Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Mitchell J. Weiss"'
Autor:
Maria Angeles Lillo Osuna, Lei Han, Jon P. Connelly, Shondra Miller-Preutt, Mitchell J. Weiss, Marcin W. Wlodarski, Senthil Velan Bhoopalan
Publikováno v:
Stem Cell Research, Vol 79, Iss , Pp 103479- (2024)
Diamond-Blackfan anemia syndrome (DBAS) is an inherited bone marrow failure disorder that typically presents in infancy as hypoplastic anemia and developmental abnormalities in approximately 50% of cases. DBAS is caused by haploinsufficiency in one o
Externí odkaz:
https://doaj.org/article/f21789a5250943979693ee10e4025149
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Autor:
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page, Aditi Islam, Zhe Yin Tan, Leon J. DeLalio, Steven Brooks, Poonam Sharma, Kwangseok Hong, Wenhao Xu, Alessandra Simão Padilha, Claire A. Ruddiman, Angela K. Best, Edgar Macal, Daniel B. Kim-Shapiro, George Christ, Zhen Yan, Miriam M. Cortese-Krott, Karina Ricart, Rakesh Patel, Timothy P. Bender, Swapnil K. Sonkusare, Mitchell J. Weiss, Hans Ackerman, Linda Columbus, Brant E. Isakson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
Externí odkaz:
https://doaj.org/article/b9f465340f0741ff838bff1e07d81c95
Autor:
Senthil Velan Bhoopalan, Jonathan S. Yen, Thiyagaraj Mayuranathan, Kalin D. Mayberry, Yu Yao, Maria Angeles Lillo Osuna, Yoonjeong Jang, Janaka S.S. Liyanage, Lionel Blanc, Steven R. Ellis, Marcin W. Wlodarski, Mitchell J. Weiss
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Diamond-Blackfan anemia (DBA) is a genetic blood disease caused by heterozygous loss-of-function mutations in ribosomal protein (RP) genes, most commonly RPS19. The signature feature of DBA is hypoplastic anemia occurring in infants, although some ol
Externí odkaz:
https://doaj.org/article/954998aac9b04c778272299720472298
Autor:
Kaitly J. Woodard, Phillip A. Doerfler, Kalin D. Mayberry, Akshay Sharma, Rachel Levine, Jonathan Yen, Virginia Valentine, Lance E. Palmer, Marc Valentine, Mitchell J. Weiss
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
We characterized the human β-like globin transgenes in two mouse models of sickle cell disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal hemoglobin (HbF; α2γ2). Berkeley SCD mice contain four to 22 randomly arranged
Externí odkaz:
https://doaj.org/article/c7a2b29fe3814d94a95e8c2dce8aa30e
Autor:
Jean-Yves Métais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, Stephanie C. Fowler, Matthew M. Hsieh, Varun Katta, Sagar Keriwala, Cicera R. Lazzarotto, Kevin Luk, Michael D. Neel, S. Scott Perry, Samuel T. Peters, Shaina N. Porter, Byoung Y. Ryu, Akshay Sharma, Devlin Shea, John F. Tisdale, Naoya Uchida, Scot A. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, Shondra Pruett-Miller, Shengdar Q. Tsai, Mitchell J. Weiss
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3379-3392 (2019)
Abstract: Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9–mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strate
Externí odkaz:
https://doaj.org/article/d8bdc8c4db524cf3ab90d0385b570174
Autor:
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 159 (2022)
Interest in the structure, function, and evolutionary relations of circulating and intracellular globins dates back more than 60 years to the first determination of the three-dimensional structure of these proteins. Non-erythrocytic globins have been
Externí odkaz:
https://doaj.org/article/7342d090c6d2456abfab3e5b28021b3b
Autor:
Dong Ha Bhang, Bang-Jin Kim, Byung Gak Kim, Keri Schadler, Kwan-Hyuck Baek, Yong Hee Kim, Wayland Hsiao, Bi-Sen Ding, Shahin Rafii, Mitchell J. Weiss, Stella T. Chou, Thomas F. Kolon, Jill P. Ginsberg, Buom-Yong Ryu, Sandra Ryeom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Self-renewal of spermatogonial stem cells (SSC) is necessary for spermatogenesis and male fertility. Here the authors identify testicular endothelial cells (TECs) as a source of 5 key growth factors for self-renewal and expansion of human and mouse S
Externí odkaz:
https://doaj.org/article/c701091a3ecf450096905ad9df679dde
Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL
Autor:
Alyssa L. Gagne, Jean Ann Maguire, Shilpa Gandre-Babbe, Stella T. Chou, Sarah K. Tasian, Mignon L. Loh, Mitchell J. Weiss, Paul Gadue, Deborah L. French
Publikováno v:
Stem Cell Research, Vol 31, Iss , Pp 157-160 (2018)
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disorder of early childhood characterized by expansion of clonal myelomonocytic cells and hyperactive Ras/MAPK signaling. The disorder is caused by somatic and/or germline mutations
Externí odkaz:
https://doaj.org/article/e092f7cfa7fc439c96d9706ba56ff9a5
Autor:
Hayley A. Hanby, Jialing Bao, Ji-Yoon Noh, Danuta Jarocha, Mortimer Poncz, Mitchell J. Weiss, Michael S. Marks
Publikováno v:
Blood Advances, Vol 1, Iss 19, Pp 1478-1490 (2017)
Abstract: Platelet dense granules (DGs) are storage organelles for calcium ions, small organic molecules such as adenosine 5′-diphosphate and serotonin, and larger polyphosphates that are secreted upon platelet stimulation to enhance platelet activ
Externí odkaz:
https://doaj.org/article/2fd199a845ef48f98c590faacc057683