Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mithila Tennakoon"'
Autor:
Dhanushan Wijayaratna, Kasun Ratnayake, Sithurandi Ubeysinghe, Dinesh Kankanamge, Mithila Tennakoon, Ajith Karunarathne
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabo
Externí odkaz:
https://doaj.org/article/df310be0c4084b27b867a370bc59ba35
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::441679a06f91fd37f2f1cc5696a05805
https://doi.org/10.1124/jpet.122.558790
https://doi.org/10.1124/jpet.122.558790
Autor:
Waruna Thotamune, Sithurand Ubeysinghe, Ajith Karunarathne, Kendra K. Shrestha, Michael C. Young, Mithila Tennakoon
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d291586ddb44f45e20cbffb5e1368de9
https://doi.org/10.1124/jpet.122.563170
https://doi.org/10.1124/jpet.122.563170
Autor:
Dhanushan Wijayaratna, Kasun Ratnayake, Sithurandi Ubeysinghe, Dinesh Kankanamge, Mithila Tennakoon, Ajith Karunarathne
Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabolism, che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3488d8e3e64fd77b0e9176dce53a4dad
https://doi.org/10.1101/2022.08.31.506078
https://doi.org/10.1101/2022.08.31.506078
Autor:
Ajith Karunarathne, Mithila Tennakoon, Deborah N. Chadee, Kanishka Senarath, Dinesh Kankanamge
Publikováno v:
Molecular Biology of the Cell
G protein beta-gamma (Gβγ) subunits anchor to the plasma membrane (PM) through the carboxy-terminal (CT) prenyl group in Gγ. This interaction is crucial for the PM localization and functioning of Gβγ, allowing GPCR-G protein signaling to proceed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0fae8b04d447661c4c395210d09f08
http://europepmc.org/articles/PMC8351738
http://europepmc.org/articles/PMC8351738
Publikováno v:
Journal of Biological Chemistry. 298:102618
Heterotrimeric G proteins (αβγ subunits) that are activated by G protein-coupled receptors (GPCRs) mediate the biological responses of eukaryotic cells to extracellular signals. The α subunits and the tightly bound βγ subunit complex of G prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cce3ca860962b99baf28fcf4fb8ff51
https://doi.org/10.1016/j.jbc.2022.102618
https://doi.org/10.1016/j.jbc.2022.102618
Publikováno v:
Molecular Pharmacology. 95:361-375
Guanine nucleotide-binding proteins (G proteins) facilitate the transduction of external signals to the cell interior, regulate most eukaryotic signaling, and thus have become crucial disease drivers. G proteins largely function at the inner leaflet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a0513dac44e6c6f0667375e084f0a4
https://doi.org/10.1124/mol.118.114710
https://doi.org/10.1124/mol.118.114710
Autor:
Kimberly Martins-Cannavino, Dinesh Kankanamge, Kasun Ratnayake, Dhanushan Wijayaratna, Kanishka Senarath, Ajith Karunarathne, Terence E. Hébert, Koshala Olupothage, Mithila Tennakoon, Sithurandi Ubeysinghe
Publikováno v:
Cell Signal
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the inner leaflet of the plasma membrane. Though the initial focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405fec568ac1cc2e2797d21976914d85
https://doi.org/10.1016/j.cellsig.2021.109947
https://doi.org/10.1016/j.cellsig.2021.109947
Autor:
Elise Harmon, Dinesh Kankanamge, Kanishka Senarath, Kasun Ratnayake, Mithila Tennakoon, Ajith Karunarathne
Publikováno v:
Anal Bioanal Chem
G protein-coupled receptors (GPCRs), G proteins, and their signaling associates are major signal transducers that control the majority of cellular signaling and regulate key biological functions including immune, neurological, cardiovascular, and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dc51c3677388582adae8e0b1f1401d
https://europepmc.org/articles/PMC6612303/
https://europepmc.org/articles/PMC6612303/