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pro vyhledávání: '"Mitchell Melikhov-Sosin"'
Autor:
Emily E Nuss, Jessica A. George, Adam A. Goldenberg, Corinne Y. Ostock, David Lindenbach, Christopher Bishop, Mitchell Melikhov-Sosin, Melissa M. Conti
Publikováno v:
The Journal of Neuroscience. 36:9873-9887
Long-term treatment of Parkinson's disease withl-DOPA almost always leads to the development of involuntary movements termedl-DOPA-induced dyskinesia. Whereas hyperdopaminergic signaling in the basal ganglia is thought to cause dyskinesia, alteration
Autor:
Melissa M. Conti, Christopher Bishop, Joy Hallmark, David F. Werner, David Lindenbach, Samantha M. Meadows, Mitchell Melikhov-Sosin
Publikováno v:
Neuropharmacology. 110
l-DOPA is the standard treatment for Parkinson's disease (PD), but chronic treatment typically leads to abnormal involuntary movement or dyskinesia (LID) development. Although poorly understood, dyskinetic mechanisms involve a complex interaction bet