Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.

Autor: Wertz MH; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mitchem MR; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pineda SS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA., Hachigian LJ; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lee H; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lau V; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Powers A; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kulicke R; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Madan GK; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Colic M; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Therrien M; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vernon A; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Beja-Glasser VF; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, Cambridge, MA 02139, USA., Hegde M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gao F; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Bioinformatics Resource Center in the Beckman Institute at Caltech, Pasadena, CA 91125, USA., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA., Hart T; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Heiman M; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: mheiman@mit.edu.

Publikováno v: Neuron [Neuron] 2020 Apr 08; Vol. 106 (1), pp. 76-89.e8. Date of Electronic Publication: 2020 Jan 30.

"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice.

Autor: Coughlan KS; Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland., Mitchem MR; Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland., Hogg MC; Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland., Prehn JH; Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: JPrehn@rcsi.ie.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2015 Feb; Vol. 36 (2), pp. 1140-50. Date of Electronic Publication: 2014 Sep 26.

Time-Dependent Compensatory Responses to Chronic Neuroinflammation in Hippocampus and Brainstem: The Potential Role of Glutamate Neurotransmission.

Autor: Brothers HM; Department of Psychology, Ohio State University, Columbus, OH, USA., Bardou I; Department of Psychology, Ohio State University, Columbus, OH, USA., Hopp SC; Department of Neuroscience, Ohio State University, Columbus, OH, USA., Marchalant Y; NICN, UMR 6184, Université de la Méditerranée, Marseille, France., Kaercher RM; Department of Psychology, Ohio State University, Columbus, OH, USA., Turner SM; Department of Psychology, Ohio State University, Columbus, OH, USA., Mitchem MR; Department of Psychology, Ohio State University, Columbus, OH, USA., Kigerl K; Department of Neuroscience, Ohio State University, Columbus, OH, USA., Wenk GL; Department of Psychology, Ohio State University, Columbus, OH, USA.

Publikováno v: Journal of Alzheimer's disease & Parkinsonism [J Alzheimers Dis Parkinsonism] 2013 Mar 28; Vol. 3, pp. 110.