Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mitchell Mutz"'
Autor:
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm
Externí odkaz:
https://doaj.org/article/4b8d65315776423982c1bea6612cead9
Autor:
Arielle Butts, Jennifer A Martin, Louis DiDone, Erin K Bradley, Mitchell Mutz, Damian J Krysan
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125927 (2015)
Cryptococcosis is one of the most important invasive fungal infections and is a significant contributor to the mortality associated with HIV/AIDS. As part of our program to repurpose molecules related to the selective estrogen receptor modulator (SER
Externí odkaz:
https://doaj.org/article/d788779a16c84687bcf4f7424a3d50c4
Autor:
Mehdi Michel Djamel Numa, Molly K. Moloney, Nambu Mitchell David, Robert R. Webb, Michael Trzoss, Mili Kapoor, Jonathan A. Covel, Quinlyn A. Soltow, Mitchell Mutz, Xiaoming Li, Peter J. Webb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2465-2471
A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a calcineurin based inhibitor of pathogenic fungi, analogs of FK506 were synthesized that were able to permeate mammalian but not fungal cells. Antagonists i
Autor:
Sophie M. C. Gobeil, Leonard D. Spicer, David A. Fox, Jackie J. Lin, Maria Ciofani, William J. Steinbach, Michael J. Hoy, Praveen R. Juvvadi, Ronald A. Venters, Blake C. Barrington, Zanetta Chang, Maria A. Schumacher, Anna F. Averette, Joseph Heitman, Michael Trzoss, Mitchell Mutz, Ying-Lien Chen, Joshua D. Wheaton, Xiaoming Li, Soo Chan Lee, Benjamin G. Bobay, D. Christopher Cole
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subu
Autor:
Terry Roemer, Mitchell Mutz
Publikováno v:
Future medicinal chemistry. 8(12)
Autor:
Richard G. Stearns, Siobhan Pickett, Joe Olechno, Jean Shieh, Maria Sonntag, Richard N. Ellson, David L. Harris, Mitchell Mutz
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 13:97-102
The utility of acoustic droplet ejection (ADE), originally used to transfer dimethyl sulfoxide (DMSO) solutions, is expanded beyond the transfer of DMSO to a wide variety of aqueous solutions common to biochemical experiments and assays. Aqueous-base
Autor:
Mitchell Mutz, Arielle Butts, Jennifer A. Martin, Erin K. Bradley, Damian J. Krysan, Louis DiDone
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125927 (2015)
PLoS ONE
PLoS ONE
Cryptococcosis is one of the most important invasive fungal infections and is a significant contributor to the mortality associated with HIV/AIDS. As part of our program to repurpose molecules related to the selective estrogen receptor modulator (SER
Autor:
Mitchell Mutz, David L. Harris
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 11:233-239
Acoustic energy can precisely and accurately eject a droplet of liquid from a reservoir, enabling delivery of picoliter and nanoliter volumes (Ellson, R.; Mutz, M.; Browning, B.; Lee, L.; Miller, M.; Papen, R. Transfer of low nanoliter volumes betwee
Autor:
Richard N. Ellson, Brent Browning, Jean Shieh, Michael Travis, Richard G. Stearns, Shehrzad A. Qureshi, Mitchell Mutz, Joseph D. Olechno
Publikováno v:
ASSAY and Drug Development Technologies. 3:425-437
Acoustic auditing is a non-destructive, non-invasive technique to monitor the composition and volume of fluids in open or sealed microplates and storage tubes. When acoustic energy encounters an interface between two materials, some of the energy pas
Autor:
Richard Ellson, Mitchell Mutz, Brent Browning, Lawrence Lee, Michael F. Miller, Roeland Papen
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 8:29-34
Acoustic droplet ejection (ADE) gently and precisely aliquots nanoliter and picoliter liquid volumes without any physical contact with the solution being transferred. The technology is very automation-friendly, as it is compatible with conventional m