Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mitchell P. Christy"'
Autor:
Anthony J. O’Donoghue, William H. Gerwick, Dennis W. Wolan, Michael C Yoon, Angelo Solania, Gregory Hook, Zhenze Jiang, Sonia Podvin, Christopher B. Lietz, Mitchell P. Christy, Vivian Hook, Charles Mosier, Gen Ito
Publikováno v:
ACS Chemical Biology. 16:1628-1643
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation and cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398c823ce5d9657c488f430417ed8685
https://doi.org/10.1021/acschembio.1c00138
https://doi.org/10.1021/acschembio.1c00138
Publikováno v:
Synthesis. 53:498-508
The increased resistance of bacteria to clinical antibiotics is one of the major dilemmas facing human health and without solutions the problem will grow exponentially worse. Thiopeptide natural products have shown promising antibiotic activities and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b300a32f47150ef4c8c4d37e97949fe
https://doi.org/10.1055/s-0040-1706478
https://doi.org/10.1055/s-0040-1706478
Autor:
Bryant Lim, Tiffany L Hamilton, Andrew T. Nelson, Mitchell P. Christy, Trevor C. Johnson, Clare McNerlin, Dionicio Siegel, John Woodard, Kaitlyn M Freiberg
Publikováno v:
Organic Letters. 22:2365-2370
Thiopeptides are a class of natural products with untapped therapeutic potential. To expand the methods available for the scaled production of these antibiotics, we report the laboratory synthesis of micrococcin P1 showcasing thiazole forming reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae70b4d3d04ca9f692c8180b0671d93
https://doi.org/10.1021/acs.orglett.0c00202
https://doi.org/10.1021/acs.orglett.0c00202
Autor:
Michael C. Yoon, Mitchell P. Christy, Von V. Phan, William H. Gerwick, Gregory Hook, Anthony J. O’Donoghue, Vivian Hook
Publikováno v:
Biochemistry, vol 61, iss 4
Biochemistry
Biochemistry
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b70cd637f396d21a3714de260fe39f9
https://escholarship.org/uc/item/0rv2s1b3
https://escholarship.org/uc/item/0rv2s1b3
Publikováno v:
Journal of natural products, vol 84, iss 1
Journal of Natural Products
Journal of Natural Products
Three families of RNA viruses, the Coronaviridae, Flaviviridae, and Filoviridae, collectively have great potential to cause epidemic disease in human populations. The current SARS-CoV-2 (Coronaviridae) responsible for the COVID-19 pandemic underscore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2750ff29d92b5e2cb3b92a69b66b1479
https://escholarship.org/uc/item/5d49p9w6
https://escholarship.org/uc/item/5d49p9w6
Autor:
Manuela Raffatellu, Julie C. Lumeng, Emily C. Gentry, Pieter C. Dorrestein, Anupriya Tripathi, Barbara I. Kazmierczak, Sarkis K. Mazmanian, Clary B. Clish, Curtis Huttenhower, Marie E. Egan, Ryan D. Welch, Hera Vlamakis, Ronald M. Evans, Ruchi Jain, Morgan Panitchpakdi, Alexis C. Komor, Michael J. Meehan, Michael Downes, Robert Bussell, Andrew T. Nelson, Ting Fu, Taren Thron, Melissa Ann Quinn, Jason Lloyd-Price, William J. Sandborn, Rob Knight, Alexander A. Aksenov, Ramnik J. Xavier, Eric A. Franzosa, Alexey V. Melnik, Dionicio Siegel, Pedro Belda-Ferre, Lawton K. Chung, Zsolt Bodai, Greg Humphrey, Orit Poulsen, Sena Bae, Brigid S. Boland, Kathryn A. Patras, Kyung E. Rhee, Robert A. Quinn, Alison Vrbanac, John T. Chang, Ricardo Silva, Mitchell P. Christy, Gabriel G. Haddad, Fernando Vargas, Julia M. Gauglitz, Victor Nizet, Julian Avila-Pacheco, Timothy D. Arthur, Neha Garg, David P. Ferguson, Himel Mallick, Mingxun Wang, Eric C. Leszczynski, Kelly C. Weldon, Meerana Lim
Publikováno v:
Nature, vol 579, iss 7797
A mosaic of cross-phylum chemical interactions occurs between all metazoans and their microbiomes. A number of molecular families that are known to be produced by the microbiome have a marked effect on the balance between health and disease1–9. Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fae32db1daaf4f551051bc534e25f19
https://resolver.caltech.edu/CaltechAUTHORS:20200303-123932684
https://resolver.caltech.edu/CaltechAUTHORS:20200303-123932684
Autor:
da Silva Ramos R, Mitchell P. Christy, Nizet, Fernando Vargas, Alison Vrbanac, Dionicio Siegel, John T. Chang, Lim M, Anupriya Tripathi, Orit Poulsen, Rob Knight, Pieter C. Dorrestein, Michael J. Meehan, Kathryn A. Patras, Brigid S. Boland, Julia Gauglitz, Taren Thron, Kyung E. Rhee, Robert A. Quinn, Barbara I. Kazmierczak, Neha Garg, Robert Bussell, Julie C. Lumeng, Mingxun Wang, Alexander A. Aksenov, Sarkis K. Mazmanian, Marie E. Egan, William J. Sandborn, Greg Humphrey, Gabriel G. Haddad, Rishi K. Jain, Andrew T. Nelson, Alexey V. Melnik
A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly adapted and ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7794995421a15cca9a2a4747781fb93a
https://doi.org/10.1101/654756
https://doi.org/10.1101/654756
Autor:
Mitchell P. Christy, Tina Chang, Barbara B. Kahn, Meric Erikci Ertunc, Dionicio Siegel, Lena Ohlsson, Magnus Härröd, Andrew T. Nelson, Matthew J. Kolar, Alan Saghatelian
Publikováno v:
Analytical chemistry, vol 90, iss 8
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of endogenous lipids with anti-diabetic and anti-inflammatory activities. Interest in these lipids is due to their unique biological activity and the observation that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81beeb7b5520a0de0e7ef009d3df2e32
https://pubmed.ncbi.nlm.nih.gov/29578702
https://pubmed.ncbi.nlm.nih.gov/29578702
Autor:
Anders M. Eliasen, Karin R. Claussen, Ronald Besandre, Randal P. Thedford, Mitchell P. Christy, Dionicio Siegel
Publikováno v:
Organic Letters. 17:4420-4423
A new oxidative dearomatization reaction has been developed using phthaloyl peroxide to chemoselectively install two oxygen-carbon bonds into aromatic precursors. The oxidation reaction proceeds only once; addition of superstoichiometric equivalents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2539d22bc0ab734843faedb790854ce0
https://doi.org/10.1021/acs.orglett.5b02008
https://doi.org/10.1021/acs.orglett.5b02008