Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mitchell S. Dushay"'
Autor:
Andrés Muñoz-Alarcón, Maja Pavlovic, Jasmine Wismar, Bertram Schmitt, Maria Eriksson, Per Kylsten, Mitchell S Dushay
Publikováno v:
PLoS ONE, Vol 2, Iss 6, p e532 (2007)
Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function. Vertebrate A-type lamins are expressed in differentiating cells
Externí odkaz:
https://doaj.org/article/fb1f6bd5a64848d4b367da13dd1d2b95
Autor:
David H. Harter, Benjamin Cohen, Mitchell S. Dushay, Rajan Jain, Thomas A. Neubert, Matthias A. Karajannis, Guoan Zhang, Pamela Wu, Seema Shroff, Jason Reidy, Matija Snuderl, Jeffrey H. Wisoff, Valerio Ortenzi, Tara S. Jennings, David Fenyö, David Zagzag
Publikováno v:
The American journal of pathology. 187(8)
Optic gliomas are brain tumors characterized by slow growth, progressive loss of vision, and limited therapeutic options. Optic gliomas contain various amounts of myxoid matrix, which can represent most of the tumor mass. We sought to investigate bio
Publikováno v:
Developmental & Comparative Immunology. 42:42-46
Drosophila has been increasingly used as a model to study hemolymph clotting. Proteomics and bioinformatics identified candidate clotting-factors, several of which were tested using genetics. Mutants and lines with reduced expression of clotting-fact
Autor:
Molly Zych, Clara Bajzek, Nadia Odell, Nicole Green, Zong-Heng Wang, Kevin R. Cook, Mitchell S. Dushay, Cheryl Clark, Bridget Biersmith, Erika R. Geisbrecht
Publikováno v:
Genetics. 204(3)
The organization and stability of higher order structures that form in the extracellular matrix (ECM) to mediate the attachment of muscles are poorly understood. We have made the surprising discovery that a subset of clotting factor proteins are also
Publikováno v:
Journal of Insect Physiology. 58:1376-1381
Drosophila larval coagulation factors have been identified in vitro. Better understanding of insect hemolymph coagulation calls for experiments in vivo. We have characterized a fondue (fon) mutation and null alleles isolated by imprecise excision of
Autor:
Mitchell S. Dushay
Publikováno v:
Cellular and Molecular Life Sciences. 66:2643-2650
The clot's appearance in different large-bodied insects has been described, but until recently, little was known about any insect clot's molecular makeup, and few experiments could directly test its function. Techniques have been developed in Drosoph
Autor:
Ulrich Theopold, Mitchell S. Dushay
Publikováno v:
Current Immunology Reviews. 3:276-288
Insect immune systems which lack the type of adaptive immunity known in vertebrates rely on several mechanisms including solid barriers against the environment, rapid coagulation of hemolymph after wounding, the formation of aggregates that immobiliz
Autor:
Christine Lesch, Thomas Hauling, Marco Fabbri, Mitchell S. Dushay, Ulrich Theopold, Ahmed M. Korayem, Olga Loseva, Otto Schmidt, Malin Lindgren
Publikováno v:
Biochemical and Biophysical Research Communications. 352:317-322
Hemolymph coagulation stops bleeding and protects against infection. Clotting factors include both proteins that are conserved during evolution as well as more divergent proteins in different species. Here we show that several silk proteins also appe
Publikováno v:
Developmental & Comparative Immunology. 31:1255-1263
Hemolectin has been identified as a candidate clotting factor in Drosophila. We reassessed the domain structure of Hemolectin (Hml) and propose that instead of C-type lectin domains, the two discoidin domains are most likely responsible for the prote
Publikováno v:
Developmental & Comparative Immunology. 29:669-679
Hemolymph coagulation is a first response to wounding in insects. Although studies have been performed in large-bodied insects such as the moth Galleria mellonella, less is known about clotting in Drosophila melanogaster, the insect most useful for g