Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Mitchell V Hull"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008353 (2020)
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia mandril
Externí odkaz:
https://doaj.org/article/cc1de70502d44438b391b66a2a7f3dfd
Autor:
Mario Carucci, Julien Duez, Joel Tarning, Irene García-Barbazán, Aurélie Fricot-Monsinjon, Abdoulaye Sissoko, Lucie Dumas, Pablo Gamallo, Babette Beher, Pascal Amireault, Michael Dussiot, Ming Dao, Mitchell V. Hull, Case W. McNamara, Camille Roussel, Papa Alioune Ndour, Laura Maria Sanz, Francisco Javier Gamo, Pierre Buffet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Authors propose their splenic mimetic filtration method, microsphiltration, and utilise this approach in a drug-screen, to identify compounds that induce a stiffening effect on Plasmodium falciparum-infected erythrocytes. They proceed to assess safet
Externí odkaz:
https://doaj.org/article/12698d4c89d84fc19fe9d82eeccb5f13
Autor:
Jean A. Bernatchez, Emily Chen, Mitchell V. Hull, Case W. McNamara, James H. McKerrow, Jair L. Siqueira-Neto
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 472 (2020)
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, affects between 6 and 7 million people worldwide, with an estimated 300,000 to 1 million of these cases in the United States. In the chronic phase of infection, T. cruzi can caus
Externí odkaz:
https://doaj.org/article/82e0aa90e04d44c59825e25e98d6ef55
Autor:
Leopold Garnar-Wortzel, K. Barry Sharpless, Anissa R. Ramos, Arnab K. Chatterjee, Mitchell V. Hull, Michael A. Erb, Joshua N. Asiaban, Travis S. Young, Xiaoyu Zhang, Emily Chen, Seiya Kitamura, Eric N. Hampton, Timothy R. Bishop, Natalia Milosevich, Benjamin F. Cravatt, Christopher J. Ackerman, Qinheng Zheng, Dennis W. Wolan
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 815-830 (2021)
ACS Central Science
ACS Central Science
Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93f755387e1a9323b5f36d3d783a332
https://doi.org/10.1021/acscentsci.0c01550
https://doi.org/10.1021/acscentsci.0c01550
Autor:
Patrick R. Griffin, Michael Farzan, Louis Scampavia, Emery Smith, Pierre Baillargeon, Tu Trinh Nguyen, Mitchell V. Hull, Timothy S. Strutzenberg, Meredith E. Davis-Gardner, Ruben D. Garcia-Ordonez, Timothy P. Spicer, Emily Chen
Publikováno v:
SLAS Discovery. 25:1152-1161
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 has triggered an ongoing global pandemic whereby infection may result in a lethal severe pneumonia-like disease designated as coronavirus disease 2019 (COVID-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b296a8834eb316f6af8b2cb7bdd7394
https://doi.org/10.1177/2472555220963667
https://doi.org/10.1177/2472555220963667
Autor:
Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Lars Pache, Sebastian Burgstaller-Muehlbacher, Paul D. De Jesus, Peter Teriete, Mitchell V. Hull, Max W. Chang, Jasper Fuk-Woo Chan, Jianli Cao, Vincent Kwok-Man Poon, Kristina M. Herbert, Kuoyuan Cheng, Tu-Trinh H. Nguyen, Andrey Rubanov, Yuan Pu, Courtney Nguyen, Angela Choi, Raveen Rathnasinghe, Michael Schotsaert, Lisa Miorin, Marion Dejosez, Thomas P. Zwaka, Ko-Yung Sit, Luis Martinez-Sobrido, Wen-Chun Liu, Kris M. White, Mackenzie E. Chapman, Emma K. Lendy, Richard J. Glynne, Randy Albrecht, Eytan Ruppin, Andrew D. Mesecar, Jeffrey R. Johnson, Christopher Benner, Ren Sun, Peter G. Schultz, Andrew I. Su, Adolfo García-Sastre, Arnab K. Chatterjee, Kwok-Yung Yuen, Sumit K. Chanda
Publikováno v:
Nature
Summary The emergence of the novel SARS coronavirus 2 (SARS-CoV-2) in 2019 has triggered an ongoing global pandemic of severe pneumonia-like disease designated as coronavirus disease 2019 (COVID-19)1. The development of a vaccine is likely to require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec8b07864daa4712214c5022636c8e8
https://doi.org/10.1038/s41586-020-2577-1
https://doi.org/10.1038/s41586-020-2577-1
Autor:
Seiya Kitamura, Qinheng Zheng, Nicholas Dillon, Angelo Solania, Jordan L. Woehl, Miyako Kotaniguchi, John R. Cappiello, Shinichi Kitamura, Dennis W. Wolan, Victor Nizet, Mitchell V. Hull, Emily I. Chen, K. Barry Sharpless
Publikováno v:
J Am Chem Soc
Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf71ebb2630949782c503b6d31383a09
https://doi.org/10.1021/jacs.9b13652
https://doi.org/10.1021/jacs.9b13652
Autor:
Lennart Brewitz, David I. Stuart, Anthony Tumber, Petra Lukacik, Chris J Radoux, Laura Vangeel, Christopher J. Schofield, M.A. Redhead, Pieter Leyssen, David J. Hallett, Claire Strain-Damerell, Sean W. Robinson, Mitchell V. Hull, Jan Thibaut, Patrick Collins, Martin A. Walsh, Tika R. Malla, Mark Swindells, Alice Douangamath, Iva Navratilova Hopkins, Tu-Trinh Nguyen, Philipp Schäfer, Amelia H. Collette, C. David Owen, Thomas Vercruysse, D. Fearon, A.L. Hopkins, Frank von Delft
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ad9c0d8c557f75ac175f3cfba52f9f
https://doi.org/10.1038/s41598-021-99041-1
https://doi.org/10.1038/s41598-021-99041-1
Autor:
Pierre Baillargeon, Huihui Mou, S. Valente, Thomas D. Bannister, S. Jablonski, Timothy P. Spicer, Louis Scampavia, Lalit Batra, Michael Farzan, Christopher Rood, Tu-Trinh Nguyen, Mitchell V. Hull, J. Jablonski, Robert S. Adcock, Donghoon Chung, Emily Chen, X. Yu, Sultan Ullah, R. Rahaim, I. M. de Vera, Yuka Otsuka
The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a persistent threat to mankind, especially for the immunocompromised and elderly for which the vaccine may have limited effectiveness. Entry of SARS-CoV-2 requires a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d8ff4b4daeea7630fd2c9c3efdb82c
https://doi.org/10.1101/2021.08.05.455262
https://doi.org/10.1101/2021.08.05.455262
Autor:
Mitchell V. Hull, Emily I. Chen, Michael J. Bollong, Jonathan Iaconelli, Lara Ibrahim, Peter G. Schultz
Publikováno v:
ChemBioChem. 21:1816-1819
The transcription factor nuclear factor erythroid 2-related factor 1 (NRF1) maintains proteostasis and promotes cellular resilience by stimulating the transcription of proteasomal subunits and a host of protective enzymes. Although NRF1 activation wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7782a487d8f754da56c1e5b01cb777cb
https://doi.org/10.1002/cbic.201900487
https://doi.org/10.1002/cbic.201900487