaravanaparan, M, Olesen, L Ø, von Linstow, C U, Metaxas, A, Bouzinova, E, Khan, A M, Lambertsen, K L, Babcock, A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Introduction Treatment with selective serotonin reuptake inhibitors has been suggested to mitigate amyloid-β (Aβ) pathology in Alzheimer's disease, in addition to an antidepressant mechanism of action. Methods We investigated whether chronic treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c597ae314e2f46c7450ddd37fe67e7e
https://pure.au.dk/portal/da/publications/established-amyloid-pathology-is-unaffected-by-chronic-treatment-with-the-selective-serotonin-reuptake-inhibitor-paroxetine(3a59f02c-25d5-4d98-987c-eec9ea91a21a).html
https://pure.au.dk/portal/da/publications/established-amyloid-pathology-is-unaffected-by-chronic-treatment-with-the-selective-serotonin-reuptake-inhibitor-paroxetine(3a59f02c-25d5-4d98-987c-eec9ea91a21a).html
Autor:
Mithula Sivasaravanaparan, Louise Ørum Olesen, Alicia A. Babcock, Elena V. Bouzinova, Bente Finsen, Ove Wiborg, Maurizio Severino, Mark J. West
Publikováno v:
Olesen, L Ø, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2017, ' Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP swe /PS1 dE9 transgenic mice : Effect of long-term treatment with paroxetine ', Neurobiology of Disease, vol. 104, pp. 50-60 . https://doi.org/10.1016/j.nbd.2017.04.021
Olesen, L O, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2017, ' Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice : Effect of long-term treatment with paroxetine ', Neurobiology of Disease, vol. 104, pp. 50-60 . https://doi.org/10.1016/j.nbd.2017.04.021
Neurobiology of Disease, Vol 104, Iss, Pp 50-60 (2017)
Olesen, L O, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2017, ' Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice : Effect of long-term treatment with paroxetine ', Neurobiology of Disease, vol. 104, pp. 50-60 . https://doi.org/10.1016/j.nbd.2017.04.021
Neurobiology of Disease, Vol 104, Iss, Pp 50-60 (2017)
Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8f25716018be6de0012dd443cd518b
https://portal.findresearcher.sdu.dk/da/publications/58bd56a7-b25c-42b8-b573-c6bafef6973a
https://portal.findresearcher.sdu.dk/da/publications/58bd56a7-b25c-42b8-b573-c6bafef6973a
Autor:
Louise Ørum, Olesen, Mithula, Sivasaravanaparan, Maurizio, Severino, Alicia A, Babcock, Elena V, Bouzinova, Mark J, West, Ove, Wiborg, Bente, Finsen
Publikováno v:
Neurobiology of disease. 104
Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transge
Autor:
Kate Lykke Lambertsen, Sergei A. Nedospasov, Mithula Sivasaravanaparan, Torben Fogtmann, Maria Gammelstrup Andersen, Han Gao, Jae K. Lee, Bjarne Winther Kristensen, Tomas Deierborg, Svend Hvidsten, Roberta Brambilla, Michelle Trojanowsky, Bente Finsen, Matilda Degn, Bettina Hjelm Clausen, Christina Baun, Morten Meyer, Sara Thornby Bak
Publikováno v:
Clausen, B H, Degn, M, Sivasaravanaparan, M, Fogtmann, T, Andersen, M G, Trojanowsky, M D, Gao, H, Hvidsten, S, Baun, C, Deierborg, T, Finsen, B, Kristensen, B W, Bak, S T, Meyer, M, Lee, J, Nedospasov, S A, Brambilla, R & Lambertsen, K L 2016, ' Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling ', Scientific Reports, vol. 6, 29291 . https://doi.org/10.1038/srep29291
Scientific Reports
Scientific Reports
Microglia are activated following cerebral ischemia and increase their production of the neuro- and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function of TNF from this cellular source in focal cerebral ischemia we used TNF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03acf14f3931e4d5cf191e497041126
https://findresearcher.sdu.dk:8443/ws/files/129761369/Conditional_ablation_of_myeloid_TNF_increases_lesion_volume_after_experimental_stroke_in_mice_possibly_via_altered_ERK1_2_signaling.pdf
https://findresearcher.sdu.dk:8443/ws/files/129761369/Conditional_ablation_of_myeloid_TNF_increases_lesion_volume_after_experimental_stroke_in_mice_possibly_via_altered_ERK1_2_signaling.pdf
Autor:
Mithula Sivasaravanaparan, Maj Rabjerg, Heike Wulff, Ralf Köhler, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Aida Oliván-Viguera, Nicholas Ditzel, Linda Sevelsted-Møller
Publikováno v:
PLoS ONE
Lambertsen, K L, Gramsbergen, J B, Sivasaravanaparan, M, Ditzel, N, Møller, L M S, Oliván-Viguera, A, Rabjerg, M, Wulff, H & Köhler, R 2012, ' Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels ', P L o S One, vol. 7, no. 10, pp. e47744 . https://doi.org/10.1371/journal.pone.0047744
PloS one, vol 7, iss 10
PLoS ONE, Vol 7, Iss 10, p e47744 (2012)
Lambertsen, K L, Gramsbergen, J B, Sivasaravanaparan, M, Ditzel, N, Møller, L M S, Oliván-Viguera, A, Rabjerg, M, Wulff, H & Köhler, R 2012, ' Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels ', P L o S One, vol. 7, no. 10, pp. e47744 . https://doi.org/10.1371/journal.pone.0047744
PloS one, vol 7, iss 10
PLoS ONE, Vol 7, Iss 10, p e47744 (2012)
Author(s): Lambertsen, Kate Lykke; Gramsbergen, Jan Bert; Sivasaravanaparan, Mithula; Ditzel, Nicholas; Sevelsted-Moller, Linda Maria; Olivan-Viguera, Aida; Rabjerg, Maj; Wulff, Heike; Kohler, Ralf | Abstract: BackgroundThe calmodulin/calcium-activat