Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mitchell P Ledwith"'
Autor:
Steven F Baker, Helene Meistermann, Manuel Tzouros, Aaron Baker, Sabrina Golling, Juliane Siebourg Polster, Mitchell P Ledwith, Anthony Gitter, Angelique Augustin, Hassan Javanbakht, Andrew Mehle
Publikováno v:
PLoS Biology, Vol 20, Iss 12, p e3001934 (2022)
Viruses must balance their reliance on host cell machinery for replication while avoiding host defense. Influenza A viruses are zoonotic agents that frequently switch hosts, causing localized outbreaks with the potential for larger pandemics. The hos
Externí odkaz:
https://doaj.org/article/09649af87e6d41eaa961fc4a034da8e8
Autor:
Mitchell P. Ledwith, Vy Tran, Thiprampai Thamamongood, Christina A. Higgins, Shashank Tripathi, Max W. Chang, Christopher Benner, Adolfo García-Sastre, Martin Schwemmle, Adrianus C. M. Boon, Michael S. Diamond, Andrew Mehle
Publikováno v:
Proceedings, Vol 50, Iss 1, p 134 (2020)
Hosts mount prudently tuned responses to viral infection in an attempt to block nearly every step of the replication cycle. Viruses must adapt to replicate in this hostile antiviral cellular state. Interferon stimulation or pathogen challenge robustl
Externí odkaz:
https://doaj.org/article/1682a874e2d44853a040dd199fbb069a
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2581-2588.e4 (2018)
Summary: Adaptation of viruses to their hosts can result in specialization and a restricted host range. Species-specific polymorphisms in the influenza virus polymerase restrict its host range during transmission from birds to mammals. ANP32A was rec
Externí odkaz:
https://doaj.org/article/4634c5b8b6a94e1596c2943656e913f4
Autor:
Juliane Siebourg Polster, Angélique Augustin, Hassan Javanbakht, Sabrina Golling, Mitchell P. Ledwith, Manuel Tzouros, Andrew Mehle, Aaron Baker, Anthony Gitter, Steven F. Baker, Hélène Meistermann
Viruses must balance their reliance on host cell machinery for replication while avoiding host defense. They often exploit conserved essential host genes whose critical role for the cell limits mutational escape. Conversely, host antiviral genes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a41d5b6afe19e84ebb2656613768a7a
https://doi.org/10.1101/2020.11.09.355982
https://doi.org/10.1101/2020.11.09.355982
Autor:
Martin Schwemmle, Thiprampai Thamamongood, Christina A. Higgins, Christopher Benner, Shashank Tripathi, Michael S. Diamond, Mitchell P. Ledwith, Max W. Chang, Vy Tran, Adrianus C. M. Boon, Andrew Mehle, Adolfo García-Sastre
Publikováno v:
Proceedings, Vol 50, Iss 134, p 134 (2020)
Hosts mount prudently tuned responses to viral infection in an attempt to block nearly every step of the replication cycle. Viruses must adapt to replicate in this hostile antiviral cellular state. Interferon stimulation or pathogen challenge robustl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1194d7e575101d74918293468bd0fe82
https://www.mdpi.com/2504-3900/50/1/134
https://www.mdpi.com/2504-3900/50/1/134
Autor:
Max W. Chang, Mitchell P. Ledwith, Andrew Mehle, Adolfo García-Sastre, Michael S. Diamond, Vy Tran, Shashank Tripathi, Adrianus C. M. Boon, Christina A. Higgins, Christopher Benner, Thiprampai Thamamongood, Martin Schwemmle
Publikováno v:
Nature microbiology
Nature microbiology, vol 5, iss 12
Nature microbiology, vol 5, iss 12
Cells infected by influenza virus mount a large-scale antiviral response and most cells ultimately initiate cell-death pathways in an attempt to suppress viral replication. We performed a CRISPR-Cas9-knockout selection designed to identify host facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56ffc8f271eb93548a15db791d4e4e2
https://pubmed.ncbi.nlm.nih.gov/32839537
https://pubmed.ncbi.nlm.nih.gov/32839537
Publikováno v:
Virology. 510:137-146
Ataxia-Telangiectasia mutated (ATM) kinase participates in multiple networks, including DNA damage response, oxidative stress, and mitophagy. ATM also supports replication of diverse DNA and RNA viruses. Gammaherpesviruses are prevalent cancer-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2642244550680bae24bdef86c0b694c3
https://doi.org/10.1016/j.virol.2017.07.014
https://doi.org/10.1016/j.virol.2017.07.014
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2581-2588.e4 (2018)
Summary: Adaptation of viruses to their hosts can result in specialization and a restricted host range. Species-specific polymorphisms in the influenza virus polymerase restrict its host range during transmission from birds to mammals. ANP32A was rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f089dbdbd713d5dcdab33907de012495
Autor:
Philip T. Lange, Wadzanai P. Mboko, Michaela M. Rekow, Sean Anderson, Mitchell P. Ledwith, Kaitlin E. Schmitz, Vera L. Tarakanova
Publikováno v:
Journal of Virology. 91
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are associated with a variety of malignancies. Coevolution of gammaherpesviruses with their hosts has resulted in an intricate relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b27dd148314b28bd8b879f3c474fb66
https://doi.org/10.1128/jvi.01444-16
https://doi.org/10.1128/jvi.01444-16