Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Mitchell P, Levesque"'
Autor:
Rebekka Wegmann, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Ricardo Coelho, Cinzia Esposito, Joanna Ficek-Pascual, Sandra Goetze, Gabriele Gut, Francis Jacob, Andrea Jacobs, Jack Kuipers, Ulrike Lischetti, Julien Mena, Emanuela S. Milani, Michael Prummer, Jacobo Sarabia Del Castillo, Franziska Singer, Sujana Sivapatham, Nora C. Toussaint, Oliver Vilinovszki, Mattheus H. E. Wildschut, Tharshika Thavayogarajah, Disha Malani, The TumorProfiler Consortium, Rudolf Aebersold, Marina Bacac, Niko Beerenwinkel, Christian Beisel, Bernd Bodenmiller, Viola Heinzelmann-Schwarz, Viktor H. Koelzer, Mitchell P. Levesque, Holger Moch, Lucas Pelkmans, Gunnar Rätsch, Markus Tolnay, Andreas Wicki, Bernd Wollscheid, Markus G. Manz, Berend Snijder, Alexandre P. A. Theocharides
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) wit
Externí odkaz:
https://doaj.org/article/d909919fc46044dd87b6ffb2a1e8a194
Autor:
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon-Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan-Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2262-2267 (2024)
Externí odkaz:
https://doaj.org/article/4674eb9ca9f241b4a3996ff03dc79709
Autor:
Yun-Tsan Chang, Pacôme Prompsy, Susanne Kimeswenger, Yi-Chien Tsai, Desislava Ignatova, Olesya Pavlova, Christoph Iselin, Lars E. French, Mitchell P. Levesque, François Kuonen, Malgorzata Bobrowicz, Patrick M. Brunner, Steve Pascolo, Wolfram Hoetzenecker, Emmanuella Guenova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cancer-associated immune dysfunction is a major challenge for effective therapies. The emergence of antibodies targeting tumor cell-surface antigens led to advancements in the treatment of hematopoietic malignancies, particularly blood cance
Externí odkaz:
https://doaj.org/article/1a3bf0a991644740869501ab71bb08ef
LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Autor:
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-18 (2023)
Abstract Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumor
Externí odkaz:
https://doaj.org/article/1a3e75bad0684eebb8afbad93d505cd9
Autor:
Anastasia Samarkina, Markus Kirolos Youssef, Paola Ostano, Soumitra Ghosh, Min Ma, Beatrice Tassone, Tatiana Proust, Giovanna Chiorino, Mitchell P. Levesque, Sandro Goruppi, Gian Paolo Dotto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Melanoma provides a primary benchmark for targeted drug therapy. Most melanomas with BRAFV600 mutations regress in response to BRAF/MEK inhibitors (BRAFi/MEKi). However, nearly all relapse within the first two years, and there is a connectio
Externí odkaz:
https://doaj.org/article/c3125598e94f431c92edea912b20ab71
Autor:
Ulrike Lischetti, Aizhan Tastanova, Franziska Singer, Linda Grob, Matteo Carrara, Phil F. Cheng, Julia M. Martínez Gómez, Federica Sella, Veronika Haunerdinger, Christian Beisel, Mitchell P. Levesque
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Multi-omics profiling by CITE-seq bridges the RNA-protein gap in single-cell analysis but has been largely applied to liquid biopsies. Applying CITE-seq to clinically relevant solid biopsies to characterize healthy tissue and the tumor micro
Externí odkaz:
https://doaj.org/article/0ca7c687976342d7944098a427595259
Autor:
Markus Haake, Beatrice Haack, Tina Schäfer, Patrick N. Harter, Greta Mattavelli, Patrick Eiring, Neha Vashist, Florian Wedekink, Sabrina Genssler, Birgitt Fischer, Julia Dahlhoff, Fatemeh Mokhtari, Anastasia Kuzkina, Marij J. P. Welters, Tamara M. Benz, Lena Sorger, Vincent Thiemann, Giovanni Almanzar, Martina Selle, Klara Thein, Jacob Späth, Maria Cecilia Gonzalez, Carmen Reitinger, Andrea Ipsen-Escobedo, Kilian Wistuba-Hamprecht, Kristin Eichler, Katharina Filipski, Pia S. Zeiner, Rudi Beschorner, Renske Goedemans, Falk Hagen Gogolla, Hubert Hackl, Rogier W. Rooswinkel, Alexander Thiem, Paula Romer Roche, Hemant Joshi, Dirk Pühringer, Achim Wöckel, Joachim E. Diessner, Manfred Rüdiger, Eugen Leo, Phil F. Cheng, Mitchell P. Levesque, Matthias Goebeler, Markus Sauer, Falk Nimmerjahn, Christine Schuberth-Wagner, Stefanie von Felten, Michel Mittelbronn, Matthias Mehling, Andreas Beilhack, Sjoerd H. van der Burg, Angela Riedel, Benjamin Weide, Reinhard Dummer, Jörg Wischhusen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoin
Externí odkaz:
https://doaj.org/article/5207814fce1e426b9e431dafa4d554e4
Autor:
Alessandra Curioni-Fontecedro, Mitchell P Levesque, Roland Bruderer, Marco Tognetti, Lukas Reiter, Luca Raess, Yuehan Feng, Evelyn Ruth Lattmann, Julia Martinez Gomez, Valérie Lapaire, Stefanie Hiltbrunner, Lars M Steinmetz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/21970d288ce6425895e3028d91e583ab
Autor:
Austeja Amweg, Marina Tusup, Phil Cheng, Ernesto Picardi, Reinhard Dummer, Mitchell P Levesque, Lars E French, Emmanuella Guenova, Severin Läuchli, Thomas Kundig, Mark Mellett, Steve Pascolo
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 996-1006 (2022)
RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of vario
Externí odkaz:
https://doaj.org/article/d73ba5df73fb42d888ad2fe4592ab9ac
Autor:
Gaetana Restivo, Aizhan Tastanova, Zsolt Balázs, Federica Panebianco, Maren Diepenbruck, Caner Ercan, Bodgan-T. Preca, Jürg Hafner, Walter P. Weber, Christian Kurzeder, Marcus Vetter, Simone Münst Soysal, Christian Beisel, Mohamed Bentires-Alj, Salvatore Piscuoglio, Michael Krauthammer, Mitchell P. Levesque
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Fresh vs. slow-frozen tissues from various malignancies are compared for the establishment of 2D, 3D and ex vivo cultures, as well as for scRNAseq analysis, and found to be comparable and suitable for cancer research.
Externí odkaz:
https://doaj.org/article/87d96e9a64c244768ec47752d441b0e3