Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Mitchell J. Picker"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:177-187
Inhibitors of fatty acid amide hydrolase (FAAH) and anandamide (AEA) uptake, which limit the degradation of endogenous cannabinoids, have received interest as potential therapeutics for pain. There is also evidence that endogenous cannabinoids mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef7c8630ad5e0a164cdc0993b19fad2
https://doi.org/10.1124/jpet.112.191478
https://doi.org/10.1124/jpet.112.191478
Publikováno v:
Behavioural Pharmacology. 22:785-793
The present study examined the effects of the mGluR1 antagonist JNJ16259685 (JNJ) and the mGluR5 antagonist 2-methyl-6-phenylethynylpyridine (MPEP) alone and in combination with morphine in two acute pain models (hotplate, warm water tail-withdrawal)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a36a97d307feea7b12239f004463be7
https://doi.org/10.1097/fbp.0b013e32834d13a2
https://doi.org/10.1097/fbp.0b013e32834d13a2
Publikováno v:
Neuroscience. 150:14-21
Rationale Manipulation of glucocorticoid receptor signaling has been shown to alter the acquisition and expression of ethanol-induced locomotor sensitization in mice. It is unknown if other components of the hypothalamic–pituitary–adrenal (HPA)-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ea577900d411acf719de265a495462
https://doi.org/10.1016/j.neuroscience.2007.08.027
https://doi.org/10.1016/j.neuroscience.2007.08.027
Autor:
Mitchell J. Picker, Dennis R. Sparta, Todd E. Thiele, Jon R. Fee, George R. Breese, Darin J. Knapp
Publikováno v:
Neuroscience. 140:21-31
Mutant mice lacking the RIIbeta subunit of protein kinase A (regulatory subunit II beta(-/-)) show increased ethanol preference. Recent evidence suggests a relationship between heightened ethanol preference and susceptibility to ethanol-induced locom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44c476d79b603b914632e17f3c15131
https://doi.org/10.1016/j.neuroscience.2006.02.002
https://doi.org/10.1016/j.neuroscience.2006.02.002
Publikováno v:
The Journal of Pain. 6:372-383
Evidence suggests that gonadal hormones can modulate sensitivity to nociceptive stimuli and opioid antinociception. However, cross-study comparisons addressing the nature of this modulation have been complicated by a number of methodologic factors, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9cf288ef694e273c4bb166133d6e2c
https://doi.org/10.1016/j.jpain.2005.01.354
https://doi.org/10.1016/j.jpain.2005.01.354
Publikováno v:
Pain. 106:381-391
Sex differences in opioid antinociception have been reported in rodents and monkeys, with opioids being more potent in males than females. In the present study, the influence of rat strain on sex differences in opioid antinociception was examined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7368a8bdbeb7e0cb6cd651cdd2e89e3e
https://doi.org/10.1016/j.pain.2003.08.008
https://doi.org/10.1016/j.pain.2003.08.008
Publikováno v:
Journal of Investigative Dermatology. 121:1053-1059
Previous research has demonstrated that, in male rats, the magnitude of contact hypersensitivity (CHS) can be enhanced by morphine treatment. The present experiments test the hypothesis that the mu-opioids morphine, etorphine, and buprenorphine would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6d0be5139537b8da3322b0ef5b5f11
https://doi.org/10.1046/j.1523-1747.2003.12569.x
https://doi.org/10.1046/j.1523-1747.2003.12569.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:1061-1070
The use of irreversible antagonists to assess opioid efficacy has proven fruitful for classifying opioids on the basis of high or low efficacy, but few studies have provided quantitative estimates of efficacy. The purpose of this study was to use bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a3f40df80ec4575fc00b77d12b6a23
https://doi.org/10.1124/jpet.102.047068
https://doi.org/10.1124/jpet.102.047068
Publikováno v:
Behavioural Pharmacology. 14:77-85
The present study examined the influence of sex on the antinociceptive effects of (-)-pentazocine, morphine and spiradoline in four rat strains, using a warm-water (50, 52 and 55 degrees C) tail-withdrawal procedure. In F344, Lewis, Sprague-Dawley (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a659d941befb3bab796f496f063ade08
https://doi.org/10.1097/00008877-200302000-00008
https://doi.org/10.1097/00008877-200302000-00008
Autor:
Jose Manuel Lerma-Cabrera, Francisca Carvajal, Todd E. Thiele, Inmaculada Cubero, Mitchell J. Picker, Montserrat Navarro
Publikováno v:
Alcoholism, clinical and experimental research. 39(8)
Background The nonselective opioid receptor antagonist, naltrexone (NAL), reduces alcohol (ethanol [EtOH]) consumption in animals and humans and is an approved medication for treating alcohol abuse disorders. Proopiomelanocortin (POMC)-derived melano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140e1df981cfec5dd749a7840e118406
https://pubmed.ncbi.nlm.nih.gov/26108334
https://pubmed.ncbi.nlm.nih.gov/26108334