Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mitchell Thorn"'
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Supplemental Figure 1. In vitro cytotoxicity assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e4f36b3128e8a08781410abb288250
https://doi.org/10.1158/1078-0432.22458323
https://doi.org/10.1158/1078-0432.22458323
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Purpose: Chimeric antigen receptor–modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases, a major cause of death i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c749b8413a71355a55dddb9a20c880e
https://doi.org/10.1158/1078-0432.c.6523904.v1
https://doi.org/10.1158/1078-0432.c.6523904.v1
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Supplemental Figure 4. Cytokine response to treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07639feef77b2ee62051a41eed87b308
https://doi.org/10.1158/1078-0432.22458314
https://doi.org/10.1158/1078-0432.22458314
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Supplemental Figure 3. Radiographic studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc3ca32bc6c13ae1f09ab26cef4d090
https://doi.org/10.1158/1078-0432.22458317
https://doi.org/10.1158/1078-0432.22458317
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Supplemental Figure 2. Flow cytometry gating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa7e5a7eacdefc366bf6ba0e0a7d272
https://doi.org/10.1158/1078-0432.22458320.v1
https://doi.org/10.1158/1078-0432.22458320.v1
Autor:
Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jessie Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefanus Johannes Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent, Gabriel Berstein
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Autor:
Marissa Cunetta, N J Espat, George Miller, Richard P. Junghans, Mitchell Thorn, Steven C. Katz, Prajna Guha
Publikováno v:
Cancer Gene Therapy. 23:188-198
Assumptions that liver immune cells and immunosuppressive pathways are similar to their counterparts in other spaces have led to gaps in our understanding of intrahepatic neoplasm aggressiveness. Myeloid-derived suppressor cells (MDSCs) are potent in
Autor:
Gary Point, Steven C. Katz, Richard P. Junghans, N J Espat, Cherif Boutros, Nader Hanna, Marissa Cunetta, Prajna Guha, Mitchell Thorn
Publikováno v:
Cancer gene therapy
Metastatic spread of colorectal cancer (CRC) to the peritoneal cavity is common and difficult to treat, with many patients dying from malignant bowel obstruction. Chimeric antigen receptor T cell (CAR-T) immunotherapy has shown great promise, and we
Autor:
Alfred Ayala, Prajna Guha, Cang T. Nguyen, Gary Point, Ronald P. DeMatteo, Richard P. Junghans, Mitchell Thorn, Rachel A. Burga, Lauren A. Licata, Steven C. Katz, N. Joseph Espat
Publikováno v:
Cancer Immunology, Immunotherapy. 64:817-829
Chimeric antigen receptor-modified T cell (CAR-T) technology, a promising immunotherapeutic tool, has not been applied specifically to treat liver metastases (LM). While CAR-T delivery to LM can be optimized by regional intrahepatic infusion, we prop
Autor:
Mitchell Thorn, Robin Davies, Brian F. Stainken, Abdul Saied, Elise McCormack, Richard P. Junghans, E O Assanah, Lauren A. Licata, N J Espat, Steven C. Katz, Rachel A. Burga, P D Khare
Publikováno v:
Cancer gene therapy
Our phase I Hepatic Immunotherapy for Metastases (HITM) trial tested the safety of chimeric antigen receptor-modified T-cell (CAR-T) hepatic artery infusions (HAI) for unresectable carcinoembryonic antigen (CEA)+ liver metastases (LM). High neutrophi