Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Mitesh J. Borad"'
Autor:
Mason J. Webb, Thanich Sangsuwannukul, Jacob van Vloten, Laura Evgin, Benjamin Kendall, Jason Tonne, Jill Thompson, Muriel Metko, Madelyn Moore, Maria P. Chiriboga Yerovi, Michael Olin, Antonella Borgatti, Mark McNiven, Satdarshan P. S. Monga, Mitesh J. Borad, Alan Melcher, Lewis R. Roberts, Richard Vile
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Although patients benefit from immune checkpoint inhibition (ICI) therapy in a broad variety of tumors, resistance may arise from immune suppressive tumor microenvironments (TME), which is particularly true of hepatocellular carcinoma (HCC).
Externí odkaz:
https://doaj.org/article/3cf0fc38fa494b069051f0ff5e7872c6
Publikováno v:
Einstein (São Paulo), Vol 22 (2024)
ABSTRACT Objective Multicancer early detection panels have recently become available to patients with healthcare provider prescriptions and available funds. These tests utilize circulating tumor DNA (ctDNA) to screen more than 50 cancers using a sing
Externí odkaz:
https://doaj.org/article/7ab1086b6c184609beacccbcd5e2e0af
Autor:
Linsey E. Jackson, Jennifer L. Tomlinson, Roberto Alva-Ruiz, Lindsey A. Gregory, Seul Kee Byeon, Amro M. Abdelrahman, Dong-Gi Mun, Caroline W. Grant, Zachary C. Fogarty, Chen Wang, Lewis R. Roberts, Rondell P. Graham, Mitesh J. Borad, Sumera I. Ilyas, Gregory J. Gores, Akhilesh Pandey, Arjun P. Athreya, Rory L. Smoot
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101068- (2024)
Background & Aims: Metabolomic and lipidomic analyses provide an opportunity for novel biological insights. Cholangiocarcinoma (CCA) remains a highly lethal cancer with limited response to systemic, targeted, and immunotherapeutic approaches. Using a
Externí odkaz:
https://doaj.org/article/2c99399c263347e3bad6c6dcc1769f86
Autor:
Chelsae R. Watters, Oumar Barro, Natalie M. Elliott, Yumei Zhou, Musa Gabere, Elizabeth Raupach, Alexander T. Baker, Michael T. Barrett, Kenneth H. Buetow, Bertram Jacobs, Mahesh Seetharam, Mitesh J. Borad, Bolni Marius Nagalo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 4-14 (2023)
Vesiculoviruses are attractive oncolytic virus platforms due to their rapid replication, appreciable transgene capacity, broad tropism, limited preexisting immunity, and tumor selectivity through type I interferon response defects in malignant cells.
Externí odkaz:
https://doaj.org/article/0f9b4133faac47bdbaa01ba69e5b9a37
Autor:
Ghassan K. Abou-Alfa, Peter R. Galle, Yee Chao, Joseph Erinjeri, Jeong Heo, Mitesh J. Borad, Angelo Luca, James Burke, Adina Pelusio, Delphine Agathon, Monika Lusky, Caroline Breitbach, Shukui Qin, Edward Gane
Publikováno v:
Liver Cancer, Pp 1-1 (2023)
Introduction Intratumoral administration of pexa-vec (Pexastimogene Devacirepvec), an oncolytic and immunotherapeutic vaccinia virus. given to patients with hepatocellular carcinoma (HCC), is associated with both local and distant tumor responses. We
Externí odkaz:
https://doaj.org/article/bdd152f1ab754f309e25b0ec1686e9ea
Autor:
Deepak Thirunavukarasu, Lauren Y. Cheng, Ping Song, Sherry X. Chen, Mitesh J. Borad, Lawrence Kwong, Phillip James, Daniel J. Turner, David Yu Zhang
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract We develop the Oncogene Concatenated Enriched Amplicon Nanopore Sequencing (OCEANS) method, in which variants with low variant allele frequency (VAFs) are amplified and subsequently concatenated for Nanopore Sequencing. OCEANS allows accurat
Externí odkaz:
https://doaj.org/article/4bf551b9432b4350a7d2d7853a93be54
Autor:
Yuguo Zhang, Musa Gabere, Mika A. Taylor, Camila C. Simoes, Chelsae Dumbauld, Oumar Barro, Mulu Z. Tesfay, Alicia L. Graham, Khandoker Usran Ferdous, Alena V. Savenka, Jean Christopher Chamcheu, Charity L. Washam, Duah Alkam, Allen Gies, Stephanie D. Byrum, Matteo Conti, Steven R. Post, Thomas Kelly, Mitesh J. Borad, Martin J. Cannon, Alexei Basnakian, Bolni M. Nagalo
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
It has long been known that oncolytic viruses wield their therapeutic capability by priming an inflammatory state within the tumor and activating the tumor immune microenvironment, resulting in a multifaceted antitumor immune response. Vaccine-derive
Externí odkaz:
https://doaj.org/article/cc4969f03b474994ad64d25b34a6caa6
Autor:
Timothy Kottke, Jason Tonne, Laura Evgin, Christopher B. Driscoll, Jacob van Vloten, Victoria A. Jennings, Amanda L. Huff, Brady Zell, Jill M. Thompson, Phonphimon Wongthida, Jose Pulido, Matthew R. Schuelke, Adel Samson, Peter Selby, Elizabeth Ilett, Mark McNiven, Lewis R. Roberts, Mitesh J. Borad, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard G. Vile
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Oncolytic viruses, such as vesicular stomatitis virus (VSV), are a promising class of cancer therapeutics. Here the authors report that a mutation in the CSDE1 gene renders cancer cells resistant to VSV replication and oncolysis, but a mutation-deriv
Externí odkaz:
https://doaj.org/article/0057781c39ce43a79a6659f6e847a415
Autor:
Yan W. Asmann, Kaushal Parikh, P. Leif Bergsagel, Haidong Dong, Alex A. Adjei, Mitesh J. Borad, Aaron S. Mansfield
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-4 (2021)
Abstract With the recent FDA approval of tumor mutational burden-high (TMB-H) status as a biomarker for treatment with a PD-1 inhibitor regardless of tumor type, accurate assessment of patient-specific TMB is more critical now more than ever. Using p
Externí odkaz:
https://doaj.org/article/953d0fc861874af3a5542c24c24ac1b0
Autor:
Bolni Marius Nagalo, Camilo Ayala Breton, Yumei Zhou, Mansi Arora, James M. Bogenberger, Oumar Barro, Michael B. Steele, Nathan J. Jenks, Alexander T. Baker, Dan G. Duda, Lewis Rowland Roberts, Stephen J. Russell, Kah Whye Peng, Mitesh J. Borad
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 546-555 (2020)
Recombinant vesicular stomatitis virus (VSV)-fusion and hemagglutinin (FH) was developed by substituting the promiscuous VSV-G glycoprotein (G) gene in the backbone of VSV with genes encoding for the measles virus envelope proteins F and H. Hybrid VS
Externí odkaz:
https://doaj.org/article/cf8b83d79ce84bd7ac031006f36cdbad