Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mitesh Sanghvi"'
Autor:
Olivier Schueller, Ed Skucas, Galit Regev, Iain Shaw, Nand Singh, Mitesh Sanghvi, Marie Croft, Lauren Lohmer, Anginelle Alabanza, Jeegar Patel
Publikováno v:
Clinical Pharmacology in Drug Development. 11:786-794
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04ccef0f727ce8005aa1ac2d2185514
https://doi.org/10.1002/cpdd.1085
https://doi.org/10.1002/cpdd.1085
Autor:
Brandon Swift, Lee Crossman, Graeme Young, Robin L. O'Connor-Semmes, Megan M. McLaughlin, David Kenworthy, David A. Bershas, Matthew Allinder, Jill L. Pirhalla, Mitesh Sanghvi, Maciej J. Zamek-Gliszczynski, Karl M. Thorpe, Jeremy Dennison, Jennypher Mudunuru, Adrian Pereira
Publikováno v:
Drug Metabolism and Disposition. 49:1109-1117
Linerixibat, an oral small molecule ileal bile acid transporter inhibitor under development for cholestatic pruritus in primary biliary cholangitis, was designed for minimal intestinal absorption (site of pharmacological action). This study character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d996ca482b164fc913af14a3e88ca4f
https://doi.org/10.1124/dmd.121.000595
https://doi.org/10.1124/dmd.121.000595
Autor:
Olivier, Schueller, Ed, Skucas, Galit, Regev, Iain, Shaw, Nand, Singh, Mitesh, Sanghvi, Marie, Croft, Lauren, Lohmer, Anginelle, Alabanza, Jeegar, Patel
Publikováno v:
Clinical pharmacology in drug developmentReferences. 11(7)
Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor. ROCK2 has been shown to drive proinflammatory response and fibrosis that occurs with chronic graft-versus-host disease; therefore, inhibition of ROCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ee06b65c7d01f2c3f3e194c78df4cc9
https://pubmed.ncbi.nlm.nih.gov/35231159
https://pubmed.ncbi.nlm.nih.gov/35231159
Autor:
Maciej J, Zamek-Gliszczynski, David, Kenworthy, David A, Bershas, Mitesh, Sanghvi, Adrian I, Pereira, Jennypher, Mudunuru, Lee, Crossman, Jill L, Pirhalla, Karl M, Thorpe, Jeremy M T J, Dennison, Megan M, McLaughlin, Matthew, Allinder, Brandon, Swift, Robin L, O'Connor-Semmes, Graeme C, Young
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(12)
Linerixibat, an oral small-molecule ileal bile acid transporter inhibitor under development for cholestatic pruritus in primary biliary cholangitis, was designed for minimal absorption from the intestine (site of pharmacological action). This study c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d3fb15060f3d798f11b6424b7918a34
https://pubmed.ncbi.nlm.nih.gov/34625435
https://pubmed.ncbi.nlm.nih.gov/34625435
Autor:
Stacie McCown, Dave Williams, Esme Farley, Jennifer Zimmer, Mark O'Dell, Roger Hayes, Joseph Bower, Ashley Brant, Colin Barry, Todd Lester, Shane Karnik, Elizabeth Groeber, Wei Garofolo, Jennifer Vance, Edward Tabler, Amanda Hays, Dawn Dufield, Marsha Luna, Mitesh Sanghvi, Kurt J. Sales, Rachel Sun, Kelly Dong, Jenny Lin, Anahita Keyhani, Xinping Fang, Orlando Bravo, Natasha Savoie, Steve Lowes, Daksha Desai-Krieger, Allan Xu, Chris Beaver, Cheikh Kane, Sumit Kar, Heidi Renfrew, Christina Satterwhite, Brian K. Hoffpauir, Fabio Garofolo, Sarah Simchik, Stephanie Cape, Rafiq Islam
Publikováno v:
Bioanalysis. 13(8)
The 13th Global CRO Council (GCC) closed forum for bioanalysis was held in New Orleans, LA, USA on 5 April 2019. This GCC meeting was organized to discuss the contents of the 2019 ICH M10 Bioanalytical Method Validation Draft Guideline published in F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19d5fd9051d2b19e757ff72eb64a8a6
https://pubmed.ncbi.nlm.nih.gov/33847160
https://pubmed.ncbi.nlm.nih.gov/33847160
Autor:
Mark Gohdes, J. Greg Slatter, Tim Ingallinera, Hao Sun, Paul G. Pearson, Jerry Evarts, Terry Podoll, Mitesh Sanghvi, Elena Bibikova, Kristen Cardinal
Publikováno v:
Drug Metabolism and Disposition. 47:145-154
Acalabrutinib is a targeted, covalent inhibitor of Bruton tyrosine kinase (BTK) with a unique 2-butynamide warhead that has relatively lower reactivity than other marketed acrylamide covalent inhibitors. A human [14C] microtracer bioavailability stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdd79c4d40f1d5137e0bc6c0ef781ad
https://doi.org/10.1124/dmd.118.084459
https://doi.org/10.1124/dmd.118.084459
Autor:
Kristen Cardinal, Jerry Evarts, Hao Sun, Tim Ingallinera, Paul G. Pearson, Stephen Byard, Mitesh Sanghvi, Terry Podoll, J. Greg Slatter, Mark Gohdes, Elena Bibikova
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S74-S75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cce886f8b1dd8bc28c84eb5ffb3f986
https://doi.org/10.1016/j.dmpk.2020.04.171
https://doi.org/10.1016/j.dmpk.2020.04.171
Autor:
Katina Sourou Sylvestre Dossou, Ruin Moaddel, Mitesh Sanghvi, Ying Xie, Angela D. M. Kashuba, Roy L. Hawke, Gary Asher, Robert S. Sandler
Publikováno v:
The Journal of Clinical Pharmacology. 57:185-193
Curcumin is poorly absorbed, which is interest in new preparations. However, little is known about variations in its pharmacokinetics and tissue bioavailability between formulations. In this randomized, crossover study we evaluated the relationship b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::563f206f54fcdb698134e4c39e2c53ea
https://doi.org/10.1002/jcph.806
https://doi.org/10.1002/jcph.806
Autor:
Zsuzsanna Tucsek, Artur Wnorowski, Ahmed Ali, Mitesh Sanghvi, Stefano Tarantini, Julie A. Mattison, Ruin Moaddel, Irene Alfaras, Devin Wahl, Zoltan Ungvari, Shakeela Faulkner, Anna Csiszar, Kevin J. Pearson, Rafael de Cabo, Michel Bernier, Joanne S. Allard
Publikováno v:
Aging (Albany NY)
Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preventing pancreatic beta cell dysfunction, arterial stiffening and metabolic decline induced by high-fat/high-sugar (HFS) diet in nonhuman primates. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda21fda4059a8d7234fbea81c9ef52b
https://doi.org/10.18632/aging.100942
https://doi.org/10.18632/aging.100942
Autor:
Ruin Moaddel, Mitesh Sanghvi, Marc C. Torjman, Irving W. Wainer, Kathleen O’Loughlin, Michel Bernier, Carol E. Green, Mohammed Khadeer, Nagendra Singh, Rajib K. Paul
Publikováno v:
Anesthesiology. 121:149-159
Background: Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0847fb51d9fd344729cd6209e6cd78f
https://doi.org/10.1097/aln.0000000000000285
https://doi.org/10.1097/aln.0000000000000285