Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Mitchell Kronenberg"'
Autor:
Jie Wang, Indra Adrianto, Kalpana Subedi, Tingting Liu, Xiaojun Wu, Qijun Yi, Ian Loveless, Congcong Yin, Indrani Datta, Derek B. Sant’Angelo, Mitchell Kronenberg, Li Zhou, Qing-Sheng Mi
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-20 (2023)
Abstract Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus. However, underlying molecular programs that guide iNKT subset differentiation rema
Externí odkaz:
https://doaj.org/article/a8b94dfc61f84bf081361ad310518709
Autor:
Tamara Pérez-Jeldres, Fabien Magne, Gabriel Ascui, Danilo Alvares, Matias Orellana, Manuel Alvarez-Lobos, Cristian Hernandez-Rocha, Lorena Azocar, Nataly Aguilar, Alberto Espino, Ricardo Estela, Sergio Escobar, Alejandra Zazueta, Pablo Baez, Verónica Silva, Andres De La Vega, Elizabeth Arriagada, Carolina Pavez-Ovalle, Alejandro Díaz-Asencio, Dante Travisany, Juan Francisco Miquel, Eduardo J. Villablanca, Mitchell Kronenberg, María Leonor Bustamante
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Background and aimsLatin American populations remain underrepresented in genetic studies of inflammatory bowel diseases (IBDs). Most genetic association studies of IBD rely on Caucasian, African, and Asian individuals. These associations have yet to
Externí odkaz:
https://doaj.org/article/7ffc78ebfeca4fa88dee089835f2fae8
Publikováno v:
Bio-Protocol, Vol 13, Iss 14 (2023)
Intestinal intraepithelial lymphocytes (IEL) are a numerous population of T cells located within the epithelium of the small and large intestines, being more numerous in the small intestine (SI). They surveil this tissue by interacting with epithelia
Externí odkaz:
https://doaj.org/article/65f89b129243477e8c99a8eb8279ce25
Autor:
Martina Dicker, Yingcong Li, Daniel A. Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood. In order to identify new pathways leading to colitis, we sought to identify genes
Externí odkaz:
https://doaj.org/article/0fb78cbc4d2a4be89f916e12a324c07f
Autor:
Mallory Paynich Murray, Isaac Engel, Grégory Seumois, Sara Herrera-De la Mata, Sandy Lucette Rosales, Ashu Sethi, Ashmitaa Logandha Ramamoorthy Premlal, Goo-Young Seo, Jason Greenbaum, Pandurangan Vijayanand, James P. Scott-Browne, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Invariant natural killer T cells are known to be composed of a number of phenotypic and functionally distinct populations. Here the authors use transcriptomic and epigenomic analysis to further characterize the peripheral iNKT compartment before and
Externí odkaz:
https://doaj.org/article/8fd3eb5a36ea4cf5a286dfc60609479d
Autor:
Caroline Stienne, Richard Virgen-Slane, Lisa Elmén, Marisol Veny, Sarah Huang, Jennifer Nguyen, Elizabeth Chappell, Mary Olivia Balmert, Jr-Wen Shui, Michelle A. Hurchla, Mitchell Kronenberg, Scott N. Peterson, Kenneth M. Murphy, Carl F. Ware, John R. Šedý
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110553- (2022)
Summary: The Btla inhibitory receptor limits innate and adaptive immune responses, both preventing the development of autoimmune disease and restraining anti-viral and anti-tumor responses. It remains unclear how the functions of Btla in diverse lymp
Externí odkaz:
https://doaj.org/article/1478349ce0de43279023cb936638d0d8
Autor:
Shilpi Chandra, James Gray, William B. Kiosses, Archana Khurana, Kaori Hitomi, Catherine M. Crosby, Ashu Chawla, Zheng Fu, Meng Zhao, Natacha Veerapen, Stewart K. Richardson, Steven A. Porcelli, Gurdyal Besra, Amy R. Howell, Sonia Sharma, Bjoern Peters, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activatio
Externí odkaz:
https://doaj.org/article/4dce5c3c771f4a1abdb502245e1a6bb5
Autor:
Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to h
Externí odkaz:
https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1
Autor:
Dalia E. Gaddis, Lindsey E. Padgett, Runpei Wu, Chantel McSkimming, Veronica Romines, Angela M. Taylor, Coleen A. McNamara, Mitchell Kronenberg, Shane Crotty, Michael J. Thomas, Mary G. Sorci-Thomas, Catherine C. Hedrick
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here Gaddis et al. show that Apolipoprotein AI prevents the conversion of Treg cells into pro-atherogenic T follicular helper cells, and thus regulates the i
Externí odkaz:
https://doaj.org/article/8075bffece434699b9ec64bb663d89a5
Autor:
Riccardo Sibilano, Nicolas Gaudenzio, Marianne K. DeGorter, Laurent L. Reber, Joseph D. Hernandez, Philipp M. Starkl, Oliwia W. Zurek, Mindy Tsai, Sonja Zahner, Stephen B. Montgomery, Axel Roers, Mitchell Kronenberg, Mang Yu, Stephen J. Galli
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features o
Externí odkaz:
https://doaj.org/article/9b661fd658a64195915d136587d50be7