Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mitchell P. McInerney"'
Autor:
Colin W. Pouton, Shadabul Haque, Endri Kastrati, Vincent Jannin, Mitchell P. McInerney, David K. Chalmers, Karen M. Corbett, Christopher J.H. Porter, Leigh Ford, Hassan Benameur, Hywel David Williams, Dallas B. Warren
Publikováno v:
Pharmaceutical Research. 38:1531-1547
Molecular dynamics (MD) simulations provide an in silico method to study the structure of lipid-based formulations (LBFs) and the incorporation of poorly water-soluble drugs within such formulations. In order to validate the ability of MD to effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808af6cfd8a6e523d490d015ec480b6
https://doi.org/10.1007/s11095-021-03099-5
https://doi.org/10.1007/s11095-021-03099-5
Autor:
Philip E. Thompson, Hywel David Williams, Peter J. Scammells, Shadabul Haque, Mitchell P. McInerney, Peng Li, Hassan Benameur, Vincent Jannin, Christopher J.H. Porter, Colin W. Pouton, Leigh Ford
Publikováno v:
Pharmaceutical Research. 38:1125-1137
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these barriers, effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b12d9de7c2a9f94d3ad127d5c492292
https://doi.org/10.1007/s11095-021-03063-3
https://doi.org/10.1007/s11095-021-03063-3
Autor:
Mitchell P. McInerney, Joseph A. Nicolazzo, Irene Volitakis, Yijun Pan, Ashley I. Bush, Jennifer L. Short
Publikováno v:
Journal of pharmaceutical sciences. 108(7)
Previous studies have demonstrated that the ionophore clioquinol (CQ), in conjunction with the biometals copper and zinc, increases the expression of P-glycoprotein (P-gp) in human cerebral microvascular endothelial (hCMEC/D3) cells. As P-gp expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8bbac78860e0c4d7d1da422db4c3a6
https://pubmed.ncbi.nlm.nih.gov/30738852
https://pubmed.ncbi.nlm.nih.gov/30738852
Autor:
Ashley I. Bush, Joseph A. Nicolazzo, Irene Volitakis, Mitchell P. McInerney, Jennifer L. Short, William A. Banks
Publikováno v:
Pharmaceutical research. 35(4)
Biometals such as zinc and copper have been shown to affect tight junction expression and subsequently blood-brain barrier (BBB) integrity. Whether these biometals also influence the expression and function of BBB transporters such as P-glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341bc1b9835e44afb34d8dfd51a5c63d
https://pubmed.ncbi.nlm.nih.gov/29508078
https://pubmed.ncbi.nlm.nih.gov/29508078
Publikováno v:
The AAPS journal. 19(4)
Despite a century of steady and incremental progress toward understanding the underlying biochemical mechanisms, Alzheimer's disease (AD) remains a complicated and enigmatic disease, and greater insight will be necessary before substantive clinical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6362a968bda0e290223173f190e43d0e
https://pubmed.ncbi.nlm.nih.gov/28462473
https://pubmed.ncbi.nlm.nih.gov/28462473
Publikováno v:
Journal of pharmaceutical sciences. 106(9)
An in-cell western (ICW) protocol detecting the relative expression of P-glycoprotein (P-gp) in human cerebro-microvascular endothelial cells (hCMEC/D3) was developed and optimized, with the intention of improving throughput relative to western blott
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dfd9ad416750059e0e84bf47d19b74
https://pubmed.ncbi.nlm.nih.gov/28065764
https://pubmed.ncbi.nlm.nih.gov/28065764
Autor:
Mitchell P. McInerney, Joseph A. Nicolazzo, Jian Li, Roger L. Nation, Kade D. Roberts, Tony Velkov, Philip E. Thompson
Publikováno v:
Journal of pharmaceutical sciences. 105(2)
The frequency of polymyxin-resistant pathogenic Gram-negative bacteria appearing in the clinic is increasing, and the consequences are largely mediated by modification of lipopolysaccharide (LPS) in the outer membrane. As polymyxins exert their antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ced4e6f40c26bf3da28d5fa98f0a2c
https://pubmed.ncbi.nlm.nih.gov/26869441
https://pubmed.ncbi.nlm.nih.gov/26869441